CT: Fibers of CT: Collagen, Elastic, Reticular Flashcards
Collagen fiber composition
Collagen protein
T/F: collagen protein the most abundant protein in the body
True
Synthesized inside the cell from 3 polypeptide chains which have large amounts of glycine, proline and hydroxyproline
Procollagen
Essential for the hydroxylation of proline and lysine
Vitamin C
What does vitamin C deficiency lead to?
- ⬇️ collagen formation
- Defective wound healing (scurvy)
Procollagen is secreted and cleaved to form what?
Tropocollagen
What do tropocollagen molecules assemble into?
Collagen fibrils
What do tropocollagen fibrils form?
Collagen fibers
Collagen fibers are secreted into the ECM are what?
Polarized
What produces loose CT?
Fibroblasts
What produces bone?
- Osteoblasts
What produces cartilage?
- Chondroblasts
- Chondrocytes
Type I collagen structures
- Skin
- Bone
- Tendons
- Ligaments
Type I collagen function
Resists tension
Type II collagen location
Cartilage
Type II collagen function
Resists pressure
Type III collagen
Loose CT
Loose CT function
Structural support
Type IV collagen location
Basement membrane
Type IV collagen function
- Support
- Filtration
A heterogenous group of disorders that result from a defect in synthesis or structure of collagen
Ehlers-Danlos syndrome
Deficient production of collagen due to a vitamin C deficiency
Scurvy
Excessive collagen production
Keloids
Fibers that allow the tissue to stretch and recoil
Elastic fibers
Elastic fibers composition
- Elastin
- Microfibrils
Where are elastic fibers found?
- Arterial walls
- Elastic ligaments
- Elastic cartilage
- Skin
- Lungs
What are reticular fibers mostly made up of?
Type III collagen
Where are reticular fibers found?
Basement membran
Where does a majority of reticular fiber production occur?
Fibroblasts
Fills spaces not occupied by cells and fibers
Ground substance
Ground substance function
Medium for diffusion
GAGs commonly located in cartilage and bone
Chondroitin sulfate
GAGs commonly found in skin, lungs, and tendons
Dermatin sulfate
GAGs most commonly found in cartilage and nucleus pulposus
Keratin sulfate
GAGs commonly found in arteries and surfaces of the cells
Heparin sulfate
Consists of a core protein to which the GAGs are bound
Proteoglycans
Proteoglycan configuration
Bottle brush
Glycosylated proteins
Glycoprotein
Glycoproteins that mediates attachment of the cells to ECM
Fibronectin
Glycoproteins that mediates attachment of epithelial cells to basement membrane
Lamanin
Glycoproteins most commonly associated with bone
Osteonectin
Glycoproteins most commonly associated with cartilage
Chondronectin
Forces that cause fluid to leave the capillaries and enter the CT space
Starling forces (hemodynamics)
Increase in tissue fluid beyond normal
Edema
