Cognitive Enhancers Quick Deck

Question 1

Enhances DA and NE release, activate prefrontal and limbic cortices (focus and maintenance of attention, low doses), activate cortex involved in motor activity (high/euphoric/toxic doses)

Answer 1

Psychostimulants –

Methylphenidate (Ritalin, Concerta) Amphetamine (Dexedrine, Adderall)

Question 2

Selective NE reuptake inhibitor, elevates DA levels in prefrontal

Answer 2

Atomoxetine

Straterra

Question 3

Inhibits AChE, stimulates nicotinic cholinergic neurons to release more ACh

Answer 3

Galanatamine

Razadyne

Question 4

Inhibits both AChE and BuChE

Answer 4

Rivastigmine

Exelon

Question 5

Inhibits AChE

Answer 5

Tacrine

Cognex

Question 6

NMDA R antagonist

Answer 6

Mermantine

Namenda

Question 7

DA: release in striatum and nucleus accumbens, may block DA reuptake
NE:release in hypothalamus
5HT: release in amygdala and frontal cortex
Elevates hypothalamic HA, activates glutaminergic circuits, inhibits GABAergic NTmission

Answer 7

Modafinil/Armodafinil