Congenital infections Flashcards
Active genital herpes at time of delivery risk of infection in newborn if;
Primary infection?
Active recurrent infection?
Primary infection: 50%
Active recurrent infection: 5%
Cardiac lesions associated with congenital rubella infection include?
PDA
Pulmonary artery stenosis
Classic triad of congenital toxoplasmosis?
Retinochoroiditis
Cerebral calcifications
Convulsions (hydrocephalus)
Percentage of patients assymptmatic with congenital toxo at birth?
70 - 90%
Long term complications of congenital toxoplasmosis infection? (4)
Deafness
Seizures
Blindness
Microcephaly
Percentage of newborns infected with congenital CMV?
Estimated 1% all livebirths infected with CMV
Percentage of CMV infected infants who are symptomatic?
10%
5% mild disease, 5% cytomegalic inclusion disease
Late findings of CMV (*ie no acute neonatal infection)?
Deafness
Developmental delay
Clinical findings of Congenital CMV infection? (7)
IUGR Microcephaly Jaundice Purpura/Blueberry Muffin rash Hepatosplenomegaly Intra-cerebral calcification (periventricular) Retinitis
Where does CMV remain latent for life following primary infection?
White blood cells
Findings of early congenital syphilis? (within 3/12 of birth)
Hepatosplenomegaly Rash Desquamation Failure to thrive Snuffles, pseudoparalysis Osteochondritis (long bone x-rays)
Findings of late congenital syphilis? (>2yrs age)
CNS/bones + joints/teeth/skin
8th nerve deafness
Skin: interstitial keratitis
Hutchinson’s Teeth: peg-shaped, notched, central incisors
What does congenital Pavovirus B19 cause?
Myelosuppression (typically RBC –> severe anaemia –> hydrops fetalis)
What is blueberry muffin rash technically called and what is it caused by?
Intradermal erythropoeisis
Secondary to extramedullary erythropoeisis due to severe intrauterine anaemia
Most common congenital infection?
Congenital CMV
What is Treponema pallidum?
Syphilis
Spirochete
Baby day 9 has peeling skin, rash on palms and soles and snuffles. What should you be worried about?
Congenital syphilis
What bony changes are found with congenital syphilis?
Periostitis
Specific findings from congenital VZV?
Cicatrial skin lesions
Hypoplastic limbs
CNS + Eyes
Mortality from NEONATAL VZV infection?
~30% (secondary to pneumonitis)
What is the time frame for neonates requiring ZIG if mother develops Primary varicella infection near to delivery?
5 days prior to birth to 48hrs post delivery
If Baby develops chickenpox - give aciclovir
Incidence of GBS disease in AUS?
0.5/1000
Congenital rubella infection has a strong association with which psychiatric disorder?
Autism
