connective tissue Flashcards

1
Q

what is the most abundant and widely distributed tissue in the body?

A

connective tissue . all organs contain connective tissue , including teeth and jaw .

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2
Q

bone , cartilage and blood are all types of?

A

connective tissue

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3
Q

what are the functions of connective tissue ?

A

help in connecting tissue to one another .(ligaments and tendons )

supporting and moving (joints , cartilage , and bone)

cushioning and insulating (adipose tissue )-which is fat tissue

transportation and protection (blood)(has to do with immunity too)

storage (adipose tissue and bones

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4
Q

what I the periodontal ligament ?

A

connective tissue that binds the tooth structure to the surrounding bones.

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5
Q

what are the characteristic features of the connective tissue ?

A

originates from mesoderm germ layer

has more matrix than cells , unlike epithelial tissue (closely packed cells with less intra/extra cellular space ). connective tissue is scattered and not tightly packed

has variety of vascularity :

extracellular matrix :connective tissue is mainly composed of non-living extracellular matrix that separates the cells of the tissue

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6
Q

where does the connective tissue originate from?

A

mesoderm

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7
Q

what does vascularity in tissue depend on ?

A

-the difference in vascularity is dependent on the ground substance and how much space is between cells . the looser they are and the more space available the more vascular it will be

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8
Q

what does variety in vascularity mean when talking about connective tissue ?

A

some are avascular (cartilage)

  • some are poorly vascularized (dense connective tissue)
  • some are highly vascularized (like loose areolar connective tissue)
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9
Q

what important roles does the extra cellular function have in connective tissue ?

A

it plays a role in shape , structure , function of connective tissue .

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10
Q

what basic structural elements of the connective tissue

A

cells

fibers

ground substance (cells and fibers are embedded in ground substance )

some books say that water is also a component

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11
Q

discuss the ground substance .

A

it is like the glue which binds the cells and fibers together . it is the medium through which solutes diffuse between blood capillaries and cells.

the main structure of ground substance is a large structure called glycosoaminglycans (unbranched polysaccharide chains)

the composition and structure of extracellular matrix determines the function and characteristic of connective tissue. for example , if the ground structure is very thick and tough , it can form cartilage or bone . if it is loose and allows presence of vessels it will create areolar or loose connective tissue

the degree of vascularity will also rely completely on the ground substance

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12
Q

what’s another name of glycosoaminglycan (molecule that makes up ground substance)

A

sulfated polysaccharide .

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13
Q

what are the different types of glycosoaminglycan?

A

chondroitin sulfate ( jelly like , exists in cartilage and bone)

dermatin sulfate (exists in skin)

keratin sulfate (present in many areas , bone, cartilage , cornea of eye, etc)

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14
Q

what are other types of ground substance that are NOT glycosoaminglycan?

A

hyaluronic acid , which is non-sulfated polysaccharide .

we have 2 other types when proteins attach with carbohydrates

proteoglycan : if carbohydrate is more than protein

glycoprotein :protein is more than carbohydrate

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15
Q

what are the 3 types of matrix fibers? briefly describe each.

A

there are 3 main different fibers :
1.) collagen fibers (white fibers ): strongest and most abundant fiber in extracellular fibers . it is thick and unbranched . and a little flexible . provides high tensile strength .

2.) reticular fiber : short and fine and highly branched.
acts mainly as cushion and binding

  • both of these fibers are made of collagen but the nature is different
    3. )elastic fiber : very long and thin , unbranched , it is mainly made of elastic protein so it can actually be stretched .
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16
Q

what do the following suffixes mean :-blast

  • cyte
  • clast
A
  • blast : young active cell that secretes matrix
  • cyte:old mature cell , maintaining matrix , doesn’t secrete much
  • clast: resorbs/eat matrix
17
Q

what type of cells are present in connective tissue?

A

fibroblast: most common .secretes both fibers and ground substance of matrix . it is branched , the nucleus is oval , sometimes has nucleoulus . it’s a very active cell. it can change to fibroclast.
microphages: immune cell that are large with scalloped border . it also has a rounded nucleus. it is developed from monocyte which comes from bone marrow . main function is to engulf forge in bodies.

plasma cells: part of immune system .are responsible for anti-body secretion. they are developed from B lymphocyte.has cartwheel shaped nucleus.

immune system is mainly composed of B lymphocyte and T lymphocyte.

mast cells: immune cell that secretes 2 important materials . histamine , which is an anti inflammatory material and heparin which is an anticoagulant.

adipocyte : fat tissue that stores triglycerides . it is very large , it contains large droplet of fats . nucleus is pushed to one side (rind like structure )

connective tissue also contains immune cells.

18
Q

what is the most common cell in connective tissue ?

A

fibroblast

19
Q

what form of connective tissue is avascular ?

A

cartilage

20
Q

what form of connective tissue is poorly vascularized ?

A

dense connective tissue

21
Q

what type of connective tissue is highly vascularized?

A

loose areolar connective tissue

22
Q

what makes up the extra cellular matrix ?

A

ground substance and fibers

23
Q

what are glycosaminoglycans ?

A

large macromolecules (unbranched polysaccharide chains )that make up the ground substance

24
Q

what do fibroblasts secrete ?

A

fibers and ground substance of connective tissue

25
Q

what type of immune cells are present in connective tissue ?

A

macrophages

26
Q

what type of cell is responsible for antibody secretion ?

A

plasma cells

27
Q

what are the name of the cells developed from monocytes ?

A

macrophages

28
Q

what cell has a cartwheel appearance ( nucleus )

A

plasma cells

29
Q

from where do plasma cells develop ?

A

B lymphocytes

30
Q

what are mast cells ?

A

immune cells that secrete 2 important materials

31
Q

what are the 2 important material mast cells secrete?

A

histamine :anti-inflammatory . help dilate small blood vessels in reaction to injury

heparin : antigoagulent

32
Q

what are adipocytes ?

A

fat cells that store try-glycerides . supports , protects and insulates.

33
Q

why do adipocytes appear clear when viewed under microscope ?

A

fat inside the cell dissolves during preparation

34
Q

why are adipocytes described as having a “ ring like structure “?

A

nucleus is peripheral