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NAPLEX > Chapter 53: Acute and Critical Care Medicine > Flashcards

Chapter 53: Acute and Critical Care Medicine Flashcards

1
Q

Crystalloids

A
  • D5W
  • NS
  • LR (contains NaCl, KCl, CaCl2, Na-lactate)
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2
Q

Colloids

A

Albumin 5%, 25% (Albutein, AlbuRX)

Stay in intravascular space and increase oncotic pressure

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3
Q

Hyponatremia

A

Na<35meq/l
Correcting more rapidly than 12meq/l over 24 hours can cause osmotic demyelination syndrome (ODS) or central pontine myelinolysis which can cause paralysis, seizures, and death.

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4
Q

Hypotonic Hypovolemic Hyponatremia

A

Can be cause by diuretics, blood-loss, vomiting, diarrhea.

Treatment is to correct cause and administer NaCl IV solutions

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5
Q

Hypotonic Hypervolemic Hyponatremia

A

Cause by fluid overload (cirrhosis, HF, or renal failure)

Treatment is diuresis with fluid restriction

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6
Q

Arginine Vasopressin (AVP) receptor antagonists

A

Conivaptan and Tolvaptan
May be used to treat SIADH and hypervolemic hyponatremia.
They increase excretion of free water while maintaining sodium

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7
Q

Tolvaptan

A

Limited to <=30 days use due to hepatoxicity
Boxed warning: Should be initiated in a hospital, rapid over correcting can cause ODS
SE: thirst, nausea, dry mouth, polyuria

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8
Q

Hypernatremia

A

NA>=145meq/l

Associated with water deficit and hypertonicity

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9
Q

Hypokalemia

A

K<3.5meq/l

In general a drop of 1 meq/l in serum K below 3.5 represents a total body deficit of 100-400 meq

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10
Q

K replacement

A

Safe administration through a peripheral IV line include a max infusion rate of <=10 meq/hr and a max concentration of 10 meq/100ml
IV K can be fatal if administered undiluted or through IV push
Magnesium is necessary for K uptake

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11
Q

Hypomagnesium

A

Mg<1.3 meq/l
When serum Mg is <1 meq/l with life-threatening symptoms (seizures, arrhythmias) IV replacement is recommended. Magnesium Sulfate is used for IV replacement.
When serum Mg is >1 meq/l and <1.5 Mg can be replaced orally, most commonly with Mg Ox

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12
Q

Hypophosphatemia

A

Considered severe and is usually symptomatic when serum PO4 is < 1 mg/dL, IV PO4 is used for replacement.

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13
Q

Intravenous Immunoglobulins

A

Carimune NF, Flebogamma DIF, Gammagard, Gamunex-C, Octagam, Privigen
-Use slower infusion rate in renal and CV disease

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14
Q

APACHE II

A

The Acute Physiologic Assessment and Chronic Health Evaluation II: scoring tool used to determine prognosis and ICU mortality risk

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15
Q

Vasopressors

A

Most work by stimulating alpha receptors which causes vasoconstriction and increases systemic vascular resistance (SVR) which increases BP

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16
Q

Dopamine MOA

A

Dependent on dose

  • Low (renal) dose: 1-4mcg/kg/min (dopamine-1 agonist)
  • Medium dose: 5-10mcg/kg/min (beta-1 agonist)
  • High dose: 10-20mcg/kg/min (alpha-1 agonist)
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17
Q

Epinephrine

A

Adrenaline

Alpha-1, Beta-1, and beta-2 agonist

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18
Q

Norepinephrine

A

Levophed

Alpha-1 agonist activity > beta-1 agonist activity

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19
Q

Phenylephrine

A

Neo-synephrine

Alpha-1 agonist

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20
Q

Vasopressin

A

Vasostrict

Vasopressin receptor agonist

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21
Q

Vasopressors warnings, SE, notes

A

Boxed warnings: all vasopressors are vesicants, when administered IV, treat extravasation with phentolamine
SE: arrhythmias, tachycardia, necrosis (gangrene), bradycardia (phentolamine), hyperglycemia (epinephrine)
Notes: solutions should not be used if they are discolored or contain a precipitate, should be administered through central line, epinephrine used for IV push is 0.1mg/ml (1:10,000) and IM is 1mg/ml (1:1,000)

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22
Q

Phentolamine

A

Alpha-1 blocker that antagonizes the effects of the vasopressor

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23
Q

Nitroglycerin uses

A

Often used when there is active myocardial ischemia, or uncontrolled HTN but effectiveness may be limited to 24-48 hrs due to tachyphylaxis (tolerance)

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24
Q

Nitroprusside MOA and uses

A

It is a mixed (equal) arterial and venous vasodilator at all doses.
Should not be used it active myocardial ischemia because it can cause blood to be diverted away from diseased coronary arteries (“coronary steal”)

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25
Q

Nitroprusside toxicity

A

Metabolism results in thiocyanate and cyanide formation which can cause toxicity. Hydroxocobalamin can be administered to reduce risk and sodium thiosulfate + sodium nitrite (Nithiodote) is used for cyanide toxicity

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26
Q

Nitroglycerin MOA, CI, SE

A

MOA: low doses is a venous vasodilator; high doses is a arterial vasodilator
CI: SBP<90, use with PDE-5 inhibitor
SE: HA, tachycardia, tachyphlaxis
Notes: requires non-pvc container (glass, polyolefin)

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27
Q

Nitroprusside warnings, SE, notes

A

Boxed warning: metabolism produced cyanide, excessive hypotension, must be diluted (D5W preferred)
Warning: increased ICP
SE: HA, tachycardia, thiocyanate/cyanide toxicity (increased risk in renal and hepatic impairment)
Note: requires light protections, use only clear solutions, blue color indicates degradation to cyanide

28
Q

Inotropes

A

They increase the contractility of the heart

29
Q

Dobutamine MOA

A

MOA: beta-1 agonist with some beta-2 and alpha-1 agonism. It increases HR and force of contraction which increases CO
(may turn slightly pink due to oxidation but potency is not lost)

30
Q

Milrinone MOA

A

Selective PDE-3 inhibitor in cardiac and vascular tissue. It produces inotropic effects with significant vasodilation

31
Q

Hypovolemic Shock

A

To treat fluid resuscitation with crystalloids is generally recommended as 1st line therapy for hypovolemic shock that is not caused by hemorrhage.
Vasopressors will not be effective unless intravascular volume is adequate

32
Q

Distributive Shock

A

Include septic, anaphylactic, and neurogenic shock

33
Q

Sepsis and Septic Shock

A

Sepsis is life-threatening organ dysfunction cause by a dysregulated host response to infection
Septic shock is sepsis in the presence of persistent hypotension requiring a vasopressor to maintain a MAP >=65
Early administration of broad-spectrum abx and crystalloids. Norepinephrine is the vasopressor of choice for septic shock.

34
Q

General Principles for treating Septic Shock

A

Target MAP of >= 65
MAP = [(2 x DBP)+SBP]/3
“fill the tank:” optimize preload with IV crystalloid fluids (prn)
“squeeze the pipe and kick the pump:” alpha-1 agonist activity (peripheral vasoconstriction) to increase systemic vascular resistance; beta-1 agonist activity to increase myocardial contractility and CO

35
Q

Two common causes of ICU infections

A
  • ventilation

- foley catheters

36
Q

Acute Decompensate and Cardiogenic Shock

A

Patients with HF may experience episodes of worsening symptoms (sudden weight gain, unable to perform daily routine), this is called acute decompensated HF (ADHF) and when hypoperfusion and hypotension are also present it is called cardiogenic shock

37
Q

ADHF Clinical presentation

A

BB should only be stopped in ADHF episode if hypotension or hypo-perfusion is present
ADHF presents with volume overload, hypo-perfusion or both

38
Q

ADHF Assessment

A

Sometimes invasive monitoring with a catheter that is guided through the right side of the heart into the pulmonary artery called a Swan-Ganz or Pulmonary Artery (PA) catheter.
This provides measurements of pulmonary apaillary wedge pressure, cardiac output

39
Q

ADHF tx

A

Patients with edema, JVD, and/or ascites are volume overloaded tx options include:

  • loop diuretics
  • vasodilators

Pts with decreased renal fx, altered mental status, and/or cool extremities have hypo-perfusion tx includes:

  • inotrope (dobutamine, milrinone)
  • if pt becomes hypotensive consider vasopressor
40
Q

Pain

A

Opioids given IV, such as morphine, hydromorphone, and fentanyl, are 1st line for analgesia
Analgesia based sedation or analgosedation is a sedation strategy that uses analgesia first to relieve pain and discomfort.

