Degenerative Diseases of the NS

Question 1

In Alzheimer’s Disease, this neuropathological finding correlates best with the severity of the dementia

Answer 1

Neurofibrillary Tangles

Question 2

Atrophy of this region is the most prominent finding visible on MRI in patients with alzheimer’s dementia

Answer 2

Hippocampus

Question 3

Microscopical findings in Alzheimers Disease show widespread loss of nerve cells and is most pronounced in this region

Answer 3

layer II of the entorhinal cortex

page 1089

Question 4

Principal pathologic finding of ALS

Answer 4

loss of nerve cells in the ANTERIOR HORN of the spinal cord and motor nuclei in the BRAINSTEM

Question 5

Difference of Progressive Muscular Atrophy vs ALS in clinical presentation?

Answer 5

Progressive muscular atrophy:
>tendon reflexes are diminished or absent
>signs of corticospinal tract disease cannot be detected