Compendium 9 Flashcards

1
Q

Explain divisions of the spinal cord

A

Divided into cervical, thoracic, lumbar, sacral and coccygeal regions

Diameter changes from top to bottom- enlargements in cervical region and lumbar/sacral region that correspond with nerves that supply limbs
Cervical- supply nerves to arms
Lumbar/sacral- supply nerves to legs

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2
Q

Explain structure of the spinal cord

A

Starts at foramen magnum ends at 1st or 2nd lumbar vertebrae

Pointy end called CONUS MEDULLARIS which finishes at 2nd lumbar vertbrae
Very end region called CAUDA EQUINA which are branches of spinal nerves extending from lumbar/sacral enlargement and conus medullaris (occurs as spinal cord shorter than vertebral canal)

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3
Q

What are meninges

A

Connective tissue covering brain and spinal cord for protection, to hold CSF and to form partitions in the skull

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4
Q

Explain meninges layers in spinal cord

A

Duramata: outermost, thickest, toughest layer- as move deeper into spine there is subdural space that contains serous fluid

Arachnoid mata: thin, fine, loose, elastic - followed by subarachnoid space consigning CSF and blood vessels

Pia mata: tense, contains many blood vessels which tightly surround brain and spinal cord

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5
Q

Explain the structure of nerves in PNS

A

Axon (can be myelinated) covered by connective tissue layer called ENDONERIUM
A bunch of these is called a NERVE FASCICLE
Connective tissue surrounding one fascicle is called PERINERIUM
Outermost layer surrounding a bunch of fascicles is called EPINERIUM

Connective tissue provides strength and protection

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6
Q

How are spinal nerves organised

A

31 pairs arise, only 39 vertebral bones

Top half:
8 cervical nerves (7 bones)
8 thoracic nerves (including remaining 4 thoracic nerves- 12 bones)

Bottom half:
Remaining 4 thoracic nerves
5 lumbar nerves (5 bones)
5 sacral nerves (5 bones)
1 coccygeal nerve (5 fused bones= 1 bone) 

First cervical nerve come out on top of first vertebral bone (C1 on top of bone 1, C2 on top of bone 2)
C8 comes out on top of 1st thoracic bone therefore only 7 cervical bones)
From now on spinal nerves come under corresponding bone (T1 under bone 1)

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7
Q

What are the major parts of the brain

A

Forebrain: cerebrum, diencephalon

Mid brain

Hindbrain: pins, medulla oblongata, cerebellum

Midbrain, points, medulla oblongata form BRAIN STEM

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8
Q

What is the purpose of the brain stem

A

Sits under diencephalon

Connects spinal cord to rest of brain

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9
Q

Describe medulla oblongata

A

Directly connects to spinal cord at foramen magnum
Autonomic reflex centre maintaining body homeostasis
Contains groups of cells:
-cardiovascular centre: heart rate and force, blood vessel diameter
-respiratory centre: rate and depth of breathing
-other reflexes such as vomiting, swallowing, sneezing, coughing, hiccuping

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10
Q

Describe pons

A

Superior to medulla oblongata
Bridges different parts of brain to allow for communication
Contains conduction tracts running in 2 different directions: longitudinal tracts (spinal cord to higher brain centres) and transverse tracts (cerebrum to cerebellum)
Contains sleep centre which regulates rapid eye movement when sleeping
Also part of respiratory centre (works with medulla)

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11
Q

Describe midbrain

A

Smallest part of stem
Receives visual, auditory and tactile sensory input and generates reflex movements of head, eyes and body
Controls eyeball movements

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12
Q

Describe cerebellum

A

Outer grey matter, inner white matter
Highly convoluted
Communications with all of brain stem to control locomotion in association with cerebrum (coordinated movement)
Controls fine motor control e.g. Muscles in wrists, fingers, etc.
Controls posture and balance

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13
Q

Describe diencephalon

A
Contains thalamus (largest part), subthalamus, epithalamus and hypothalamus 
Grey matter
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14
Q

Describe thalamus of diencephalon

A

Paired structure
Sensory relay centre: relays info to cerebrum (sensory information goes here before cerebrum- all senses besides smell)
Regulates mood, memory and strong emotions

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15
Q

Describe hypothalamus of diencephalon

A

Made up of different parts
Maintain homeostasis via endocrine system
Regulates heart rate, digestive activities, sex drive and sexual pleasure
Controls muscles in swallowing, body temp
Regulates mods, motivation, emotions
Regulates sleep wake cycle

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16
Q

Describe cerebrum

A

Most superficial part of brain
Made up of elevated tissue and folds called GYRI and has grooves within called SULCI
Deep grooves called FISSURES
Left and right hemisphere divided by LONGITUDINAL FISSURE - hemisphere connected by bundle of fibres called corpus callosum
LATERAL FISSURE and CENTRAL SULCUS divide hemispheres into lobes

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17
Q

What are the lobes of the cerebrum

A

Frontal: voluntary motor function, motivation, planning, aggression, sense of smell, regulation emotional mood and behaviour

Parietal lobe: receives most sensory input except hearing, smell, taste, and vision (pain, temp, touch, ect.)

