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Histology > CT: Fibers of CT: Collagen, Elastic, Reticular > Flashcards

CT: Fibers of CT: Collagen, Elastic, Reticular Flashcards

1
Q

Collagen fiber composition

A

Collagen protein

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2
Q

T/F: collagen protein the most abundant protein in the body

A

True

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3
Q

Synthesized inside the cell from 3 polypeptide chains which have large amounts of glycine, proline and hydroxyproline

A

Procollagen

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4
Q

Essential for the hydroxylation of proline and lysine

A

Vitamin C

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5
Q

What does vitamin C deficiency lead to?

A
  • ⬇️ collagen formation
  • Defective wound healing (scurvy)
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6
Q

Procollagen is secreted and cleaved to form what?

A

Tropocollagen

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7
Q

What do tropocollagen molecules assemble into?

A

Collagen fibrils

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8
Q

What do tropocollagen fibrils form?

A

Collagen fibers

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9
Q

Collagen fibers are secreted into the ECM are what?

A

Polarized

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10
Q

What produces loose CT?

A

Fibroblasts

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11
Q

What produces bone?

A
  • Osteoblasts
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12
Q

What produces cartilage?

A
  • Chondroblasts
  • Chondrocytes
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13
Q

Type I collagen structures

A
  • Skin
  • Bone
  • Tendons
  • Ligaments
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14
Q

Type I collagen function

A

Resists tension

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15
Q

Type II collagen location

A

Cartilage

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16
Q

Type II collagen function

A

Resists pressure

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17
Q

Type III collagen

A

Loose CT

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18
Q

Loose CT function

A

Structural support

19
Q

Type IV collagen location

A

Basement membrane

20
Q

Type IV collagen function

A
  • Support
  • Filtration
21
Q

A heterogenous group of disorders that result from a defect in synthesis or structure of collagen

A

Ehlers-Danlos syndrome

22
Q

Deficient production of collagen due to a vitamin C deficiency

A

Scurvy

23
Q

Excessive collagen production

A

Keloids

24
Q

Fibers that allow the tissue to stretch and recoil

A

Elastic fibers

25
Q

Elastic fibers composition

A
  • Elastin
  • Microfibrils
26
Q

Where are elastic fibers found?

A
  • Arterial walls
  • Elastic ligaments
  • Elastic cartilage
  • Skin
  • Lungs
27
Q

What are reticular fibers mostly made up of?

A

Type III collagen

28
Q

Where are reticular fibers found?

A

Basement membran

29
Q

Where does a majority of reticular fiber production occur?

A

Fibroblasts

30
Q

Fills spaces not occupied by cells and fibers

A

Ground substance

31
Q

Ground substance function

A

Medium for diffusion

32
Q

GAGs commonly located in cartilage and bone

A

Chondroitin sulfate

33
Q

GAGs commonly found in skin, lungs, and tendons

A

Dermatin sulfate

34
Q

GAGs most commonly found in cartilage and nucleus pulposus

A

Keratin sulfate

35
Q

GAGs commonly found in arteries and surfaces of the cells

A

Heparin sulfate

36
Q

Consists of a core protein to which the GAGs are bound

A

Proteoglycans

37
Q

Proteoglycan configuration

A

Bottle brush

38
Q

Glycosylated proteins

A

Glycoprotein

39
Q

Glycoproteins that mediates attachment of the cells to ECM

A

Fibronectin

40
Q

Glycoproteins that mediates attachment of epithelial cells to basement membrane

A

Lamanin

41
Q

Glycoproteins most commonly associated with bone

A

Osteonectin

42
Q

Glycoproteins most commonly associated with cartilage

A

Chondronectin

43
Q

Forces that cause fluid to leave the capillaries and enter the CT space

A

Starling forces (hemodynamics)

44
Q

Increase in tissue fluid beyond normal

A

Edema

Histology (17 decks)

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