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MSK lectures > CORTEXT week 2 > Flashcards

CORTEXT week 2 Flashcards

1
Q

What is an arthropathy?

A

Disease of a joint

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2
Q

What is arthritis?

A

Inflammation of a joint

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3
Q

What is arthralgia?

A

Pain in a joint

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4
Q

What are the 2 main categories of arthritis?

A

Non-inflammatory

Inflammatory

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5
Q

What are the 2 categories of inflammatory arthritis?

A

Seropositive arthritis

Seronegative inflammatory arthropathy

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6
Q

What are some seropositive arthritis?

A 
Rheumatoid arthritis
Lupus
Scleroderma
Vasculitis
Sjogren's
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7
Q

Whats are some seronegative inflammatory arthropathies?

A

Ankylosing spondylitis
Psoriatic arthritis
Reactive arthritis
IBD arthritis

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8
Q

What is a seropositive condition?

A

Presence of auto-antibodies in serum

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9
Q

What is anti-CCP antibody associated with?

A

Rheumatoid arthritis

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10
Q

What is ANA associated with?

A 
SLE
Sjogren's
Sclerosis
MCTD
Autoimmune liver disease
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11
Q

What is Anti-dsDNA associated with?

A

SLE

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12
Q

What is anti SM associated with?

A

SLE

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13
Q

What is anti-Ro associated with?

A

SLE

Sjogrens

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14
Q

What is anti-la associated with?

A

Sjogrens

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15
Q

What is anti-centromere associated with?

A

Systemic sclerosis (limited)

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16
Q

What is anti-scl-70 associated with?

A

Systemic sclerosis (diffuse)

17
Q

What is anti-RNP associated with?

A

SLE

Mixed connective tissue disease

18
Q

What is anti-jo-1 associated with?

19
Q

What is Anti-cardiolipin antibody and lupus anti-coagulant associated with?

A

Anti-phospholipid syndrome

20
Q

What is ANCA associated with?

A

Small vessel vasculitis

21
Q

What is the most common form of arthritis?

A

Osteoarthritis

22
Q

What are some causes of secondary Osteoarthritis?

A 
Congenital dislocation of the hip
Perthes
SUFE
Previous intra‐articular fracture
Extra‐articular fracture with malunion
Osteochondral / hyaline cartilage injury
Crystal arthropathy
Inflammatory arthritis (can give rise to mixed pattern arthritis)
Meniscal tears
Genu Varum or Valgum
23
Q

What is seen on OA x-ray?

A

Loss of joint space
Osteophytes
Sclerosis
Subchondral cysts

24
Q

What are the four groups of inflammatory arthropathies?

A

Seropositive
Seronegative
Infectious
Crystal deposition disorders

25
Q

What is the main treatment for inflammatory arthopathies?

A 
Analgesia
Anti-inflammatory
-Steroids and NSAIDs
Steroid injections
DMARDs
26
Q

What are the symptoms of inflammatory arthritis?

A 
Joint pain with associated swelling
Morning stiffness
Improvement in symptoms with exercise
Synovitis on examination
Raised inflammatory markers (CRP and plasma viscosity)
Extra-articular symptoms
27
Q

What is the most prevelant seropositive inflammatory arthropathy?

A

Rheumatoid arthritis

28
Q

Where does RA affect?

A

Small joints of hands and feet

Knees shoulders and elbows can be affected

29
Q

Which gender gets RA more?

MSK lectures (50 decks)

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