Control of Respiration Flashcards

1
Q

Which part of the brain is the main rhythm generator for breathing?

A

Medulla

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2
Q

What are the specialised neurones that generate rhythmical breathing called?

A

Pre-Botzinger complex

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3
Q

What are the steps of neuronal stimulation that causes inspiration?

A
  1. Pre-Botzinger generates rhythm
  2. Excites dorsal neurones
  3. Fire in bursts
  4. Firing of neurone causes contraction of inspiratory muscle.
  5. When firing stops- passive expiration
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4
Q

Which group of neurones generate active expiration using accessory muscles?

A

Ventral neurones–> excite internal intercostals, abdominal muscles

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5
Q

Major muscles of inspiration?

A
  1. Diaphragm

2. External intercostal muscles

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6
Q

Accessory muscles of inspiration?

A
  1. Sternocleidomastoid

2. Scalenus

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7
Q

Muscles used in active expiration?

A
  1. Internal intercostals

2. Abdominal muscle

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8
Q

Which part of the brain terminates inspiration, allowing passive expiration?

A

Pons. Known as the pneuotaxic centre.

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9
Q

What would happen if the pneumotaxic centre was dysfunctional?

A

Apneusis- Prolonged inspiratory gasps with brief expiration

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10
Q

What is the Apneustic area responsible for?

A

Can prolong inspiration by exciting the inspiratory area of the medulla

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11
Q

What types of stimuli are the respiratory brain centres responsive to? (5)

A
  1. Higher brain centres
  2. Stretch receptors
  3. Juxta-pulmonary receptors
  4. Joint receptors
  5. Baroreceptors
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12
Q

What is the Hering Breuer reflex?

A

Pylmonary stretch receptors that inhibit inspiration.

Prevent hyper-inflation of the lungs.

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13
Q

What are the effects of the joint receptors?

A

Impilses from moving limbs that increase breathing.

Increases ventilation in exercise

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14
Q

What other factors can increase ventilation during exercise? (3)

A
  1. Adrenaline
  2. Impulses from cerebral cortex
  3. rise in temperature
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15
Q

What are the steps involved in the cough reflex? (4)

A
  1. Short breath intake
  2. Closure of larynx
  3. Contraction of abdominal muscles
  4. Larynx opens, expulsion of air at high speed
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16
Q

What is the main factor of chemical control of respiration?

A

Blood gas tension, especially C02

17
Q

What are the two types of respiratory chemoreceptors?

A
  1. Central

2. Peripheral

18
Q

Peripheral chemoreceptors detected _ and _ and _ concentration in blood

A

02,C02 and H+

19
Q

Central chemoreceptors detectives _ concentration sonly in _ fluid

A

H+, Cerebrospinal

Cerebrospnal fluid impermeable to H+ and HC03-. But CO2 readily diffuses into it.

20
Q

What is hypercapnia? What is its effect of ventilation ?

A

Abnormally high CO2 concentrations in blood.
Causes increased ventilation
Ventilation very susceptible to small change in PCO2

21
Q

What is hypoxia? Effect on ventilation?

A

Abnormally low levels of 02 in blood.

Increases ventilation

22
Q

What is the effect of high altitudes on PO2?

A

Reduces atmospheric pressure

P02 decreases.

23
Q

How does the body deal with this initially and over time?

A

initally- Hyperventilation and increased CO

Over time

  • RBC’S increase to carry more 02
  • 2,3BPG produced which offloads more 02 to tissues
  • Mitochondria increase
  • Increase in capillaries and branches