connective tissue Flashcards
what does CREST stand for in relation to Scleroderma
Calcinosis - calcium deposits in skin
Raynauds - spasm of BV in response to cold/stress
Esophageal dysfunction - acid reflux & decrease in motility
Sclerodactyly - thickening/tightening of skin on fingers and hands
Telangiectasias - dilation of capillaries causing red marks on skin
chronic disease affecting CT and internal organs - overproduction of collagen leading to fibrosis / scarring and inflammation causing the skin and fascia to thicken and harden
Scleroderma
blood vessel disease characterized by inflamm of medium sized arteries - disease prevents adequate oxygenation of tissues and organs causing hypoxia and ischemia
Polyarteritis Nodosa or Vasculitis
idiopathic
what type of hypersensitivity reaction of lupus
Type III
types of Scleroderma
localized
generalized - (limited, diffuse)
inflamm of BV in nose, eyes, ears, sinuses, throat, kidneys, lungs
disease process prevents adequate oxygenation of tissues and organs and causes hypoxia and ischemia
Wegener’s Granulomatosis or Granulomatosis w Polyangiitis
- immune system causes inflamm that damages BV
-autoantibodies against a proteinase causes masses of granulomas to form –> inflamm –> reduced blood flow/O2 to organs
genetic disorder affecting proteins that help elasticity and strength of CT
Marfan’s Syndrome
- defect gene that produces fibrillin (a protein)
- tall stature, thin long extremities, protruding breastbone
fibroblast proliferation w excessive collagen deposition forms ______
adhesions and contractures
when muscles expand but fascia surrounding them doesnt causing pressure =
compartment syndrome
causes of adhesions
sx
infection
trauma
radiation
- chronic inflammation from above starts the normal repair mechanism from tissue disturbance, where fibroblasts lay down excessive CT forming adhesions
causes of Polyarteritis Nodosa
idopathic
- suspect that the immune system involvement causing inflammation of a blood vessel that may cause it to be narrowed causing occlusion or less blood flow
- immune system dysfunction causing necrotizing inflammation of med. sized or muscular arteries
causes of Charcot’s (neurogenic arthritis)
uncontrolled inflammation causes destruction of tissues due to impaired nerve P perception
from HIV, infection, injury, trauma, open sores not healing, spinal cord disease, Parkinson’s, syphilis, alchohol/drug use