Occipital: receives and process visual input

Temporal: smell and heating input and has role in memory

Insula: located deep inside behind lateral fissure- taste information

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18
Q

How are the lobes in the cerebrum separated

A

Lateral fissure separates frontal lobe from rest of cerebrum

Central sulcus separates frontal lobe from parietal lobe

Also precentral gyrus (fold in front of central sulcus in frontal lobe) for primary somatic motor control -particularly fine voluntary movements

Postcentral gyrus/primary somatosensory cortex (fold behind central sulcus in parietal lobe) receives somatic sensory input from receptors in skeletal muscles, joints, tendons and processes it (pain, pressure)
It is first synapses in thalamus before transmitted here

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19
Q

Grey and white matter of cerebrum

A

Grey matter = outer
Where consciousness is formed
Allows us to communicate, remember, understand, ect.

White matter = inner/deep
Communication between cerebral areas and cortex and lower CNS structures

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20
Q

What is the limbic system

A

Runs through medial aspect of hemispheres and diencephalon
Runs around border of corpus callosum
Group of structures that have role in memory, developing new neurological pathways and control emotion and emotional gestures

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21
Q

Describe meninges layers of the brain

A

Dura mata: outermost, fibrous connective tissue that contains the following:

  • periosteal dura: connects to bony skull and also meningeal dura (deeper) which continues with the dura mata of the spinal cord
  • some parts of brain contain these two layers and have a dural venous sinus which contain veins that collect blood that nourishes brain and also dural folds which are connective tissue partitions extending deep into brain which hold brain in place and stop excessive movement
  • if no sinus then two layers fuse together
  • between whole dura mata and next layer there is subdural space with serous fluid

Arachnoid mata: similar structure to in spinal cord- followed by subarachnoid space with CSF and blood vessels

Pia mata: very small blood vessels sit tightly over brain surface

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22
Q

Describe the ventricles of the brain

A

Brain has 4 ventricles that are continuous with each other and are lined with ependymal cells
Largest= lateral ventricle which is paired and extends into each hemisphere
4th is brain stem which is continuous with central canal of spinal cord

These spaces are where CSF is produced

23
Q

Describe cerebrospinal fluid

A

Most produced by choroid plexus which in brain is specialised ependymal cells and support tissue

Protects brain from trauma and provides buoyancy (brain floats which reduces feeling of its weight and takes pressure off structures underneath)

Similar to plasma but less proteins, different ionic concentrations

Some CSF comes from water and solutes in blood moving through ventricles

Provides nutrients to brain and spinal cord

Circulates through ventricles, central canal of spinal cord and subarachnoid space

Cilia of cells help to circulate CSF

24
Q

Describe cranial nerves

A

12 pairs arise from brain

Emerge directly out of brain and carry info from brain to body and back to brain

Can be sensory motor and or parasympathetic functions

25
Q

Describe anatomy of autonomic nervous system

A

Sympathetic division: cell bodies between T1 and L2 called thoracolumbar division

Parasympathetic division: cell bodies in sacral region between S2 and S4 also in cranial nerve nuclei in brain stem called craniosacral region

26
Q

Similarities between parasympathetic and sympathetic divisions

A

Both systems can serve same organs however will have opposing effects

Can both regulate heart rate, blood pressure, airway in lungs, pupil of eye, digestive tract, glands

27
Q

How is the ANS regulated

A

Occurs mostly via autonomic reflexes

Also influenced by CNS particularly in hypothalamus which integrates info which is communicated to other parts of the brain so a response can be executed

28
Q

What is autocrine

A

Released by cells and have local effect on same cell type from which chemical signals released

29
Q

What is paracrine

A

Released by cells and affect other cell types locally without being transported by blood

30
Q

What is an endocrine

A

Produced by cells of endocrine glands, enter circulatory system and affect distant cells

31
Q

What are characteristics of the endocrine system

A

Regulation over time
Glands secrete hormones which are produced in small quantities, transported some distance, act on target tissues elsewhere in body, mostly steroid or amino acid based
Hormone secretion can be:
Acute- sudden release due to stimuli (adrenaline from stress)
Chronic- small variations over long periods (thyroid hormones)
Episodic- e.g. Estrogen and progesterone during menstrual cycle

