CYTOPROTECTIVE/MUCOSAL protective drugs

Question 1

drugs included in CYTOPROTECTIVE/MUCOSAL protective drugs:

Answer 1

1. sucralfate
2. misoprostol
3. colloidal bismuth

Question 2

mechanism of action of sucralfate:

Answer 2

1. aluminum sucrose sulfate

2. bind to injured tissues → forms a protective coating over ulcer beds

Question 3

pharmacokinetics of sucralfate:

Answer 3

1. acc. healing & reduce recurrence

2. administration = MUST be taken → 4x daily

Question 4

indications of sucralfate:

Answer 4

1. duodenal ulcers

2. prevention of stress ulcers

Question 5

side effects of sucralfate:

Answer 5

1. low toxicity

2. drug-interactions (need acidic pH, cannot be combined with PPI, H2- blockers or antacids)

Question 6

mechanism of action of misoprostol:

Answer 6

1. analog of PGE1

2. increase mucosal protection & inhibit acid secretion

Question 7

indications of misoprostol:

Answer 7

reducing risk of ulcers in users of NSAIDs

Question 8

side effects of misoprostol:

Answer 8

1. gastrointestinal upset
2. diarrhea
   (this is a poorly tolerated drug!)

Question 9

CONTRAindication of misoprostol:

Answer 9

PREGNANCY

Question 10

mechanism of action of colloidal bismuth:

Answer 10

1. forms protective coating on ulcerated tissue
2. stimulate mucosal protective mechanism
3. antimicrobial effect
4. sequestration of enterotoxins

Question 11

pharmacokinetics of colloidal bismuth:

Answer 11

used in quadruple therapy to heal peptic ulcers

Question 12

indications of colloidal bismuth:

Answer 12

1. peptic ulcers

2. reduce stool frequency & liquidity in infectious diarrhea

Question 13

side effects of colloidal bismuth:

Answer 13

black stools