CSF and hydrocephalus Flashcards

1
Q

where is the majority of CSF produced

A
lateral ventricle (65%)
also produced in third and fourth ventricles
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2
Q

what is the main component that differentiates CSF composition from serum?

A

protein - protein is MUCH higher in serum

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3
Q

what are the four general functions of CSF

A

protection of the brain from pressure and temperature changes
buoyancy - makes brain lighter
metabolic - takes toxins away from brain
endocrine - transports hormones between areas of the brain

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4
Q

what occurs when CSF accumulates within the cerebral ventricles or subarachnoid space

A

enlarged ventricles

increased ICP

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5
Q

what is it called when there is an abnormality inhibiting CSF resorption

A

communicating or non-obstructive hydrocephalus

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6
Q

how does inhibited reabsorption of CSF affect CSF flow

A

flow of CSF is blocked after it exits ventricles

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7
Q

what is the triad of sxs associated with chronic communicating hydrocephalus

A

dementia
apraxic gait
urinary incontinence

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8
Q

what kind of hydrocephalus may be caused by increased viscosity of CSF

A

chronic communicating hydrocephalus

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9
Q

what is the underlying condition of chronic communicating hydrocephalus/normal pressure hydrocephalus?

A

pathologically enlarged ventricles

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10
Q

what is hydrocephalus ex-vacuo

A

communicating hydrocephalus

compensatory enlargement of cerebral ventricles and subarachnoid spaces

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11
Q

what conditions can cause hydrocephalus ex-vacuo

A

schizophrenia
brain atrophy (dementia)
post-traumatic brain injury

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12
Q

is ICP altered in hydrocephalus ex-vacuo

A

no

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13
Q

what causes non-communicating hydrocephalus?

A

accumulation of CSF secondary to a structural obstruction of flow

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14
Q

what kind of hydrocephalus presents with decreased conciousness, difficulty looking up, papilledema, and cognitive or developmental delays

A

aqueductal stenosis

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15
Q

what are three causes of aqueductal stenosis

A

tumor compression
narrow aqueduct
gliosis

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16
Q

where is the most likely place to find a blockage of CSF flow

A

aqueduct

17
Q

what causes a dandy-walker malformation

A

obstruction of outlet of 4th ventricle

cerebellar hypoplasia

18
Q

what kind of hydrocephalus involves complete or partial agenesis of the cerebellar vermis

A

dandy-walker malformation

19
Q

what hallmark is associated with chiari II malformation?

A

lumbosacral meningocele

20
Q

what causes chiari malformation

A

congenital tonsillar herniation secondary to:

  • structural defects to brain and SC
  • genetic mutation
  • lack of vitamins in maternal diet
21
Q

what causes acquired hydrocephalus

A

something blocks CSF flow - brain tumor, cyst, head trauma, subarachnoid hemorrhage, meningitis