COPD Flashcards
1st line antibiotic for COPD exacerbation
amoxicillin
1st line antibiotic for COPD exacerbation if penicillin allergic
Doxycycline
2nd line antibiotic for COPD exacerbation
Doxycycline
is it a restrictive or obstructive disease
restricitve
what would you expect to see in pulmonary function tests
decreased FEV1
decreased FVC
deceased PEFR
what happens to FEV1
decreases
what happens to FVC
decreases
what happens to PEFR
decreases
what drugs are used (5)
LAMA, LABA, ICS, SAMA SABA
give an example of LAMA
tiotropium
give an example of LABA
fomoterol
give an example of ICS
Beclometasone
give an example of SAMA
Ipratropium
give an example of SABA
salbutamol
what is the predicted FEV1 for someone with COPD
> 80%
what is the predicted FEV1 for someone with mild COPD
> 80%
what is the predicted FEV1 for someone with moderate COPD
50-79%
what is the predicted FEV1 for someone with severe COPD
30-49%
what treatment is give during an ACUTE exacerbation COPD
(isoap)
Ipratropium (nebulised) Salbutamol (nebulised) Oxygen Antibiotics prednisalone (oral)
what is the mechanism of action of SABA/LABA
Agonist binds to beta-2-adrenoceptor which initiates chain of reactions that causes ATP to be converted into cAMP leading to relaxation of airway smooth muscle
what is the mechanism of action of ICS
anti-inflammatory affect due to mediating transcription of specific genes to alter mRNA levels and the rate of synthesis if inflammatory and anti-inflammatory proteins
what is the mechanism of action of SAMA
non-selective, anti-cholinergic bronchodilator
what is the mechanism of action of LAMA
M3 selective, anti-cholinergic bronchodilator