41
Q

Sedation

A

Sedation is necessary for some ICU patients to maintain synchronized breathing with the ventilator (prevent “bucking” the ventilator

42
Q

Agitation management

A

agitation is managed with benzodiazepine or non-benzos (propofol and dexmedetomidine) which are preferred and are associated with improved ICU outcomes
Dexmetomidine (precedex) is the only sedative approved for use in intubated and non-intubated patients

43
Q

Delirium

A

Sedation with non-benzos may reduce incidence of delirium and/or shorten duration in patients who already have it

44
Q

Dexmedetomide MOA, SE, notes

A

Precedex
MOA: Alpha-2 adrenergic agonist
SE: hypo/hypertension, bradycardia
Notes: does not require refrigeration, duration of infusion should not exceed 24 hours, used for sedation in intubated and non-intubated patients

45
Q

Propofol MOA, SE, notes

A

Diprivan
MOA: short-acting general anesthetic
SE: hyptension, apnea, hypertriglyceridemia, green urine/hair/nail beds, propofol-related infusion syndrome (PRIS) rate but fatal
Notes: oil in water emuslion (1.1kcal/ml)

46
Q

Lorazepam

A

Propylene glycol toxicity (acute renal failure and metabolic acidosis)

47
Q

Midazolam CI, Notes

A

Versed
CI: use with potent CYP3A4 inhibitors
Notes: Can accumulate in patients with renal impairment (active metabolite)

48
Q

Etomidate monitoring

A

Amidate

Monitoring: s/sx of adrenal insufficiency (hypotension, hyperkalemia)

49
Q

Ketamine warnings

A

Ketalar

Warnings: Emergence rxs (vivid dreams, hallucinations, delirium)

50
Q

Stress Ulcers Tx

A

H2RAs and PPIs for prophylaxis

PPIs have been associated with increased risk for GI infections (C.Diff), fractures, and nosocomial pneumonia

51
Q

Risk factors for development of stress ulcers

A
  • mechanical ventilation >48hrs
  • coagulopathy
  • sepsis
  • TBI
  • major burns
  • acute renal failure
  • high dose systemic steroids
52
Q

Local anesthetic

A

Lidocaine (xylocaine)

53
Q

Inhaled anesthetic

A

Desflurane (suprane), sevoflurane (ultane)

54
Q

Injectable anesthetic

A

Bupivicaine, ropivacaine

55
Q

Anesthetic warnings

A

Can cause malignant hypothermia (MH)

Bupivicaine, used in epidurals, can be fatal if administered IV

56
Q

Lido/epi

A

Epi keeps lido localized

57
Q

Neuromuscular blocking agents (NMBA)

A

Cause paralysis of the skeletal muscle, including those used for respiration.
Patients can require NMBA in surgery conducted under general anesthesia to facilitate mechanical ventilation, to treat muscle spasms (tetany).
NMBAs have to effect on pain so patients should receive adequate sedation and analgesia prior to starting an NMBA
Patients must be mechanically ventilated

58
Q

Types of NMBA

A

-Depolarizing and non-depolarizing

59
Q

Succinylcholine

A
  • Succinylcholine is the only available depolarizing agent and is reserved for intubation
  • Short acting, fast onset (30-60sec)
60
Q

Non-depolarizing NMBA SE

A

SE for all: flushing, bradycardia, hypotension, tachyphylaxis

  • Cisatracurium (nimbex): metabolized by Hoffman elimination (independent of renal and hepatic fx)
  • Pancuronium: long-acting
61
Q

Hemostatic agents MOA

A

Systemic hemostatic drugs work by inhibiting fibrinolysis or enhancing coagulation.

62
Q

Topical hemostatic agents

A

Recothrom, Thrombin-JMI

names often include -throm

63
Q

Tranexamc acid

A

hemostatic agent
Cyklokapron (injection)
Lysteda (oral) approved for use in heavy menstrual bleeding (menorrhagia)

64
Q

Recombinant Factor VIIa

A

NovoSeven RT

fda approved for hemophilia and factor VII deficinecy

65
Q

Intravenous Immunoglobulins Warnings, SE

A

Boxed warnings: acute renal dysfunction can occur, usually occurs within 7 days (more likely with products stabilized with sucrose), thrombosis
SE: HA, nausea, diarrhea, injection site rx, infusion rx (facial flushing, chest tightness, fever, chills, hypotension-slow/stop infusion

NAPLEX (45 decks)

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