Compendium 9 Flashcards

1
Q

Explain divisions of the spinal cord

A

Divided into cervical, thoracic, lumbar, sacral and coccygeal regions

Diameter changes from top to bottom- enlargements in cervical region and lumbar/sacral region that correspond with nerves that supply limbs
Cervical- supply nerves to arms
Lumbar/sacral- supply nerves to legs

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2
Q

Explain structure of the spinal cord

A

Starts at foramen magnum ends at 1st or 2nd lumbar vertebrae

Pointy end called CONUS MEDULLARIS which finishes at 2nd lumbar vertbrae
Very end region called CAUDA EQUINA which are branches of spinal nerves extending from lumbar/sacral enlargement and conus medullaris (occurs as spinal cord shorter than vertebral canal)

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3
Q

What are meninges

A

Connective tissue covering brain and spinal cord for protection, to hold CSF and to form partitions in the skull

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4
Q

Explain meninges layers in spinal cord

A

Duramata: outermost, thickest, toughest layer- as move deeper into spine there is subdural space that contains serous fluid

Arachnoid mata: thin, fine, loose, elastic - followed by subarachnoid space consigning CSF and blood vessels

Pia mata: tense, contains many blood vessels which tightly surround brain and spinal cord

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5
Q

Explain the structure of nerves in PNS

A

Axon (can be myelinated) covered by connective tissue layer called ENDONERIUM
A bunch of these is called a NERVE FASCICLE
Connective tissue surrounding one fascicle is called PERINERIUM
Outermost layer surrounding a bunch of fascicles is called EPINERIUM

Connective tissue provides strength and protection

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6
Q

How are spinal nerves organised

A

31 pairs arise, only 39 vertebral bones

Top half:
8 cervical nerves (7 bones)
8 thoracic nerves (including remaining 4 thoracic nerves- 12 bones)

Bottom half:
Remaining 4 thoracic nerves
5 lumbar nerves (5 bones)
5 sacral nerves (5 bones)
1 coccygeal nerve (5 fused bones= 1 bone) 

First cervical nerve come out on top of first vertebral bone (C1 on top of bone 1, C2 on top of bone 2)
C8 comes out on top of 1st thoracic bone therefore only 7 cervical bones)
From now on spinal nerves come under corresponding bone (T1 under bone 1)

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7
Q

What are the major parts of the brain

A

Forebrain: cerebrum, diencephalon

Mid brain

Hindbrain: pins, medulla oblongata, cerebellum

Midbrain, points, medulla oblongata form BRAIN STEM

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8
Q

What is the purpose of the brain stem

A

Sits under diencephalon

Connects spinal cord to rest of brain

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9
Q

Describe medulla oblongata

A

Directly connects to spinal cord at foramen magnum
Autonomic reflex centre maintaining body homeostasis
Contains groups of cells:
-cardiovascular centre: heart rate and force, blood vessel diameter
-respiratory centre: rate and depth of breathing
-other reflexes such as vomiting, swallowing, sneezing, coughing, hiccuping

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10
Q

Describe pons

A

Superior to medulla oblongata
Bridges different parts of brain to allow for communication
Contains conduction tracts running in 2 different directions: longitudinal tracts (spinal cord to higher brain centres) and transverse tracts (cerebrum to cerebellum)
Contains sleep centre which regulates rapid eye movement when sleeping
Also part of respiratory centre (works with medulla)

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11
Q

Describe midbrain

A

Smallest part of stem
Receives visual, auditory and tactile sensory input and generates reflex movements of head, eyes and body
Controls eyeball movements

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12
Q

Describe cerebellum

A

Outer grey matter, inner white matter
Highly convoluted
Communications with all of brain stem to control locomotion in association with cerebrum (coordinated movement)
Controls fine motor control e.g. Muscles in wrists, fingers, etc.
Controls posture and balance

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13
Q

Describe diencephalon

A
Contains thalamus (largest part), subthalamus, epithalamus and hypothalamus 
Grey matter
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14
Q

Describe thalamus of diencephalon

A

Paired structure
Sensory relay centre: relays info to cerebrum (sensory information goes here before cerebrum- all senses besides smell)
Regulates mood, memory and strong emotions

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15
Q

Describe hypothalamus of diencephalon

A

Made up of different parts
Maintain homeostasis via endocrine system
Regulates heart rate, digestive activities, sex drive and sexual pleasure
Controls muscles in swallowing, body temp
Regulates mods, motivation, emotions
Regulates sleep wake cycle

