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Resp - mine > COPD > Flashcards

COPD Flashcards

1
Q

1st line antibiotic for COPD exacerbation

A

amoxicillin

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2
Q

1st line antibiotic for COPD exacerbation if penicillin allergic

A

Doxycycline

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3
Q

2nd line antibiotic for COPD exacerbation

A

Doxycycline

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4
Q

is it a restrictive or obstructive disease

A

restricitve

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5
Q

what would you expect to see in pulmonary function tests

A

decreased FEV1
decreased FVC
deceased PEFR

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6
Q

what happens to FEV1

A

decreases

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7
Q

what happens to FVC

A

decreases

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8
Q

what happens to PEFR

A

decreases

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9
Q

what drugs are used (5)

A

LAMA, LABA, ICS, SAMA SABA

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10
Q

give an example of LAMA

A

tiotropium

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11
Q

give an example of LABA

A

fomoterol

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12
Q

give an example of ICS

A

Beclometasone

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13
Q

give an example of SAMA

A

Ipratropium

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14
Q

give an example of SABA

A

salbutamol

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15
Q

what is the predicted FEV1 for someone with COPD

A

> 80%

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16
Q

what is the predicted FEV1 for someone with mild COPD

A

> 80%

17
Q

what is the predicted FEV1 for someone with moderate COPD

A

50-79%

18
Q

what is the predicted FEV1 for someone with severe COPD

A

30-49%

19
Q

what treatment is give during an ACUTE exacerbation COPD

A

(isoap)

Ipratropium (nebulised)
Salbutamol (nebulised)
Oxygen 
Antibiotics 
prednisalone (oral)
20
Q

what is the mechanism of action of SABA/LABA

A

Agonist binds to beta-2-adrenoceptor which initiates chain of reactions that causes ATP to be converted into cAMP leading to relaxation of airway smooth muscle

21
Q

what is the mechanism of action of ICS

A

anti-inflammatory affect due to mediating transcription of specific genes to alter mRNA levels and the rate of synthesis if inflammatory and anti-inflammatory proteins

22
Q

what is the mechanism of action of SAMA

A

non-selective, anti-cholinergic bronchodilator

23
Q

what is the mechanism of action of LAMA

A

M3 selective, anti-cholinergic bronchodilator

Resp - mine (18 decks)

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