Companion Animal Treatments and Procedures I Flashcards
Canine vaccination
Core: 1st 8 w; 2nd 3 w later -> yearly (3rd > 16 w age; 4th 26 w/52 w -> q 3 y)
- D - Canine distemper virus (CDV)
- H - Canine adenovirus (CAV) (hepatitis)
- P - Canine parvovirus type 2 (CPV)
- (Rabies in endemic countries)
Non-core:
- Pi - Canine parainfluenza virus
- Bb - Bordetella bronchiseptica
- L - Leptospirosis (multiple serovars) (yearly), core in UK
- Borrelia burgdorferi (Lyme disease); Canine herpes virus; Leishmaniasis; Rabies (UK)
Not-recommended:
- Canine enteric coronavirus
Feline vaccination
Core: kitten - 1st 8 w; 2nd 12 w -> annually (three yearly vacc protocols)
- ‘Cat flu’, q 1 y: Feline calicivirus (C); Feline herpesvirus type 1 (rhinotracheitis) (R)
- Feline parvovirus, enteritis (P)
- Rabies (endemic)
Non-core:
- Feline leukaemia virus (FeLV), q 3 y
- Chlamydia (Chlamydia felis)
- Bordetella bronchiseptica (Bb) (KC)
- Rabies (UK)
Feline immunodeficiency virus (FIV) (not available in UK)
Not recommended:
- Feline infectious peritonitis (FIP) (not available in UK)
Leptospirosis - prevention (canine)
- Annual vaccs w/ tetravalent vaccine
Kennel cough (canine parainfluenza virus (Pis)/Bordetella bronchiseptica (Bb) antigen (canine)
- Intranasal injection = live vacc (shedding up to 35 d, avoid AB use 14 d post-vacc)
- Subcut (only Bb), need adjuvant for Pi
Leishmaniasis (canine)
- CaniLeish vacc (Virbac)
- Reduces risk of infection by promoting cell mediated immunity
- Give to healthy seronegative dogs when at high risk
Borrelia (Lyme disease) (canine)
- Vacc controversy
- Acaricide - takes 24 h for attachment of tick to transfer Borrelia
Canine herpes (canine)
- Eurican Herpes 205 (Boeringer)
- Pregnant bitches -> passive protection for puppies in first few days of life - Ab
- 1st = 7 - 10 d after mating date
- 2nd 1 - 2 w before expected whelping
Endoparasites
Nematodes + Cestodes
- Macrocyclic lactones - Milbemycin oxime, moxidectin, selamectin (Stronghold)
- Benzimidazoles - Fenbendazole (Panacur), febantel
Consider:
- Roundworms: Tx puppies 2, 5, 8 w, then q month until 6 m/o; pregnant bitches (fenbendazole (Panacur) SID from day 40 until 2 w post-partum / ML on d 40 + 55; sharing homes w/ young children/immunosuppressed (monthly); show/sport/kennels (1 m before, 2 - 4 w after event)
- Tapeworms: travel; raw-fed dogs (q 6 w); flea infestation - flea swallowed w/ containing tapeworm larvaew/ Praziquantel
Dipylidium sp tapeworm endoparasite (canine)
- Praziquantel - not controlled
Ectoparasites
1). Ectoparasiticides
- Macrocyclic lactones (milbemycin, moxidectin)
- Phenylpyrazoles (fipronil)
- Imidacloprid / nitenpyram
- Pyrethroids (permethrin)
- Amitraz
- Isoxazolines (Advocate, Advantgae, Bravecto) - treats most things but tapeworms + ticks
2). Acaricides (mites and ticks)
3). Insecticides (insects)
4). Growth regulators - e.g. Permethrin
5). Methoprene (juvenile hormone analogue)
6). Lufenuron (insect development inhibitor)
Postponement of estrus/heat
- Progestogens (P4 analogues -> dec in GnRH, FSH, LH, E2): Megestrol acetate (Ovarid); Proligestone (Delvosteron)
- Androgens (-ive feedback on HPG axis, tissues less responsive to E2): Milbolerone; Nandrolone (given for CRF in cats); Testosterone (not in UK)
- GnRH agonists (dec FSH + LH production), desensitises GnRH production - Deslorelin acetate
- Surgical - OVH, ovariectomy, tube ligation
- Intrauterine - intrauterine devices
Misalliance/pregnancy termination
1). Drugs acting on uterus: Aglepristone (Alizin) - anti-progestogen, synthetic steroid
- Early preg (0 - 22 d) - vag cyto in dioestrus