Target cells respond to hormone as they have correct receptor

32
Q

Similarities between endocrine and nervous systems

A

Both associated with brain
Same chemical messenger can be used as a neurotransmitter and hormone
Are cooperative

33
Q

Differences between endocrine and nervous systems

A

Transport mode (blood vs. axon)
Speed of response
Duration of response

34
Q

How does the CNS control endocrine system

A

CNS can influence hormone release through hypothalamus which synthesis neurohormones and controls release of hormones from anterior pituitary gland
Adrenal medulla arose from neural tissue, secretes adrenaline and noradrenaline
Hypothalamus controls hormone release through releasing and inhibiting hormones it releases itself

35
Q

How does the endocrine system control CNS

A

Endocrine secretes hormones that maintain vernal health of neural tissue, regulates minerals necessary for neural function, needed for growth and function of NS

36
Q

List endocrine glands

A
Pineal gland
Hypothalamus 
Pituitary gland
Thyroid gland
Parathyroid gland
Thymus gland
Adrenal glands
Pancreas
Ovary 
Testes
37
Q

What is a tropic hormone

A

Acts on another endocrine gland which then produces another hormone
Mainly produced by anterior pituitary gland

38
Q

What is a non tropic hormone

A

Hormones that act directly on a target cell to produce an effect
Produced by most endocrine glands

Example: protein synthesis by growth hormones and prolactin acting on breast cells

39
Q

Explain the role of the hypothalamus and pituitary gland

A

Hypothalamus regulates secretions of anterior pituitary
Posterior pituitary is an extension of hypothalamus (nervous tissue)

Pituitary produces 9 major hormones, is a master gland as it produces hormones that act on other glands as well as controlling hormone production

40
Q

Describe structure of pituitary gland

A

Posterior: extends from hypothalamus via infundibulum and secretes neuropeptides that are made by hypothalamus and sent to posterior for release

  • stimuli in NS causes neurons in hypothalamus to increase or decrease frequency of action potentials
  • action potentials conducted along neurons towards posterior, axon terminals of these neurons store neuro-hormones
  • when potential reaches axon terminal neurohormones released into blood stream and travel to target tissue

Anterior: synthesis and secretes hormones
-hypothalamus recognised hormone imbalance or stimulus so produces releasing hormones which travel through capillaries to anterior where hormones will act on particular cells that will produce a certain hormone that acts on a target tissue

41
Q

List anterior pituitary hormones

A
Growth
Thyroid stimulating 
Adrenocorticotropic 
Melanocyte-stimulating
Lutenising hormone and follicle stimulating 
Prolactin
42
Q

Explain growth hormone

A

Acts on most body cells
Stimulated amino acid uptake, fat breakdown, promotes bone and cartilage growth, regulates nutrient levels in blood after meals

43
Q

Explain thyroid stimulating hormone

A

Stimulated thyroid to secrete T3 and T4 which regulate metabolic rate
Influences appetite, temperature, muscle function

44
Q

Explain adrenocorticotropic hormone

A

Stimulate adrenal cortex to secrete cortisol (stress), aldosterone (salt balance and blood pressure) and androgens (development and maintenance of male sex characteristics)

45
Q

Explain melanocytes-stimulating hormone

A

Causes melanocytes to produce more melanin

46
Q

Explain lutenising and follicle stimulating hormone

A

Both regulate production gametes and reproductive hormones

Testosterone in males
Estrogen and progesterone in women

47
Q

Explain prolactin

A

Role in milk production

48
Q

List hormones of posterior pituitary gland

A

Oxytocin

Antidiuretic

49
Q

Explain oxytocin

A

Uterine contractions during birth

Ejection of milk

50
Q

Explain antidiuretic hormone

A

Acts on distal tubule of kidney to increase water reabsorption (less urine produced)

51
Q

Explain negative feedback

A

Anterior pituitary secrete tropic hormone which travels in blood to target endocrine cell
Cell then releases hormone itself and will travel to its target
Hormones effect on target cell will have negative feedback effect on hypothalamus
Message send back to hypothalamus so anterior pituitary decreases secretion of the tropic hormone

52
Q

Explain positive feedback

A

Anterior pituitary secretes tropic hormone will travels in blood to endocrine organ and then to target organ or cell

Positive feedback on hypothalamus and anterior pituitary to increase secretion of tropic hormone

53
Q

How is adrenal medulla different

A

Controlled by sympathetic division NS not pituitary gland