Dermatology 13 Flashcards
Itchy pain, bronchospasm, localised swelling after morphine(opouds) antibiotics (vancomycin), radiocontrast agents
IgE independent mast cell degranulation
Intracytoppasmic racket shaped granules ( Birbeck granules)
Langerhan cells/ dendritic cell
Antigen presenting cells contain
MHC II AND B7
Hyperkeratosis Parakeratosis Epidermal hyperplasia Elongated rete ridges Munro microabcesses by coalesce of neutrophils foci in stratum corneum and epidermis Auspitz sign positive
Psoriasis
Hyperkeratosis
Acanthosis
Lymphosytic and eosinophilic infiltrate
Atopic dermatitis
Greasy, flat, pigmented squamous epithelial proliferation of immature keratinocytes with keratin filled cyst(horn cyst) well demarcated
Seborrheic keratosis
Associated with gastric adenomacarcinoma
Cigar shaped budding yeast, diamorphic, rose gardener disease . Inoculated into subcutaneous tissue by trauma. . Local papule at site of bite, ulcerate with nodule and erythema spreading along draining lymphatis
Sporothrix schenckii
Ascending lymphangitis
Slow erythematous rash with central scaring at bite site. Flu like symptoms, erythema migrans
Lyme disease
Ixodes deer tick, borrelia burgdorferi
Yaws
Trapenoma pallidium
Painless papule then ulcerate
Mycobacterium merinum
Fish tank / swimming pool papular that ulcerate and scar.
Painless cutaneous papules that evolves over days into Ulcer with black eschar. Painless necrotic
Bacillus anthrax
Cutaneous
Extracellular gram positive rods
Intracellular protozoa with rod shaped kinetoplasts inside macrophages in biopsy.
Enlarging pinkish papules at sire of bite to plaque and ulcerate
Leishmania
Obligate intracelluar protozoa
Mature in macrophages
Transmit by sand flies
Vésicle base shows intranuclear inclusions in keratinocytes and multinucleated giant cells (Tzanck sign) positive.
Vericella zoster
Skin biopsy: acantholysis of keratinocytes and intraepidermal vesicles
Eosinophilic intracytoplsmic inclusions(virus)
Dome shaped umblicated papules
Mulluscum congiosum
Cytoplasmic vacoules in keratinocytes and hyperplasia of epidermis
HPV- SCC of penile, vulva, penile
Neutrophils at tips of dermal papilla
Dermatitis herpetifomis
