7

Question 1

Dense lymphocytic infiltrate of portal triad and granunlomatous destruction of intralobular bile ducts- florid duct lesions

Micronodular regeneration of periportal tissues

Answer 1

Pbc

Question 2

Lobular mononuclear inflammation, hepatocyte balloon degeneration, ground glass hepatocytes. Granular eosinophilic
Cytotoxic t cell mediated hepatocyte undergo apoptosis

Finely granular, diffusely homogeneous pale eosinophilic cytoplasm(ground glass appearance)

Answer 2

Hepatitis B

Question 3

Portal and periportal lymphoplasmacytic infiltration of liver i-e interface hepatitis

Answer 3

AIH

Question 4

Fibrous obliteration of bile ducts , concentric periductal deposition of connective tissue in an onion skin pattern. Beading of intra and extra-hepatic bile ducts on ERCp.
Strongly ass with UC
Cholestatic pattern of liver injury

Answer 4

Primary sclerosing cholangitis

Question 5

Noncaseating granuloma with hepatic fibrosis and multinucleated giant cells formation

Answer 5

Sarcoidosis

Question 6

Nodular lymphoid hyperplasia of intestine

Answer 6

CVID

Question 7

Intranuclear/intracytoplasmic inclusion bodies

Answer 7

CMV ESOPHAGITIS

Question 8

Eosinophilic intranucléar inclusions (cowdry type A) in multinuclear squamous giant cells at ulcer margins-latent virus cause reinfection/symptoms- punched out ulcers volcano like appearance

Answer 8

HSV ESOPHAGITIS

Question 9

Insular (nesting) masses of small round cells with peripheral palisading , granular cytoplasm, small nucleus and salt and pepper chromatin.
Electron microscopy: dense core granule contain bradykinin, serotonin and histamine and hormones (gastrin)

Answer 9

Carcinoid syndrome

Question 10

Connective tissue,smooth muscle and disorganised mucosal cells-polyp?

Answer 10

Hemartamous polyps

Question 11

Small,non mucosal cells that form glands and crypts-poly?

Answer 11

Hyperplastic polyps

Question 12

Stacked circular oesophageal rings, linear furrows, small scattered whitish papules called eosinophilic microabcesses. Food impaction

Answer 12

Eosinophilic esophagitis

Question 13

Fibrous replacement of muscularis in lower oesophagus, esophageal smooth muscle atrophy- decrease LES and dysmotility and peristalsis

Answer 13

Crest/ systemic sclerosis

Question 14

Enlarged but nontender gallbladder-

Answer 14

Courvosier sign-pancreatic adénocarcinoma

Question 15

Large eosinophilic hyperchromatic squamous cell with scant cytoplasm arranged in islands . Nuclear atypia and prominent keratization or keratin pearls.

Ulcerated nodular exophytic anal lesion-HPV 16,18

Answer 15

Squamous cell carcinoma anal

Question 16

Whirls of spindle cells and neovascularisation

Answer 16

Kaposi sarcoma

Question 17

Umblicated flesh colored papules with epidermal hyperplasia eosinophilic intracytoplasmic viral inclusions

Answer 17

Molluscum contagiosum pox virus

Question 18

Diffuse hepatic fibrosis with replacement of normal lobular structure with regenerative parenchymal nodules

Answer 18

Liver cirrhosis

Question 19

Dilatation of sinusoids and perivenular haemorrhage is ass with acute venous outflow obstruction within liver , centrilobular congestion and necrosis
Nutmeg liver(mottled appearance)

Answer 19

Budd chiari syndrome

Question 20

Lymphoid aggregates within the portal tracts and with focal areas of macro-vesicular steatosis

Answer 20

Hepatitis C