derm Flashcards
what modulates immune response in atopic dermatitis
langerhans cells, T cells and immune effector cells modulate an inflammatory response to environmental factors
where does atopic dermatitis commonly affect
face/ flexures skin fold regions
what is the waterlow score system used for?
scoring pressure scores
why do pressure sores occur?
constant pressure limits blood flow to the skin leading to tissue damage
complication of psoriasis
anterior uveitis
erythoderma
anti centromere abx positive in what?
scleroderma and vascular injury present
systemic sclerosis
crest syndrome
calcinosis raynouds esophogeal dysmotility sclerodactyly telangiectasis
)___________ is the hardening and tightness of the skin of the fingers and the tips of the fingers appear to curl inwards slightly resulting in the recognisable clawed appearance. This tightening of the skin; can also affect the face, resulting in a ‘beak-shaped’ nose and microstomy (reduced aperture of the mouth).
sclerodactyly
hardening and tightness of skin over fingers / tips of fingers
which antibody cinches diagnosis of lupus?
anti dsDNA
diffues cutanoeus systemic sclerosis
anti rna
anti topoisomerase 1 scl-70
discoid eryhthematous scaly plaque
pt young 20yr old with
generally unwell
arthralgia
chest pain / palpitations
rash on eyelids and spread like a shawl on chest
ddx?
how does it compare
lupus
dermatomyositis
muscle weakness and rash is on knuckles and eyelids - purple in colour
rombergs test positive
heliotrope rash and gottrons papules
and a rash resembling a shawl
what Ix ?
gold standard is muscle biopsy
anti Mi2
antiJo1
CK - plasma muscle enzyme useful
this is dermatomyositosis
inflammation of the fat under the skin?
tender raise red nodules that affect the shin
lymphacytic vasculitis
erythema nodosum
NO cause Drugs: sulphonamides , dapsone Oral cp / pregnancy Sarcoidosis Uc/ crohns Micor: tb, strep, toxoplasmosis
viral/chlamydial infections
inflammation of subcut fat discrete tender, nodules on anterior shins inflammation infection malignancy
erythema nodosum
sarcoidosis, IBD,
TB, Chlamydia, Streptococcal
malignancy: lymphoma/ l;eukaemia
erythema multiforme
how does it look?
Infection: bacterial - mycoplasma pneumoniae
viral :HSV1, VZV
dark centre paler ring raised due to oedema, red ring around periphery
starts on palms and spreads
granulomatosis with polyangitis
smalla and medium vessel vasculitis
how does it present
what blood test markers ?
any systemic signs? where does it impact
URT - sinusitis, epistaxis, saddle nose deformity
LRT- cough, pleuritis
pauci immune glomerulonephritis
p-ANCA
c-ANCA
forthy urine and haematuria
lyme disease cause?
borrelia burgdorferi
ixodes ticks
stages of disease
lyme
1: tick bite, flu, lymphadenopathy
2: days- months
facial nevr and CN palsies, peripheral mononeuritis
CVD: myocarditis, herat block
3:arthritis
acrodermatitis - chronica atrophicans
koplik spots are pathogenomic for?
cx?
measles
grey discoulourations of mucosal membranes
1-3 dys after
acute otitis media
bronchopneumonia
encephalitis
which type of psoriasis is triggered by a streptococcal infection?
guttate psoriasis
stevens johnsons syndrome
medical emergency
URTI symptoms : fever, cold, spre throat
eryhthematous macules - mucous membranes mout, nose, eyes and genitals
drugs whihc cause stevens johnson
lamotrigine
carbemazepine
sulfonamides
beta lactams
allopurinol
nsaids
