Cell Bio: Membranous Organells Flashcards
Found in every cell, but the amount may differ depending on the major function of the cell
Membranous organelles
Seen in an electron micrograph as a membrane-lined sac
Rough Endoplasmic Reticulum (RER)
What is the RER’s outer surface covered with?
Ribosomes
What is the RER’s interior region called?
Cisterna
What is the membrane of the RER continuous with?
Outer membrane that surrounds the nucleus
The RER is present in all cells but where are they particularly abundant?
In cells specializing in protein secretion
Proteins synthesized by the RER
- Secretory proteins
- Enzymes of the lysosome
- Proteins that will become part of the membrane proteins of the:
1. ER
2. Golgi apparatus
3. Lysosomes
4. Plasma membranes
Where does post-translational modifications of proteins occur?
Cisternae of the RER
Examples of post-translational modifications of proteins
- Folding
- Association of protein subunits
Where do the vesicles of the newly synthesized proteins move to?
Membrane of the Golgi
What does the golgi do to the newly synthesized protein?
Further modifies
Ribosomes are small particles composed of what?
Ribosomal RNA
Some ribosomes are attached to what?
RER
Ribosomes that aren’t attached to the RER
Free ribosomes
What are free ribosomes responsible for?
Formation of proteins used within the cell (various cellular enzymes)
Irregular network of smooth channels that appear to be tubular
Smooth Endoplasmic Reticulum (SER)
What is SER responsible for?
Synthesis of membrane phospholipids (as well as cholesterol and triglycerides)
SER are particularly prominent in cells that do what?
Synthesize steroid hormones
SER are found in these type of cells that are exposed to certain drugs
Hepatocytes
Enzymes involved in which action is attached to the SER?
Detoxification
What is the SER called in muscle cells?
Sarcoplasmic reticulum
What is the sarcoplasmic reticulum involved in?
Storage of calcium (necessary for the initiation of muscle contraction)
Appear as parallel stack of plate-like membrane compartments
Golgi apparatus
Organelle that appears as parallel stack of plate-like membrane compartments
Golgi apparatus
Golgi function
Processing of proteins that are synthesized on the RER
How do the proteins synthesized on the RER reach the golgi?
Vesicles containing secretory products from the RER travel to the golgi
Where does the addition of carbohydrates to certain AAs (forming glycoproteins) occur?
Golgi
What are the proteins modified by the golgi packaged into?
Vesicles or granules
Where are the proteins modified by the golgi transported?
Out of the cell (via a signal)
What is the plasma membrane constantly doing?
Changing
Some vesicles that leave the golgi complex are loaded with digestive enzymes and become incorporated into what?
Lysosomes
Membrane enclosed vesicles that contain digestive enzymes
Lysosomes
What do lysosomes contain a large number of?
Hydrolases