Development of the Reproductive System and Pituitary Gland Flashcards
Functionally the urogenital system can be divided into what two entirely different systems?
The urinary and the genital system
The urogenital system is derived from what embryonic tissue?
Intermediate mesoderm
What is the urogenital ridge?
This is intermediate mesoderm that bulges into the intraembryonic coelmic cavity
The urogenital ridge differentiates into what two things?
Nephrogenic cord/ridge and genital ridge
Primordial germ cells originate from what?
Endoderm of the yolk sac
What happens if the primordial germ cells do not migrate to or reach the genital ridge?
The gonads do not develop
How are the primitive sex cords formed?
Epithelium proliferates and epithelial cells penetrate underlying mesenchyme
Primitive sex cords can also be called what?
Gonadal cords
During the indifferent gonad phase, both males and females have what two ductal systems?
Mesonephric (Wolffian) ducts and paramesonephric (Mullarian) ducts
The Y chromosome has what gene that codes for what hormone?
SRY (sex determining region of the Y chromosome) gene that codes for TDF (testes determining factor) hormone
Under influence of TDF, primitive sex cords continue to proliferate and penetrate into the medulla and form what?
The testes (medullary cords)
Towards the hilum the testes cords will break up giving rise to what?
The tubules of the Rete Testis
What is the tunica albuginea?
Fibrous connective tissue that separates the testes cords from surface epithelium
The testes cords are composed of what two things?
Primitive germ cells and sustentacular cells (sertoli cells)
What do the sustentacular (sertoli) cells secrete?
AMH, antimullerian hormone
What does AMH cause?
The degradation of paramesonephric (mullarian) duct
What are interstitial (Leydig) cells?
These are a cell population found between the testis cords
What are interstitial (Leydig) cells derived from?
Mesenchyme from the genital ridge
What do interstitial (Leydig) cells secrete?
Testosterone
The testes cords remain solid until puberty forming what?
Seminiferous tubules
The ductuli efferentes connects what two things?
Rete testis and mesonephric duct
The ductuli efferentes will become what?
Ductus deferens (vas deferens)
The genital ducts are stimulated to develop by what?
Testosterone