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16
Q

Describe cerebrum

A

Most superficial part of brain
Made up of elevated tissue and folds called GYRI and has grooves within called SULCI
Deep grooves called FISSURES
Left and right hemisphere divided by LONGITUDINAL FISSURE - hemisphere connected by bundle of fibres called corpus callosum
LATERAL FISSURE and CENTRAL SULCUS divide hemispheres into lobes

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17
Q

What are the lobes of the cerebrum

A

Frontal: voluntary motor function, motivation, planning, aggression, sense of smell, regulation emotional mood and behaviour

Parietal lobe: receives most sensory input except hearing, smell, taste, and vision (pain, temp, touch, ect.)

Occipital: receives and process visual input

Temporal: smell and heating input and has role in memory

Insula: located deep inside behind lateral fissure- taste information

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18
Q

How are the lobes in the cerebrum separated

A

Lateral fissure separates frontal lobe from rest of cerebrum

Central sulcus separates frontal lobe from parietal lobe

Also precentral gyrus (fold in front of central sulcus in frontal lobe) for primary somatic motor control -particularly fine voluntary movements

Postcentral gyrus/primary somatosensory cortex (fold behind central sulcus in parietal lobe) receives somatic sensory input from receptors in skeletal muscles, joints, tendons and processes it (pain, pressure)
It is first synapses in thalamus before transmitted here

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19
Q

Grey and white matter of cerebrum

A

Grey matter = outer
Where consciousness is formed
Allows us to communicate, remember, understand, ect.

White matter = inner/deep
Communication between cerebral areas and cortex and lower CNS structures

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20
Q

What is the limbic system

A

Runs through medial aspect of hemispheres and diencephalon
Runs around border of corpus callosum
Group of structures that have role in memory, developing new neurological pathways and control emotion and emotional gestures

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21
Q

Describe meninges layers of the brain

A

Dura mata: outermost, fibrous connective tissue that contains the following:

  • periosteal dura: connects to bony skull and also meningeal dura (deeper) which continues with the dura mata of the spinal cord
  • some parts of brain contain these two layers and have a dural venous sinus which contain veins that collect blood that nourishes brain and also dural folds which are connective tissue partitions extending deep into brain which hold brain in place and stop excessive movement
  • if no sinus then two layers fuse together
  • between whole dura mata and next layer there is subdural space with serous fluid

Arachnoid mata: similar structure to in spinal cord- followed by subarachnoid space with CSF and blood vessels

Pia mata: very small blood vessels sit tightly over brain surface

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22
Q

Describe the ventricles of the brain

A

Brain has 4 ventricles that are continuous with each other and are lined with ependymal cells
Largest= lateral ventricle which is paired and extends into each hemisphere
4th is brain stem which is continuous with central canal of spinal cord

These spaces are where CSF is produced

23
Q

Describe cerebrospinal fluid

A

Most produced by choroid plexus which in brain is specialised ependymal cells and support tissue

Protects brain from trauma and provides buoyancy (brain floats which reduces feeling of its weight and takes pressure off structures underneath)

Similar to plasma but less proteins, different ionic concentrations

Some CSF comes from water and solutes in blood moving through ventricles

Provides nutrients to brain and spinal cord

Circulates through ventricles, central canal of spinal cord and subarachnoid space

