Diabetes Insipidus

Question 1

Nephrogenic Diabetes Insipidus

Answer 1

kidney ADH receptors don’t work/unresponsive

Question 2

Stimulation of ADH

Answer 2

Increased ECF osmolality stimulates osmoreceptors in the hypothalamus
Hypotension
Volume contraction leding to increased ECF osmolality

Question 3

Actions of ADH/Vasopressin

Answer 3

Stimulates reabsorption of water in distal tubule and collecting ducts

Leads to increased water in ECF, deceased ECF osmolality

Question 4

Use of ADH/Vasopressin

Answer 4

IM/IV over an hour in LRS or 5% dextrose for dx of DI

Question 5

Tx of CDI?

Answer 5

Desmopressin

Question 6

What is Desmopressin and how does it work?
Vasocontrictor activity?
How is it given?

Answer 6

synthetic ADH analog that is more potent and has a longer half life than natural ADH
Minimal vasoconstricotr action (more selective on V2 than V1)
Given parenterally or nose drops in conjuctival sac.

Question 7

Drug of choice to tx Nephrogenic diabetes insipidus

Answer 7

Thiazide diuretic

Question 8

Central Diabetes Insipidus

Answer 8

caused by ADH deficiency