Cytokines Flashcards
where does IL-1 come from?
macrophages
where does IL-2 come from?
TH1 cells
where does IL-4 come from?
TH2 cells
which ILs come from TH2 as a main source?
IL-4
IL-6
IL-10
which ILs come from macrophages as a main source?
IL-1
IL-6
IL-8
IL-12
where does IL-12 come from?
dendritic cells
macrophages
B cells
where does IL-3 come from?
activated T helper cells
which interleukins with TNFalpha induce fever?
IL-1
IL-6
which IL stimulates T cells to differentiate into CTLS?
IL-2
what does IL-1 do?
induces fever
produces acute inflammation
what does IL-4 do?
class switching in B cells to IgE & IgG
what does IL-5 do?
activate eonisophils
what does IL-6 do?
induces fever
Th17 cell maturation
stimulates B cell differentiation
what is the function of IL-8?
chemotaxis for neutrophils
what is the function of IL-10?
inhibits Th1 cytokine production
an ‘anti-inflammatory’ cytokine
what is the function of TNFalpha?
chemotaxis for neutrophils
induces fever
where is TNFalpha mainly produced from
macrophages
which cell produces IFNgamma?
TH1 cells
what does IFNgamma do?
activates macrophages
