Developmental disruptions Flashcards
What are 4 types of chromosome issues that disrupt development?
Aneuploidies, deletions, insertions or pleiotropy
What are the two types of pleiotropy?
Mosaic: one gene that is expressed in two tissues
Relational: one gene only affects one tissue, but messing with that causes disruptions in another tissue
What are teratogens?
Chemicals that cause developmental disruptions
Are all tissues equally susceptible to teratogens at all times?
No, some tissues, namely the central nervous system are more sensitive than others, and some are just more susceptible at certain times then become resistant later on
What effects on the developing embryo did Thalidomide have?
Absence of limbs or reduced limbs
How did Frances Kelsey keep thalidomide from being approved in the US?
She was supposed to review thalidomide for use in the US, so dug into the reports and starting finding evidence that it was a teratogen. She resisted approving it long enough to let the evidence pile up so it was never approved
What is isoretinoin?
A very good treatment for cystic acne, but a very potent teratogen
