Concept of tissue repair and wound healing Flashcards
it overlaps the inflammatory process
response to tissue injury and represents an attempt to maintain normal body structure and function
Tissue repair and healing
Tissue repair and healing can occur in 3 ways
resolution
regeneration
replacement
is the process that occurs when there is minimal tissue damage
resolution
is the process that occurs in damaged tissue in which the cells are capable of mitosis
regeneration
the process that occurs when there is extensive tissue damage or the cells are incapable of mitosis, injured cells are replaced with connective tissue which leaves a permanent scar (fibrous tissue repair)
replacement
Both organs and tissues are composed of 2 types of structures
Parenchymal tissue
Stromal tissue
contains the functional cells of an organ or body part.
Parenchymal tissue
Body cells are divided into 3 types and undergo regeneration
labile
stable
permanent cells
consists of supporting connective tissues, blood vessels, extracellular matrix and nerve fibres
Stromal tissue
> Regeneration is limited to tissues with cells that are able to undergo mitosis
seen in mild to moderate injury
occurs when damage is limited to parenchymal cells
involves replacement of injured tissue with the cells of the same type (leaving little evidence of previous injury)
Tissue regeneration
Capacity of regeneration varies with the tissue and cell type; Body cells are divided into 3 types according to their ability to undergo regeneration
Labile cells
Stable cells
Permanent or fixed cells
cells that continue to divide and replicate throughout life, replacing cells that are continually being destroyed
include:
> surface epithelial cells of skin, oral cavity, vagina, cervix
> columnar epithelium of GI tract, uterus, fallopian tubes
> transitional epithelium of urinary tract
> bone marrow
Labile cells
cells that normally stop dividing when growth ceases. These cells are capable of undergoing regeneration when confronted with an appropriate stimulus and are capable of reconstituting the tissue of orogin
include:
> parenchymal cells of liver and kidney
> smooth muscle cells
> vascular endothelium cells
Stable cells
cells that cannot undergo mitotic division. These do not regenerate, once destroyed are replaced with fibrous scar tissue that lacks the functional characteristics of the destroyed tissue
include:
> nerve cells
> skeletal muscle cells
> cardiac muscle cells
Permanent or fixed cells