Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Year 3 difficult topics > CSI > Flashcards

CSI Flashcards

1
Q

ECOG

fully active able to carry on pre disease performance

A

grade 0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ECOG grade 1

A

restricted in physical activity but ambulatory and able to carry out work in light/ sedentary nature

eg office work/ house work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ambulatory and capable of self care but unable to carry out any work activities
50% of waking hours up and about

A

stage 2 ecog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

stage 3 ecog

A

capable of only limited selfcare, confined to bed/chair more than 50% of waking hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

stage 4 ecog

A

completely disabled cannot carry on any self care

totally confined to bed/chair

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

stage 5ecog

A

dead

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

signs of lung cancer?
examination findings?

what paraneoplastic signs?

A

consolidation, collapse
supraclavicular and axillary lymph node enlargement
pleural effusions: stony dull percussion note and decreased vocal resonance and breath sounds

cushing syndrome and siadh and lambert eaton - small cell
bony mets/ pth related peptide secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

management of SCLC

limited disease

A

cisplatin
etoposide
chest irradiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

extensive disease?

Mx

A

chemo
cisplatin / etoposide
radiotherapy can be aplliative to reduce effects of metastatic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

complications of SCLC?

A

pneumonia

SVC compression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

common metastatses?

A 
brain 
breast
liver
adrenals 
skin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

endocrien complications?

A 
Ectopic ACTH (1%): Cushing’s syndrome; ectopic ADH production (7–10%):
SIADH; hypercalcaemia (bony metastases or PTH-related peptide secretion).
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Investigations?

other

A 
Lung function tests
fbc
u&e
ca2+
alkphos 
lft
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Ix
diagnosis
Staging

A

Diagnosis:
flexible bronchoscopy
Endobronchiol ultrasounded guided transbronchiol needle aspiration

> 3cm so not a central lesion

Sputum cytology, bronchoscopy with brushings and biopsy or percutaneous biopsy, thoracoscopy.
Staging: CT of chest, abdomen, head. Isotope bone scan.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

features of sclc
adh release?
acth?
muscle fatiguebility

A

hyponatraemia
cushings syndrome
acth levels can cause bilateral adrenal hyperplasia > high levels of cortisol > hypokalaemic alkalosis

lambert eaton syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which patients are considered for surgery?

A

t1-2a
N0
M0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

SVC obstruction

A

swelling of face/neck and arms
conjunctival and periorbital oedema

headaches worse in morning
visual disturbances
pulseless JVP distension

mx: radical chemo/radiotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

why does SCLC present with addisons and cushing

A

Arise from endocrine cells (Kulchitsky cells). These are APUD cells, and as a result, these tumours will secrete many poly-peptides mainly ACTH.
They can also cause various presentations such as Addison’s and Cushing’s disease.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what ct scan?

A

contrast enhanced

should also include adrenals and liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

how is limited stage disease determined?

A

t1-4
n0-3
m0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Mx limited disease SCLC

A

4 to 6 cycles of cisplatin-based combination chemotherapy.

Consider substituting carboplatin in people with impaired renal function, poor performance status (WHO 2 or more) or significant comorbidity.

22
Q

when can surgery be considered?

A

SCLC t1-2a
n0
mo

23
Q

t1a

A

tumour measuring 3cm without invasion in the main bronchus

t1a <1cm

24
Q

t1b

t1c

A

t1b 1-2cm

t1c 2-3cm

25
Q

t2

A

3-5cm
bronchus
associated with atelactasis

26
Q

t3?

A

5-7cm
invades chest wall
parietal pericardium
phrenic nerve

27
Q

t4?

A

> 7
associates with another lobe ipsilateral lobe
carina

28
Q

n1

A
  • N1: involvement of ipsilateral intrapulmonary, peribronchial, or hilar lymph nodes
29
Q

n2

A

N2: involvement of ipsilateral mediastinal or subcarinal lymph nodes

30
Q

n3

A
  • N3: involvement of contralateral mediastinal or hilar nodes, or scalene or supraclavicular
    nodes on either side
31
Q

what is a central lesion

A

Central lesions are those located within 3 cm of the proximal bronchial tree, heart, great
vessels, trachea, or other mediastinal structures

32
Q

when do you offer flexible bronchoscopy?

A

central lesion onCT

33
Q

for paratracheal and peri-bronchial intra-parenchymal lung lesions.

A

endobronchial ultrasound-guided transbronchial needle aspiration (EBUSTBNA

34
Q

small round or spindle-shaped cells with scanty cytoplasm, illdefined borders, and finely granular nuclear chromatin (salt-and-pepper
pattern)

A

sclc

35
Q

most common lung cancer?

A

adenocarcinoma
nsclc
Glandular differentiation with mucin-containing elements.
o Most express thyroid transcription factor-1 and napsin A.

36
Q

Characterised by the production of keratin, which may take the form of
squamous pearls or cells with very eosinophilic cytoplasm

A

squamous cell carcinoma
pthrp
hyperparathyroidism but pth is low

37
Q

when do you offer EBUS TBNA?

A

paratracheal

peribronchial intra parenchymal lung lesions

38
Q

central lesions are located within 3cm of where?

A 
bronchial tree
heart
great vessels 
trachea 
mediastinal structures
39
Q

m1a

A

nodules contralateral lobe
pleura
pericardium / effusions in pleural cavity /pericardium

40
Q

m1b

A

single extrathoracic mets

41
Q

m1c

A

multiple extra thoracic mets in 1> organs

42
Q

t4 is invades which structures

A 
ƒ carina
ƒ diaphragm
ƒ great vessels
ƒ heart
ƒ mediastinum
ƒ oesophagus
ƒ recurrent laryngeal nerve
ƒ trachea
ƒ vertebral body
43
Q

thorascore

A 
55<
male
asa physical status 2<
who 3<
dyspnea 3<
diagnosis 
comorbid 3
44
Q

glandular differentiation with mucin containing elements

A

adenocarcinoma

45
Q

expresses thyroid transcription factor 1 and napsin A

A

adenocarcinoma

46
Q

charecteristic protein markers of squamous cell?

A

p63

p40

47
Q

Cells have large nuclei, prominent nucleoli, and a moderate amount of
cytoplasm.

A

large cell carcinoma

48
Q

category 2 dyspnea

A

moderate degree walks slower

49
Q

moderately severe degree

3

A

Moderatly severe degree of dyspnea (has to stop because of breathlessness when walking at own pace on the level)

50
Q

stage 4 dyspnea

A

category 4, Severe degree of dyspnea (stops for breath after walking about 100 yards or after a few minutes on the level)

51
Q

won’t leave the house too breathless when dressing etc

A

stgae 5

Year 3 difficult topics (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions