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NAPLEX > Commonly Used/Active Drugs for Specific Pathogens > Flashcards

Commonly Used/Active Drugs for Specific Pathogens Flashcards

1
Q

Methicillin-sensitive Staphylococcus Aureus

MSSA

A
  • Dicloxacillin, nafcillin, oxacillin
  • Cefazolin, cephalexin (+ other 1st and 2nd gen)
  • Amox/clav, amp/sulb
  • Doxy, minocycline
  • SMX/TMP
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2
Q

Community acquired Methicillin-resistant Staphylococcus Aureus, Skin and Soft Tissue Infections
(CA-MRSA) (SSTI)

A
  • SMX/TMP
  • Doxy, minocycline
  • Clindamycin (d-test)
  • Linezolid
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3
Q

Severe SSTIs requiring IV tx or hospitalization (Cover MRSA and Streptococci)

A
  • Vanco (consider using alt if MIC >=2)
  • Linezolid, tedizolid
  • Daptomycin
  • Ceftaroline
  • Telavancin, oritavancin, dalbavancin
  • Quinupristin/Dalfopristin
  • Tigecycline
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4
Q

Nosocomial MRSA

A
  • Vanco (consider using alt if MIC >=2)
  • Linezolid
  • Daptomycin (not in pneumonia)
  • Telavancin
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5
Q

VRE (E. Faecalis)

A
  • Pen G or Ampicillin
  • Linezolid
  • Daptomycin
  • Tigecycline

Cystitis only: nitrofurantoin, fosfomycin, doxycycline

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6
Q

VRE (E. faecium)

A
  • Daptomycin
  • Linezolid
  • Quinupristin/dalfopristin
  • Tigecycline

Cystitis only: nitrofurantoin, fosfomycin, doxycycline

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7
Q

HNPEK

A
  • Beta-lactam/beta-lactamase inhibitor
  • Amoxicillin (if beta-lactamase negative)
  • Cephalosporins (except 1st gen)
  • Carbapenems
  • SMX/TMP
  • Aminoglycosides
  • Quinolones
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8
Q

Atypical Organisms

A
  • Azithromycin, clarithromycin
  • Doxycycline, minocycline
  • Quinolones
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9
Q

Pseudomonas aeruginosa

A
  • pip/tazo (zosyn)
  • Cefepime
  • Ceftazidime
  • Ceftazidime/avibactam
  • Ceftolazone/tazobactam
  • Carbapenems (except ertapenem)
  • Ciprofloxacin, levofloxacin
  • Aztreonam
  • Aminoglycosides
  • Colistimethate, polymixin
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10
Q

Acinetobacter baumannii

A
  • Carbapenems (except ertapenem)
  • Ampicillin/sulbactam
  • Minocycline
  • Tigecycline
  • Quinolones
  • SMX/TMP
  • Amikacin
  • Colistimethate, polymixin
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11
Q

ESBL Gram-negative rods (GNR)- E. coli, K. pneumoniae, P. mirabilis

A
  • Carbapenems
  • Ceftazidime/avibactam
  • Ceftolozan/tazobactam
  • Aminoglycosides

Cystitis only: fosfomycin

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12
Q

Carbapenem-resistant gram-negative rods (CRE)

A
  • Ceftazidime/avibactam
  • Colistimethate, polymixin B
  • Meropenem/vaboractam
  • Imipenem/cilastatin/relebactam
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13
Q

Bacteroides fragilis

A
  • Metronidazole
  • Beta-lactams/beta-lactamase inhibitors
  • Cefotetan, cefoxitin
  • Carbapenems
  • Tigecycline

Other (reduced activity): moxifloxacin

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14
Q

C.Diff

A
  • Vanco oral
  • Fidaxomicin
  • Metronidazole
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NAPLEX (45 decks)

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