Antidepressants Quick Deck

Question 1

Block reuptake of NE and/or 5HT
Desipramine = NE-selective
Imipramine = NE and 5HT

Higher concentration of NT at their receptors

Answer 1

Tricyclic Antidepressants
Desipramine (Norpramin)
Imipramine (Tofranil)

Question 2

Irreversibly blocks MAO-A (NE and 5HT) and MAO-B (DA)

Increased NT in vesicles/released/action at R

Answer 2

Monoamine Oxidase Inhibitors

Phenelzine (Nardil)

Question 3

Blocks reuptake of 5HT from synapse (5HT2A R)  can trigger actions postsynaptically or bind to autoreceptors & inhibit more 5HT release

Answer 3

Selective Serotonin Reuptake Inhibitors
Fluoxetine (Prozac),
Sertraline (Zoloft), Escitalopram (Lexapro)

Question 4

SNRI – blocks 5HT + NE reuptake

Efficacy improves with increasing dose (increase dose: only 5HTalso NEalso DA)

Answer 4

Venlafaxine (Effexor)

Question 5

Blocks presynaptic α2 R on NE neurons (autoR) and 5HT neurons (heteroR)  increases NE and 5HT levels

Answer 5

Mirtazapine (Remeron)

Question 6

Injectable anesthetic, NMDA antagonist (glutamate)

Answer 6

Ketamine

Question 7

Effects postsynaptic neuron – alters gene expression implicated in long-term neuroplastic events  long-term mood stabilization

Answer 7

Lithium Carbonate

Lithobid, Eskalith