Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmakologie > Cytostatika 2 > Flashcards

Cytostatika 2 Flashcards

1
Q

Alkylantien

A 
Cycloposphamid (+ Mensa)
-phosphamid
Melphalan
Chlorambucil
Busulfan
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Nitrosoharnstoffverbidnungen

A

Carmustin
Lomustin
sehr lipophil -> Hirntumore

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Hydrazinderivate

A

CYP-Aktivierung!
Darcabazid (M.Hodgkin)
Procarbazin (M.Hodgkin, MAO-Hemmer)
Temozolomid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Platinverbindungen

A

Cisplatin
Carboplatin
Erbrechen!
sensorische Neurotoxizität

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Methotrexat

A 
DHFR- Inhibitor (Folsäureantagonisten)
Raltitrexat
Pemetrexed
KM-Suppression (dl)
Rescue-Therapie mit Folinsäure
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

6-Mercaptopurin

A

Aktivierung zu TIMP/TGMP
Hemmung der Purinsynthese + Feedback Hemmung
IA: Allopurinol -> Gicht

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Azathioprin

A

Umwandlung in 6-Mercaptopurin

IA: Allopurinol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pyrimidin-Analoga

A

5-Fluoruracil
Capecitabin (Prodrug-Form)
Tegafur (Prodrug-Form)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

5-FU

A

Hemmung der Thymidilatsynthase
Erhöhte Toxizität durch Folinsäure!
auch bei den Prodrug Formen Capecitabin und Tegafur

KM-Depression (dl)
Mukositis (dl)
Hand-Fuß Syndrom

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Vinca-Allkaloide

A 
Vincristin, -blastin, -desin
Aufbau des Spindelapparates gehemmt
Neurotoxizität (Neuropathie)
Paravasat-Toxizität (i.v.)
keine KM-Depression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Taxane

A 
Paclitaxel
Decetaxel
Cabazitaxel
Abbau des Spindelapparates gehemmt
KM-Depression (dl)
Allergie durch LM-Vermittler
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Etoposid

A

+ Teniposid
Topoisomerase II Hemmer
G2-Phasenhemmung

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Irinotecan

A 
\+ Camptothecin
Topoisomerase I Hemmer
späte Diarrhoe -> Loperamid
Leukopenie (dl)
Cholinerges Syndrom -> Atropin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Doxorubicin

A

Zytostatisches Antibiotikum
Daunorubicin
Kardiotoxizität (dl), maximale Lebensdosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Bleomycin

A

Fe-Bindung

kaum KM-Suppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Asparaginase

A

Spaltet Asparagin in L-Asparaginsäure und Ammoniak

Asparagin fehlt für Wachstum des Tumors

17
Q

Tretionin

A

wirkt auf RARalpha und RXR

18
Q

Arsentrioxid

A

baut kranke Rezeptoren ab

19
Q

IMiDs

A 
Thalidomid
Lenalidomid
Pomalidomid
Bindung an Cereblon -> Abbau von Transkriptionsfaktoren
stark teratogen!
20
Q

Imatinib

A

Hemmung der Tyrosinkinase Bcr-Abl

21
Q

Erlotinib

A

reversibler Tyrosinkinase Hemmer für den EGF-Rezeptor

22
Q

Gefitinib

A

reversibler Tyrosinkinase Hemmer für den EGF-Rezeptor

23
Q

Afatinib

A

irreversibler Tyrosinkinase Hemmer für den EGF-Rezeptor

24
Q

Vemurafenib

A

Serin/Threonin-Kinase-Hemmer
hemmt RAF
nur bei B-RAFV600E Mutation

25
Q

Chronisch Lymphatische Leukämie

A

Ibrutinib
irreversibler Inhibitor der Brutontyrosinkinase
Idelalisib
Inhibitor der PI3-Kinase-delta

26
Q

Multiples Myelom

A

Bortezomib
Cafrfilzomib
Proteasomen-Inhibitoren
hemmt NFkappa B

27
Q

Vismodegib

A

SMO-Inhibitor im Hedgehog-Signalweg

28
Q

Panobinostat

A

Histon-Deacetylase-Inhibitor

29
Q

Venetoclax

A

Bcl2-Inhibitor

30
Q

Olaparib

A

PARP-Inhibitor

Poly-ADP-Ribose-Polymerase

Pharmakologie (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions