Common pathologies of pregnancy 1-3 Flashcards
What does progesterone do to the endometrium? - detailed
endometrium –> decidua
between glands and vessels stromal cells enlarge and become procoagulant
Where are trophoblast cells found?
outside of fertilised egg
What hormone does trophoblasts produce?
bhCG
Actions of BhCG
target ovary - corpus luteum to produce progesterone to act on decidua
Trophoblasts action
stream off to invade maternal blood vessels and like these to fetal vessels - placenta
chorionic villi coated in trophoblasts cells
What cells prevent bleeding when trophoblast cells invade mother’s blood vessels?
decidual
Molar pregnancy
enlarged abnormal chorionic villi with abundant trophoblast
How do mum and dad switch off certain different genes in egg/sperm?
methylating them
What do mum and dads genes promote?
mum - early fetal growth
dad - early placental growth via trophoblast proliferation
What happens in a molar pregnancy?
2 sperm fertilise empty ovum
trophoblast overgrowth and placental overgrowth
Pre-cancer of molar pregnancy
can progress to malignant choriocarcinoma
Treating molar pregnancy
normal - no further treatment
still high - methotrexate
Difference between IUD and stillbirth
IUD - no fetal heart
still birth when born
Advantages of methadone
long half life
ora - avoid IV
