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Diseases of Human Systems BDS3 > Connective Tissue Disease > Flashcards

Connective Tissue Disease Flashcards

1
Q

what are the 4 multisystem vasculitis inflammatory diseases

A

systemic lupus erythematosus, systemic sclerosis, sjogrens syndrome, undifferentiated connective tissue disease

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2
Q

what causes damage with connective tissue disease

A

complement activation

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3
Q

what are the 3 types of vasculitic disease

A

large vessel (giant cell arteritis), medium vessel (polyarteritis), small vessel (Wegner’s granulomatosis)

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4
Q

what is the general management of connective tissue disease

A

immune suppression, analgesic NSAIDs, immune modulating treatment, biologic medication, systemic steroids

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5
Q

what are the antibodies in autoimmune diseases

A

ANA, dsDNA, Ro, La, anti-centromere, anti-SCL-70, ANCA

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6
Q

what is discoid lupus

A

tissue changes without the blood antibodies

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7
Q

what are the immune complexes involved in systemic lupus

A

ANA, dsDNA, Ro

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8
Q

what systems are involved in lupus

A

joints, skin, kidney, muscles, blood, CVS, RS and CNS

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9
Q

what age group usually gets systemic lupus

A

females of child bearing age

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10
Q

what feature on the face is common with lupus

A

butterfly zygomatic rash (photosensitivity)

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11
Q

what are the dental aspects of lupus

A

ulcers and GA risk, bleeding tendency, impaired drug metabolism, drug reactions, increased malignancy risk, lichenoid reactions

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12
Q

what is the lupus anticoagulant

A

marker found in the blood of some patients with lupus

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13
Q

what are patients with the lupus anticoagulant termed

A

antiphospholipid antibody syndrome (primary or secondary)

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14
Q

what is antiphospholipid antibody syndrome characterised by

A

recurrent thrombosis

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15
Q

what is sjogrens syndrome

A

inflammatory disease associated with circulating antibodies

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16
Q

what antibodies are present in sjogrens

A

ANA, Ro and La

17
Q

what are the features of sjogrens

A

dry eyes and dry mouth, oral disease caused by xerostomia

18
Q

what is sicca syndrome

A

sjogrens only affecting either mouth of eyes

19
Q

what is primary sjogrens

A

mouth and eyes only

20
Q

what is secondary sjogrens

A

associated with another connective tissue disease

21
Q

what is the diagnostic criteria for sjogrens

A

dry eyes/mouth
histopathology findings
autoantibodies
imaging

22
Q

what are the dental implications of sjogrens

A

oral infection, caries risk, functional loss, denture retention, sialosis, salivary lymphoma

23
Q

what is systemic sclerosis

A

excessive collagen deposition, connective tissue fibrosis, loss of elastic tissue

24
Q

what does the patient with systemic sclerosis present like

A

cannot stretch and bind skin, haemangiomas on face, cannot open mouth wide, struggle swallowing

25
Q

what do you need to consider dentally with systemic sclerosis

A

limited mouth opening so plan treatment in advance

26
Q

what is vasculitis

A

inflammation of blood vessels

27
Q

what does giant cell arteritis present like

A

chewing claudication, occlusion of central retinal artery (blindness)

28
Q

who is affected by polymyalgia rheumatica

A

elderly

29
Q

what does polymyalgia rheumatica present like

A

pain and morning stiffness in muscles, malaise and fatigue

30
Q

who gets kawasaki disease

A

children

31
Q

what does kawasaki disease present like

A

fever and lymphadenopathy, strawberry tongue, cracked tongue

32
Q

what is wegners granulomatosis

A

inflammatory conditions which can lead to destruction of hard and soft tissues of the face and oral cavity

33
Q

what does wegners granulomatosis present like

A

spongy red tissue

34
Q

what is affected with wegners granulomatosis

A

renal and respiratory systems

35
Q

what is fibromyalgia

A

non-specific collection of musculoskeletal symptoms

36
Q

what are the symptoms of fibromyalgia

A

joint pain, muscle pain, functional disorders

37
Q

what are the dental aspects of vasculitides

A

steroid precautions maybe necessary

Diseases of Human Systems BDS3 (16 decks)

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