- 2). Drugs acting on ovaries: Prostaglandin (Dinoprost) (PGF2/PGF2a) - lyse CL (but in dog, CL resistant to effects), cause uterine contractions
- Mid preg (22 - 40 d) - if +ive preg Dx, w/ Aglepristone
- 3). Drugs acting on pit gland: Cabergoline (Galastop) - dopamine agonist, inhibits prolactin production -> luteolysis
- Late preg (> 40 d) / still +ive / all three or OVH
Pseudopregnancy (canine)
- Conservative - inc exercise, disrupt nesting, distract from toys
- Cabergoline (Galastop) - dopamine agonist (dec prolactin production)
- Likely recurrent -> OVH (3 - 4 m after season/post whelping)
- Avoid spay at time of elevated/rising prolactin as may result in prolonged pseudopreg - wait 8 - 10 w
Induction of parturition
- Un-licensed drugs, used for abortion/pyo Tx
- Risk of maternal morbidity, dystocia, should not be induced before d 60
- Aglepristone, oxytocin
- Aglepristone, PGF2a
- Nitroglycerine (softens cervix), oxytocin
Control of male breeding cycle
- Surgical - castration, vasectomy
Chemical:
- GnRH agonists - Deslorelin (Suprelorin) - slow release, long-acting implant; causes initial 14 d testosterone surge, then levels dec, infertility after 6 - 8 w implantation, lasts up to 6 - 12 m, longer in lighter dogs
- Progestogens - Delmadinone acetate (Tardak) - for hypersexuality, prostatic hyperplasia
- Androgens - Testosterone (Durateston) - dec spermatozoa + spermatozoal motility, SE: prostatic hypertrophy; not licensed for use for control of breeding in males
- Prolactin - dec fertility - reduced motility, no. + altered structure of spermatozoa (serum conc of testosterone, FSH and LH do not alter), possibly a direct effect on testes rather than HPG axis, not licensed
- Immunisterilisation - w/ Improvac, targets GnRH, LH + sperm antifens (AB production unpredictable, GnRH/LH not immunogenic)
Other:
- Injection: intratesticular, intra-epididymal, intra-vas deferens injections; adjuvant agent (BCG); reproductive toxins (dexamethasone); Zinc gluconate; Occlusive silicone (vas deferens) (varying degrees of reduction/duration of infertility)
- US - high intensity focused US beam, short bursts (10 - 15 min 1 - 3 times from 2 - 7 d), suppresses spermatogenesis without affecting testosterone levels
Induction of infertility (ferrets)
- Deslorelin (Suprelorin)
Ovarian cysts (guinea pig)
- Deslorelin (Suprelorin)
Oestrogen-induced mammary carcinoma (rat)
- Deslorelin (Suprelorin)
Egg-laying disorders (egg binding) (birds)
- Deslorelin (Suprelorin)
Obstructive dystocia
- 1). Manual intervention - large dogs - retropulsion/realignment (transabdominal palp)+ traction techniques to push foetus back into uterus then reposition + pull head out in between straining
- Traction - a lot of lube + grip head only (only use forceps if deceased)
- No success -> Sx
Non-obstructive dystocia - medical management
- Only if no obstruction; dam is physically healthy; no signs of foetal distress
- Oxytocin (0.2 - 0.4 IU/animal SC/IM) - repeat 20 - 3- min x 3
- 10% calcium gluconate 0.5 - 1.5 mL/kg slow IV 1 mL/min w/ ECG + HR monitoring, dilute in saline, strengthen uterine contractions
- 2 mL of 50% dextrose by slow IV infusion (for hypoglycaemia)
(Less successful in the queen)
Caesarian section
- If non-responsive medical management
- Foetal distress evident despite inc in uterine contractibility
- Unsuccessful attempt at relieving obstruction
Hypocalcaemia (peri-parturient disease) - eclampsia, puerperal tetany
- Treat immediately - risk of seizing + death
- Calcium gluconate 10% slow (0.5 - 1.5 mL/kg) (cats = 0.5 - 1.0 mL per cat IV)
- Cooling if hyperthermic
- Give O2
- Continue calcium supplementation w/ dilute calcium gluconate SC or oral calcium + vit D supplementation
