Culminating Deck: Respiratory/Immune Flashcards

1
Q

What are the three steps of respiration, and what is occurring at each step?

A
  1. pulmonary ventilation, exchange w/ atmosphere and alveoli
  2. external respiration, exchange w/ alveoli and capillaries
  3. internal respiration, exchange w/ capillaries and cells
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2
Q

What are the two zones of the respiratory system, and what is contained by those zones/characterization.

A

Conducting zone = nose to terminal bronchioles. Ciliated epithelium, cartilaginous rings.
Respiratory zone: respiratory bronchioles, alveolar ducts, alveolar sacs, alveoli.

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3
Q

What are the three passages in the nose? The three bony protrusions? What are they lined by?

A

Superior, middle, inferior nasal meatuses.
Super, middle, inferior nasal concha.
Lined by mucosa.

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4
Q

What are the four sinuses on the skull?

A

Frontal, ethmoid, sphenoid, maxillary

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5
Q

Name the 4 types of bronchi and their location.

A

primary = entering lungs
secondary = entering lobes
tertiary = entering bronchopulmonary segments
terminal = entering lung lobules

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6
Q

Define hilum and carina.

A

Hilum = where BVs, airways, nerves, and lymphatics enter and exit lung.
Carina = where trachea splits into primary bronchi.

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7
Q

Describe differences between the right and left lung.

A

Left = superior and inferior lobe, oblique fissure, cardiac notch.
Right = superior, middle, inferior lobe, horizontal and oblique fissures.

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8
Q

What are the three openings on the diaphragm and what do they accomodate?

A

Caval foramen = inferior vena cava
Esophageal hiatus = esophagus, vagus N
Aortic hiatus = desc thoracic aorta, thoracic duct, abdominal aorta

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9
Q

Which arteries, veins and nerves supply the thoracic cage? What innervates the diaphragm?

A

Arteries: Internal thoracic artery (big!), anterior/posterior intercostal arteries
Veins: anterior/posterior intercostal veins
Nerves: Intercostal, subcostal N
The diaphragm is innervated by phrenic N.

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10
Q

Which muscles are responsible for breathing? What is added during labored breathing?

A

external intercostal for inspiration
internal intercostal for expiration
sternocleidomastoid, scalene, pectoralis minor are added.

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11
Q

What are the three pieces of cartilage of the external nose? Which two structures within the nose add moisture?

A

Septal nasal cartilage, lateral nasal cartilage, alar cartilage.
Nasolacrimal ducts and paranasal sinuses add moisture.

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12
Q

What are the three ‘phases’ of the larynx?

A

Nasopharynx, oropharynx, laryngopharynx

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13
Q

What is Boyles law?

A

Pressure of gas in a closed container is inversely proportional to its volume

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14
Q

What is Henry’s law?

A

More gas pressure = more solubility of gas

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15
Q

What is contained in the hilum? List from superior to inferior. Hint: use acronym

A

Acronym: ABV
Pulmonary artery
Primary bronchi
Pulmonary vein

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16
Q

What type of cells exist in the nasal cavity vs. the pharynx?

A

Nasal = pseudostratified ciliated columnar
Pharynx = stratified squamous

17
Q

Differentiate tidal volume, inspiratory reserve volume, and expiratory reserve volume.

A

TV = volume inhaled/exhaled normally
IRV = max volume inhaled normally
ERV = max volume exhaled normally

18
Q

Differentiate between vital capacity, inspiratory capacity, and functional residual capacity.

A

VC = max output after max input
IC = max inhaled after normal exhale
FRC = volume remaining after normal inhale

19
Q

Differentiate between residual volume, total lung capacity, and force exp volume.

A

RV = remaining volume after forceful exhale
TLC = total air lungs can hold
FEV = volume exhaled in 1st second of forceful breath

20
Q

What is Dalton’s law?

A

Each gas in a mixture exerts its own pressure, and the total pressure of gas is the sum of all partial pressure.

21
Q

What are the three factors that influence the movement of O2/CO2 across a respiratory membrane?

A
  1. partial pressure
  2. alveolar ventilation/perfusion into blood
  3. structural characteristics of respiratory membrane
22
Q

As acidity increases, what happens to affinity of hemoglobin?

A

O2’s ability to attach to hemoglobin DECREASES because oxygen wants to enter tissues.

23
Q

What are the three ways that CO2 is transported in the blood?

A
  1. dissolved CO2 in plasma
  2. carbamino compounds
  3. bicarbonate ions
24
Q

Where are baroreceptors located and what do they do?

A

Located in walls of bronchi/bronchioles, prevent alveolar bursting.

25
Where are chemoreceptors located and what do they do?
Located in aortic/carotid bodies, respond to changes in O2, CO2, acidity in blood.
26
What is the complement system (immune)?What are its 3 functions?
The complement system assists the innate immune system through circulating proteins. 1. opsonization (coating) 2. inflammation 3. breaking down pathogen walls
27
What is the central system in the brain for respiration?
Medulla
28
Name the primary vs. secondary lymphoid organs.
Primary = thymus, bone marrow. Secondary = lymph nodes/nodules/follicles, spleen
29
Differentiate between humoral and cell-mediated immunity.
Humoral: Involves B cells and antibodies that attack pathogens in body fluids, before they have entered cells. Cell-mediated: Involves T cells to target infected/cancerous cells.
30
What are some differences between thyroid and cricoid cartilage?
Thyroid: Forms front of larynx (Adam's Apple), open at back Cricoid: Most inferior part of larynx, ring-shaped, stronger
31
Define elastance and compliance. Name one thing that lowers each, and which type of vessel has high.
Elastance = ability for structure to recoil/return back to original shape. Lowered by emphysema. Arteries have high elastance. Compliance = ability for structure to stretch or expand in response to pressure. Lowered by scar tissue. Veins have high compliance.
32
What are the 5 steps of phagocytosis?
1. chemotaxis 2. adherence 3. ingestion 4. digestion 5. killing
33
What does NOT affect the movement of O2 across a membrane?
CO2, H2O
34
Contrast ventilation and perfusion. What is the equation for it?
V = air flow P = blood flow Eq = V/Q
35
What does... 1. high V/high P 2. high V/low P 3. low V/high P indicate?
1. normal healthy lungs 2. blood flow impeded (ex. clot) 3. ventilation impeded (ex. asthma)
36
What do the x and y axis represent for O2-Hb affinity graph?
X = partial pressure of O2 Y = % of O2 bound to hemoglobin
37
What does a left shift of O2-Hb affinity graph associated with? Right?
L = decreased temp, decreased H+ R = (reduced affinity) increased temp, increased H+, increased CO2
38
Why is the H2-O2 curve sigmoidal? What is the significance of the flat top? What is the significance of the steep slope?
Sigmoidal = if one Hb polypeptide chain takes up an O2, the other 3 want to (positive cooperativity) Flat top = Hb polypeptide chains are full Steep slope = Needs to happen fast! Large amount of O2 needs to go to metabolically active tissues.
39
What do antibodies cause?
Acronym: PANIC 1. precipitation (makes insoluble) 2. agglutination 3. neutralization 4. inflammation 5. complement (causes lysis) 1-4 causes opsonization/phagocytosis