CONNECTIVE TISSUE Flashcards
Holds organs together ``
Connective tissue
Major constituent of Connective tissue is
Extracellular Matrix
Cellular and extracellular component of Connecive tissue
Blood Vessel
ECM
Resident cells
ECM contains
Protein fibers
- Elastic fiber
- Collagen fiver
- reticular fiber
Ground substamce
Residents cells
Mesenchymal cells
Macrophage
Adiposite
Fibroblast
Interstitial fluid in CT gives
metabolic support to cell as the medium for difussion of nutrients and waste products
Connective tissue originates from
Embryonic mesenchyme
Embryonic mesenchyme is tissue developing mainly from the middle layer of embreyo called
Mesoderm
Gives rise to CT
Embryonic mesenchyme
It synthesize and secrets collagen, elastin and substances that makes up ground substance
Fibloblast
substances that makes up ground substance
Gags, proteoglycan and multi adhesive glycoprotein
Serves as medium of difussion of nutrients to all other tissues
Fibloblast
aside from ct itself, this originates locally from mesenchymal cells
Fibloblast
Permanent residents of Connective tissue
Fibloblast
Most common cell in CT, produce and maintain most of tissues extracellular components
Fibloblast
active cells
Fibroblast
quiescent cell
fibrocyte
Fat cells
Adipocytes
found in may organs
Adipocytes
Adipocytes store lipid in a form of neutral fat in the the form of
Triglycerides
Purpose of adiposites
Storage of fat/energy
heat production and insulation
It has phagocytic abiity
Macrophage
Engulf foreign bodies dead cells and etc.
Macrophage
If there is a foreign body, macrophage will engulf it and present it to
Lymphocytes so that lymphocyte will produce antibody and elicit immune response
If a macrophage is present in CT it is called
Histiocytes
Has well developed phagocytic ability and specialize in turnover of protein fibers and removal of dead cells and other materials
Macrophage
Key component of immune response
Macrophage
Antigen presenting cells
Macrophage
Differentiated cells
Mature
undifferentiated cells
immature
Macrophages derived from
bone marrow precursor cells that devide, producing monocytes that circulates in blood. These cells cross epithelial wall of venules to penetrate CT, where they differentiate further, mature and acquire morphologic features of Phagocytic cells.
Mast cells granules provide
Matachromasia. which means they can change the color of basic dyes.
Mast cells contains
Basophilic secretory granules
Basophilic secretory granules serve to
function to loacal inflammatory response, innate immunity and tissue repair.
Basophilic secretory granules
Heparin Histamine Serene proteases Eosinophil and neutrophil chemotactic factors Cytokines Phospholipids
Heparin
anticoagulant
Histamine
provide increased vascular permeability and smooth muscle contraction
Serene proteases
activate various mediators for inflammation
Eosinophil and neutrophil chemotactic factors
attracts leukocytes
Cytokines
direct activities of leukocytes and other cells of immune system
Phospholipids
precursor for conversion of prostaglandins, leukotrienes, and other lipid mediators of the inflammatory response.
Sceretes antibodies/immunoglobulin
Plasma Cells
B-lymphocytes derived
Plasma Cells
Part of humoral immunity-antibodies
Plasma Cells
appearance of plasma cells
clockface/cartwheel
came from blood/napadaan lang
Transcient cells
transcient cells came from blood and migrate to venules to CT by the process called
Diapedesis
called by mast cells through chemotactic factor
leukocytes
hold our body
tensile strength
collagen fiber
stretches
resiliency
elastic fiber
very fine/delicate
structural framework
reticular fiber
makes up population of wondering cells
leukocytes
extremely strong and resilient
collagen fiber
most abundant protein in human body
Collagen fiber
what type of collagen in reticular fiber
Type III collagen
forms reticulum and extremely thin heavily glycocylated fibers
Type III collagen
agyrophilic
reticulat fiber
thinner than type I collagen
Elastic fiber
only seen in blood vessels
Elastic fiber
fills spaces between cells and fibers in CT
Ground substance
Gags also known as
mucopolysaccharides
gags can be
Uronic acis and Hexosamine
unoric acid
Glunoric acid and iduronic acid
hexosamine
glucosamine and galactosamine
composed of core protein which are conveniently attached to various no./combination of gags
proteogylcans
milti adhesive glycoprotein
laminin and fibronectin
for adhesion
laminin
from insoluble fibral netwrok althroughout CT.
fibronectin
TYPES OF CT
Loose CT
Dense CT
areolar tisse
loose CT
regular/irreg
Dense CT
common and generally support epithelial tissue
Loose CT
flexible/not very resistant to stress
Loose CT
more ground substance/cells
Loose CT
has more fiber
Dense CT
adapted to offer stress resistance and protection
Dense CT
has fewer cells
Dense CT
bundle of collagen fibers that appear randomly interwoven
Dense irregular CT
arranged in a defined pattern with fiber
Dense rregular CT
Consist of ground substance with fewer colagen fiber
embreyonic mesenchyme
source of multipotent stemcells
embreyonic mesenchyme
undifferentiated and have large nuclei with prominent nucleus and fine chromatin
embreyonic mesenchyme
embreyonic type of CT
mucoid tissue
Found in umbilical chord and fetal organs
mucoid tissue
abundant ground substance and composed of hyalunoric acid
mucoid tissue
jellylike with sparse collagen fiber and scattered fibroblast
mucoid tissue
mucoid tissue is principal component of
wartons jelly
reticular tissue is produced by
modified fibroblast called reticular cell
reticular tissue seen in
bone marrow, lymph nodes and spleen
