Development of the Musculoskeletal System Flashcards

1
Q

What is included in the axial skeletal system?

A

Ribs, vertebra, sternum, and skull

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2
Q

What is included in the appendicular skeleton?

A

Pectoral girdle, pelvic girdle, and limb bones

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3
Q

What are the two divisions of mesoderm that the skeletal system is derived from?

A

Paraxial mesoderm (somites), and lateral plate somatic mesoderm

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4
Q

Paraxial mesoderm differentiates into what?

A

Mesenchyme then vertebral column, ribs, and neurocranium

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5
Q

Lateral plate somatic mesoderm differentiates into what?

A

Mesenchyme then pectoral girdle, pelvic girdle, ribs, and sternum (appendicular skeleton)

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6
Q

Neural crest cells differentiates i

A

Mesenchyme then viscerocranium and hyoid bone

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7
Q

What is all of the axial skeleton derived from, except what exception?

A

Sclerotome forms all of the axial skeleton except the sternum and a portion of the skull

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8
Q

The nucleus pulposus is derived from what?

A

The notocord

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9
Q

At the fourth week of development the sclerotome cells do what?

A

Surround the neural tube and notocord

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10
Q

How are each sclerotomes divided?

A

A less dense cranial portion and a dense caudal portion

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11
Q

The dense portion of the sclerotome form what?

A

Annulous fibrosus of IV discs

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12
Q

The dense portion of a sclerotome fuses with what structure to form what?

A

The less dense portion of the sclerotome immediately inferior to form the vertebral body

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13
Q

When does chondrification of the vertebral bodies occur?

A

6th week

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14
Q

When does ossification of vertebral bodies begin?

A

7th week

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15
Q

When do vertebral arch halves fuse?

A

3-5 years

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16
Q

When does the vertebral arch fuse with the body?

A

3-6 years

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17
Q

When is ossification of vertebral bodies complete?

A

About 25 years

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18
Q

The sclerotome differentiates into what that will become the annulous fibrosus?

A

Intersegmental mesenchyme

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19
Q

The sternum starts off as what two things that will fuse cranial to caudal?

A

Sternal bars

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20
Q

What is the neurocranium?

A

Bones that encase the brain

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21
Q

Where is the viscerocranium?

A

Anterolateral facial bones

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22
Q

What parts of the skull are formed by endochondral ossification?

A

Sphenoid, petrous portion of temporal bone, portion of occipital bone

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23
Q

How is the rest of the skull formed that does not develop from endochondral ossification?

A

Intramembranous ossificaiton

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24
Q

Intramembranous ossification forms what kind of bones that surround the brain?

A

Flat bones

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25
Where is the cartilaginous neurocranium?
Base of the skull
26
Where is the membranous neurocranium?
Flat bones that surround the brain
27
The bregma takes place of what in a newborn?
The anterior fontanelle
28
The pterion takes place of what in a newborn?
Anterolateral or sphenoidal fontanelle
29
The lambda takes place of what in a newborn?
Posterior fontanelle
30
What fontanelle in a newborn does not have a special name that takes its place?
Posteriolateral or mastoid fontanelle
31
When does ossification of long bones begin?
7/8th week
32
Skeletal muscle is derived from what?
Paraxial mesoderm
33
Cardiac muscle is derived from what?
Intraembryonic splanchnic mesoderm surrounding developing heart
34
Smooth muscle of the GI tract is derived from what?
Intraembryonic splanchnic mesoderm surrounding gut tube
35
Somites give rise to what?
Axial skeleton (most), Associated musculature, Overlying dermis of back
36
Somites differentiate into what three initial things?
Sclerotome, myotome, and dermatome
37
What are myoblasts?
Specialized mesoderm cells that fuse together to form skeletal muscle and can actively contract by week seven
38
Progenitor cells for muscle tissues derived from the 1)________ and 2)________ lips of the 3)________
1) Ventrolateral 2) Dorsalmedial 3) Dermomyotome
39
What separates the paraxial mesoderm from lateral plate somatic mesoderm?
Lateral somitic frontier
40
What domain surrounds neural tube and contains only somite-derived cells?
Primaxial domain
41
What domain is the parietal layer of lateral plate mesodem with somite-derived cells
Abaxial domain
42
The ventrolateral lip cells left at the myotome will form what?
Musculature of the back, Shoulder girdle muscles, Intercostal muscles
43
Most Ventrolateral lip (VLL) myoblasts migrate across the frontier into lateral plate somatic mesoderm to form what?
Infrahyoid muscles, Pectoralis major & minor muscles, Abdominal wall muscles, and Limb muscles
44
Each myotome divides into what two things?
Epaxial group (dorsal/posterior)(back) and hypaxial group (ventral/anterior)(includes limbs)
45
Each spinal nerve divides into what two things?
Dorsal primary ramus and ventral primary ramus
46
The sphincter pupillae m. and dilator pupillae m. of the iris are developed from what?
Neuroectoderm
47
Myoepithelial cells of mammary, salivary, & sweat glands are derived from what?
Surface ectoderm
48
Limb buds emerge around the end of what week?
4th
49
Do upper or lower limbs develop first?
Upper followed by lower 1-2 days later
50
What is the distal most end of a developing limb called?
Apical ectodermal ridge (AER)
51
Just proximal to the AER is what zone of the developing limb?
Progress zone
52
Melanocytes of the developing limb come from what?
Neural crest
53
Sensory axons and Schwann cells of the developing limb come from what?
Neural crest
54
Myoblasts of the developing limb come from what?
From myotome of VLL
55
Motor axons of the developing limb come from what?
From neural tube
56
When does limb rotation occur?
Week seven
57
How do the upper limbs developmentally rotate?
Lateral rotation of 90 degrees
58
How do the lower limbs developmentally rotate?
Medial rotation of 90 degrees
59
When is the paddle stage of limb development?
6th week
60
What are digital rays?
Outlines of future digits
61
When will a fetus have fully developed digits?
End of eighth week
62
What is meromelia?
Absence of part of a limb
63
What is amelia?
Absence of an entire limb (absence of AER)
64
What is polydactyly?
Extra digits
65
What is syndactyly?
Two or more fused digits