Cilia of cells help to circulate CSF

24
Q

Describe cranial nerves

A

12 pairs arise from brain

Emerge directly out of brain and carry info from brain to body and back to brain

Can be sensory motor and or parasympathetic functions

25
Describe anatomy of autonomic nervous system
Sympathetic division: cell bodies between T1 and L2 called thoracolumbar division Parasympathetic division: cell bodies in sacral region between S2 and S4 also in cranial nerve nuclei in brain stem called craniosacral region
26
Similarities between parasympathetic and sympathetic divisions
Both systems can serve same organs however will have opposing effects Can both regulate heart rate, blood pressure, airway in lungs, pupil of eye, digestive tract, glands
27
How is the ANS regulated
Occurs mostly via autonomic reflexes Also influenced by CNS particularly in hypothalamus which integrates info which is communicated to other parts of the brain so a response can be executed
28
What is autocrine
Released by cells and have local effect on same cell type from which chemical signals released
29
What is paracrine
Released by cells and affect other cell types locally without being transported by blood
30
What is an endocrine
Produced by cells of endocrine glands, enter circulatory system and affect distant cells
31
What are characteristics of the endocrine system
Regulation over time Glands secrete hormones which are produced in small quantities, transported some distance, act on target tissues elsewhere in body, mostly steroid or amino acid based Hormone secretion can be: Acute- sudden release due to stimuli (adrenaline from stress) Chronic- small variations over long periods (thyroid hormones) Episodic- e.g. Estrogen and progesterone during menstrual cycle Target cells respond to hormone as they have correct receptor
32
Similarities between endocrine and nervous systems
Both associated with brain Same chemical messenger can be used as a neurotransmitter and hormone Are cooperative
33
Differences between endocrine and nervous systems
Transport mode (blood vs. axon) Speed of response Duration of response
34
How does the CNS control endocrine system
CNS can influence hormone release through hypothalamus which synthesis neurohormones and controls release of hormones from anterior pituitary gland Adrenal medulla arose from neural tissue, secretes adrenaline and noradrenaline Hypothalamus controls hormone release through releasing and inhibiting hormones it releases itself
35
How does the endocrine system control CNS
Endocrine secretes hormones that maintain vernal health of neural tissue, regulates minerals necessary for neural function, needed for growth and function of NS
36
List endocrine glands
``` Pineal gland Hypothalamus Pituitary gland Thyroid gland Parathyroid gland Thymus gland Adrenal glands Pancreas Ovary Testes ```
37
What is a tropic hormone
Acts on another endocrine gland which then produces another hormone Mainly produced by anterior pituitary gland
38
What is a non tropic hormone
Hormones that act directly on a target cell to produce an effect Produced by most endocrine glands Example: protein synthesis by growth hormones and prolactin acting on breast cells
39
Explain the role of the hypothalamus and pituitary gland
Hypothalamus regulates secretions of anterior pituitary Posterior pituitary is an extension of hypothalamus (nervous tissue) Pituitary produces 9 major hormones, is a master gland as it produces hormones that act on other glands as well as controlling hormone production
40
Describe structure of pituitary gland
Posterior: extends from hypothalamus via infundibulum and secretes neuropeptides that are made by hypothalamus and sent to posterior for release - stimuli in NS causes neurons in hypothalamus to increase or decrease frequency of action potentials - action potentials conducted along neurons towards posterior, axon terminals of these neurons store neuro-hormones - when potential reaches axon terminal neurohormones released into blood stream and travel to target tissue Anterior: synthesis and secretes hormones -hypothalamus recognised hormone imbalance or stimulus so produces releasing hormones which travel through capillaries to anterior where hormones will act on particular cells that will produce a certain hormone that acts on a target tissue
41
List anterior pituitary hormones
``` Growth Thyroid stimulating Adrenocorticotropic Melanocyte-stimulating Lutenising hormone and follicle stimulating Prolactin ```
42
Explain growth hormone
Acts on most body cells Stimulated amino acid uptake, fat breakdown, promotes bone and cartilage growth, regulates nutrient levels in blood after meals
43
Explain thyroid stimulating hormone
Stimulated thyroid to secrete T3 and T4 which regulate metabolic rate Influences appetite, temperature, muscle function
44
Explain adrenocorticotropic hormone
Stimulate adrenal cortex to secrete cortisol (stress), aldosterone (salt balance and blood pressure) and androgens (development and maintenance of male sex characteristics)
45
Explain melanocytes-stimulating hormone
Causes melanocytes to produce more melanin
46
Explain lutenising and follicle stimulating hormone
Both regulate production gametes and reproductive hormones Testosterone in males Estrogen and progesterone in women
47
Explain prolactin
Role in milk production
48
List hormones of posterior pituitary gland
Oxytocin | Antidiuretic
49
Explain oxytocin
Uterine contractions during birth | Ejection of milk
50
Explain antidiuretic hormone
Acts on distal tubule of kidney to increase water reabsorption (less urine produced)
51
Explain negative feedback
Anterior pituitary secrete tropic hormone which travels in blood to target endocrine cell Cell then releases hormone itself and will travel to its target Hormones effect on target cell will have negative feedback effect on hypothalamus Message send back to hypothalamus so anterior pituitary decreases secretion of the tropic hormone
52
Explain positive feedback
Anterior pituitary secretes tropic hormone will travels in blood to endocrine organ and then to target organ or cell Positive feedback on hypothalamus and anterior pituitary to increase secretion of tropic hormone
53
How is adrenal medulla different
Controlled by sympathetic division NS not pituitary gland