Dermatitis Herpetiformis Flashcards
1
Q
What is dermatitis herpetiformis?
A
A chronic, autoimmune, blistering skin disease with very itchy papules and vesicles
2
Q
What is the pathophysiology of dermatitis herpetiformis?
A
- Strong genetic predisposition
- HLA-DQ2, HLA-DQ8
- Main environmental trigger is ingestion of gluten (anti-tTG antibodies form)
3
Q
How does DH present?
A
- Symmetrical, erythematous, itchy papules usually on the elbow, knees and buttocks
- Can present on scalp, face and neck
- Episodes of exacerbation and remission
4
Q
How is DH investigated?
A
- Skin biopsy which shows IgA deposits
- Serology can detect the anti-tTG antibodies
- Screening for coeliac disease is recommended
5
Q
How is DH managed?
A
Lifelong gluten free diet
Dapsone can be given for symptomatic relief
