Comorbidites: other things Flashcards
NUTRITION AND NEUROLOGICAL DISEASE
:D
Do you need to know the mechanisms causing neuronal death, and repair?
Gut brain axis and Alzheimer’s disease:
- Gut microbiota are a large source of ______
- Compare bacterial and CNS amyloids in terms of their primary and tertiary structure
- Curli producing bacteria have incresaed expression of ____, which is found in amyloid plaques
Amyloids
Different primary but similar tertiary structure
TLR2
Parkinson’s disease and gut brain axis:
Rats exposed to curli producing E coli displayed:
-Increased _____ _______ in the ___ and ___
Increased numbers of _______and ______ compared to rats exposed to non curcli producing E coli
Alpha synuclein
Brain and gut
Microglia and astrocytes
Schizophrenia and gut-brain axis:
Do people with schizophrenia have altered gut microbiota?
What happens to schizophrenia behaviours when rats have gut microbiome transplants from people with schizophrenia?
In these mice, are there different metabolic pathways in the microbiota
Yes
More behaviours
Yes
Ghrelin: do you need to know
-Des-acylated and acylated forms
Functions beyond increased food intake
Yes
Ghrelin and Parkinson’s disease: does exogenous and endogenous ghrelin counteract loss of tyrosine hydroxylase secreting neurons in tne SNpc, and incresae striatal dopamine concentration?
Yes
ASTHMA AND OBESITY
:D
Do you need to know obesity statistics
Yes
Can obesity both cause and complicate asthma?
Obesity associated asthma is driven by which Th cells?
Yes
Th1
Is obesity associated with an increased risk of a new asthma diagnosis?
Is there a dose response in terms of BMI and odds of asthma diagnosis?
Yes
Yes
What are the 3 mechanisms through which obesity causes asthma?
Do you need to know these in detail?
Obesity impairs lung function
Obesity causes inflammation
Obesity causes oxidative stress
Yes
Do you need to know additional factors contributing to asthma and obesity
Yes
What are the 2 mechanisms through which obesity reduces dilator response to asthma?
Reduced lung function
Oxidative stress
What is the mechanism through which obesity reduces responsiveness to anti inflammatory therapy?
Inflammation
Do you need to know the studies on:
- How physical activity contributes to asthma alleviation
- How bariatric surgery contributes to ashtma allieviation
- Yes Yes
RESPIRATORY AND NEUROLOGICAL DISEASE
:D
Do you need to know what happens to neurons during waking hours and sleep
Yes
Are sleep disorders frequent after stroke?
Do you need to know the mechanisms linking insufficient sleep to worse outcomes after stroke
Is sleep neuroprotective in stroke and promotes neuroplasticity?
Yes
Yes
Yes
Do you need to know the studies about:
- Sleep deprivation and cerebral infarct area
- Sleep following stroke and reactive astrocytes and neurocan
- Axon sprouting in non sleep deprived rats after stroke
- Synaptogenesis in sham/ischemic sleep deprived or not rats
Yes
Alzheimers and sleep deprivation: Do you need to know
- Changes in sleep that occur with dementia
- Medications that contribute to insomnia in dementia patients
Yes
Does disrupted sleep lead to increased alpha beta levels and phosphorylated tau levels, in turn leading to further sleep disruption?
Yes
Do you need to know about sleep intensification in Alzheimer’s rats study
Yes
Do people with neurological conditions have increased risk of OSA
Is there an assocation with childhood OSA with chronic conditions?
Is there a link between ADHD and OSA?
Yes
Yes
Yes
Do you need to know how air pollution contributes to
- STroke
- Dementia
- Atrial fibrillation
Yes
