Comorbidites: other things

Question 1

NUTRITION AND NEUROLOGICAL DISEASE

Answer 1

:D

Question 2

Do you need to know the mechanisms causing neuronal death, and repair?

Question 3

Gut brain axis and Alzheimer’s disease:

• Gut microbiota are a large source of ______
• Compare bacterial and CNS amyloids in terms of their primary and tertiary structure
• Curli producing bacteria have incresaed expression of ____, which is found in amyloid plaques

Answer 3

Amyloids
Different primary but similar tertiary structure
TLR2

Question 4

Parkinson’s disease and gut brain axis:
Rats exposed to curli producing E coli displayed:
-Increased _____ _______ in the ___ and ___
Increased numbers of _______and ______ compared to rats exposed to non curcli producing E coli

Answer 4

Alpha synuclein
Brain and gut
Microglia and astrocytes

Question 5

Schizophrenia and gut-brain axis:
Do people with schizophrenia have altered gut microbiota?
What happens to schizophrenia behaviours when rats have gut microbiome transplants from people with schizophrenia?
In these mice, are there different metabolic pathways in the microbiota

Answer 5

Yes
More behaviours
Yes

Question 6

Ghrelin: do you need to know
-Des-acylated and acylated forms
Functions beyond increased food intake

Answer 6

Yes

Question 7

Ghrelin and Parkinson’s disease: does exogenous and endogenous ghrelin counteract loss of tyrosine hydroxylase secreting neurons in tne SNpc, and incresae striatal dopamine concentration?

Answer 7

Yes

Question 8

ASTHMA AND OBESITY

Answer 8

:D

Question 9

Do you need to know obesity statistics

Answer 9

Yes

Question 10

Can obesity both cause and complicate asthma?

Obesity associated asthma is driven by which Th cells?

Answer 10

Yes

Th1

Question 11

Is obesity associated with an increased risk of a new asthma diagnosis?
Is there a dose response in terms of BMI and odds of asthma diagnosis?

Answer 11

Yes

Yes

Question 12

What are the 3 mechanisms through which obesity causes asthma?
Do you need to know these in detail?

Answer 12

Obesity impairs lung function
Obesity causes inflammation
Obesity causes oxidative stress
Yes

Question 13

Do you need to know additional factors contributing to asthma and obesity

Answer 13

Yes

Question 14

What are the 2 mechanisms through which obesity reduces dilator response to asthma?

Answer 14

Reduced lung function

Oxidative stress

Question 15

What is the mechanism through which obesity reduces responsiveness to anti inflammatory therapy?

Answer 15

Inflammation

Question 16

Do you need to know the studies on:

• How physical activity contributes to asthma alleviation
• How bariatric surgery contributes to ashtma allieviation

Answer 16

• Yes Yes

Question 17

RESPIRATORY AND NEUROLOGICAL DISEASE

Answer 17

:D

Question 18

Do you need to know what happens to neurons during waking hours and sleep

Answer 18

Yes

Question 19

Are sleep disorders frequent after stroke?
Do you need to know the mechanisms linking insufficient sleep to worse outcomes after stroke
Is sleep neuroprotective in stroke and promotes neuroplasticity?

Answer 19

Yes
Yes
Yes

Question 20

Do you need to know the studies about:

• Sleep deprivation and cerebral infarct area
• Sleep following stroke and reactive astrocytes and neurocan
• Axon sprouting in non sleep deprived rats after stroke
• Synaptogenesis in sham/ischemic sleep deprived or not rats

Answer 20

Yes

Question 21

Alzheimers and sleep deprivation: Do you need to know

• Changes in sleep that occur with dementia
• Medications that contribute to insomnia in dementia patients

Answer 21

Yes

Question 22

Does disrupted sleep lead to increased alpha beta levels and phosphorylated tau levels, in turn leading to further sleep disruption?

Answer 22

Yes

Question 23

Do you need to know about sleep intensification in Alzheimer’s rats study

Answer 23

Yes

Question 24

Do people with neurological conditions have increased risk of OSA
Is there an assocation with childhood OSA with chronic conditions?
Is there a link between ADHD and OSA?

Answer 24

Yes
Yes
Yes

Question 25

Do you need to know how air pollution contributes to

• STroke
• Dementia
• Atrial fibrillation

Answer 25

Yes