Crystal Arthropathy Flashcards
what is gout tophus
a massive accumulation of uric acid-usually foot but can also be in ear or elbow
what causes gout
uric acid is produced form th breakdown of purines
usually its put into the blood and excreted through the kidneys
if too much is made then it makes deposits in the body
leads to hyperuriceamia
what are risk factors of hyperuricemia
men-produce more
alcohol
genetics
kidney problems
overproduction things that lead to gout
malignancy
drugs
errors of metabolism
under excretion things that lead to gout
renal impairment
hypertension
hypothyroidism
alcohol-beer, men , age
what is leach nyan syndrome
HPRT deficiency
how do you investigate gout
aspirate
send to lab
appears like needs
what are the symptoms of gout
red
warm swelling
tophus formation
acute attack after large meal with red meat
what does it appear like under the microscope
negative birefringent needles
how do you manage gout
NSAIDS-indomethacin
steroids
how do you lower uric acid levels
-xanthine oxidase inhibitors-allopurinol
what is pseudohout
common of the knee
caused by calcium phosphate crystals
what invesigtaiton should you do
aspiration
positively rhomboid shaped
how do you treat pseudogout
NSAIDS
steroids
colchicine
what is the presentation of pseudogout
pain and swelling with acute inflammtion
usually the knee
