CORTEXT week 2 Flashcards
What is an arthropathy?
Disease of a joint
What is arthritis?
Inflammation of a joint
What is arthralgia?
Pain in a joint
What are the 2 main categories of arthritis?
Non-inflammatory
Inflammatory
What are the 2 categories of inflammatory arthritis?
Seropositive arthritis
Seronegative inflammatory arthropathy
What are some seropositive arthritis?
Rheumatoid arthritis Lupus Scleroderma Vasculitis Sjogren's
Whats are some seronegative inflammatory arthropathies?
Ankylosing spondylitis
Psoriatic arthritis
Reactive arthritis
IBD arthritis
What is a seropositive condition?
Presence of auto-antibodies in serum
What is anti-CCP antibody associated with?
Rheumatoid arthritis
What is ANA associated with?
SLE Sjogren's Sclerosis MCTD Autoimmune liver disease
What is Anti-dsDNA associated with?
SLE
What is anti SM associated with?
SLE
What is anti-Ro associated with?
SLE
Sjogrens
What is anti-la associated with?
Sjogrens
What is anti-centromere associated with?
Systemic sclerosis (limited)
What is anti-scl-70 associated with?
Systemic sclerosis (diffuse)
What is anti-RNP associated with?
SLE
Mixed connective tissue disease
What is anti-jo-1 associated with?
Myositis
What is Anti-cardiolipin antibody and lupus anti-coagulant associated with?
Anti-phospholipid syndrome
What is ANCA associated with?
Small vessel vasculitis
What is the most common form of arthritis?
Osteoarthritis
What are some causes of secondary Osteoarthritis?
Congenital dislocation of the hip Perthes SUFE Previous intra‐articular fracture Extra‐articular fracture with malunion Osteochondral / hyaline cartilage injury Crystal arthropathy Inflammatory arthritis (can give rise to mixed pattern arthritis) Meniscal tears Genu Varum or Valgum
What is seen on OA x-ray?
Loss of joint space
Osteophytes
Sclerosis
Subchondral cysts
What are the four groups of inflammatory arthropathies?
Seropositive
Seronegative
Infectious
Crystal deposition disorders
What is the main treatment for inflammatory arthopathies?
Analgesia Anti-inflammatory -Steroids and NSAIDs Steroid injections DMARDs
What are the symptoms of inflammatory arthritis?
Joint pain with associated swelling Morning stiffness Improvement in symptoms with exercise Synovitis on examination Raised inflammatory markers (CRP and plasma viscosity) Extra-articular symptoms
What is the most prevelant seropositive inflammatory arthropathy?
Rheumatoid arthritis
Where does RA affect?
Small joints of hands and feet
Knees shoulders and elbows can be affected
Which gender gets RA more?
Women