- Consider weaning pups if possible
Hypoglycaemia (peri-parturient disease)
- 50% dextrose slow IV (0.5 - 1g/kg, 1 - 2 mL/kg), dilute in saline 1:4
- Supplement feeding until parturition
Hyperglycaemia (peri-parturient disease) - gestational diabetes
- Difficult to manage - consider termination of pregnancy
- No further breeding
Metritis (peri-parturient disease)
- Stabilise dam -> IVFT, IV broad spectrum AB (consider choice if nursing)
- Evacuate uterine contents -> uterine lavage, oxytocin, PGF2a
- Consider OVH in severe cases
Haemorrhage (peri-parturient disease)
- Repair defect - e.g. tearing (uterine/vaginal), vessel rupture, underlying coagulation defect
- Vaginal packing
- Oxytocin
- Blood transfusion
- Exploratory laparotomy
Small uterine prolapse w/ minimal uterine damage
- Clean w/ saline
- Lubricate + gently replace under sedation/GA
- Hypertonic fluids
- Oxytocin
Severe uterine prolapse/damage
- Restore blood vol (due to haemorrhage + shock) -> IVFT/blood transfusion
- Exploratory laparotomy +/- OVH
Mastitis (peri-parturient disease)
- Systemic AB - Amoxicillin + clavulanic acid
- Warm compress/massage/stripping + pain med
- Sx debridement if abscessation
- Sepsis Tx
- Management of neonates
Neonatal resuscitation ABCD
- 1). Airway - clear airway - gauze/cotton swab/suction pipette (or syringe attached to IV cannula)
- 2). Breathing - stimulate by vigorous rubbing, gentle chest compression, doxapram (NSAID, not used anymore)
- Supply O2 - flow by mask/intubation
- Induction apnoea acupuncture point between midline of philtrum + twist
- 3). Circulation - cardiac massage (CPR), fluid therapy
- 4). Dry and warm - dry + provide heat source, blankets
Fading puppy or kitten syndrome
- Treat underlying cause/problem - rule out congenital defects, nutritional deficiencies, traumatic injury, maternal neglect, infectious diseases, septicaemia
- Supportive care ASAP
- May require fluids, glucose, nutrition, warming, AB, vit K1 in haemorrhage w/ prolonged PT (prothrombin/clotting time)
Antimicrobial therapy - neonates
- AB therapy (IV preferred) - amoxicillin (10 - 20 mg/kg BID); amoxicillin/clavulanic acid (12 - 25 mg/kg BID); Cephalexin (10 - 30 mg/kg BID)
(Don’t give aminoglycosides - gentamycin, amikacin - renal damage; chloramphenicol -> BM suppression; quinolones - enrofloxacin -> cartilage damage esp in large dog breeds)
Omphalitis
- Drain abscess
- AB
- Nursing
- Feeding
- Fluids
Ophthalmia neonatorum (conjunctivitis)
- Open eyes carefully + flush
- AB ointment
Neonatal isoerythrolysis
- CATS (not seen in dogs unless bitch had blood transfusion before)
- Proper breeding program of pure-breeds - blood type kittens at birth + hand-rear A + AB kittens (if mother B type - have anti-A Ab in milk) then return to mother after GI barrier (colostrum closed up after 24 h)
- Use foster cat mother
Neonatal septicaemia
- Culture peritoneal fluid
- Treat litter mates early - cephalosporins sometimes combined w/ enrofloxacin (weigh up pros + cons of quinolone usage)
Neonatal hypothermia
- Rewarm slowly over 1 - 2 h to avoid inc metabolic demand/avoid shock
- Focal source of heat - hot water bottle, rice bags, no direct contact able to move away (no heat lamp/mat)
- Bair hugger
- Turn regularly
- 29 - 31 C w 1
- 26 - 28 C w 2
- 23 - 25 C > w 3
Neonatal hypoxia
- Pulse oximeter reading = ~90%, give 50% O2 maximum
Neonatal dehydration
- Fluids - PO/SC/IP/intra-osseus (femur/humerus)/IV
- Maintenance = 80 - 100 mL/kg/day
Neonatal hypoglycaemia
- Feed
- 0.5 - 1.5 mL/kg 50 % dextrose diluted 1:1 orally or IV - CRI to maintain euglycaemia