Anxolytics-Sedative-Hypnotics Quick Deck

Question 1

Bind to multiple isoforms of GABAA R, increases DURATION of GABA channel opening
A/D (lipid solubility) M (hepatic, slow) E (kidney, tx phenobarbital overdose by raising urinary pH)

Answer 1

Barbiturates:

Phenobarbital, Pentobarbital, Thiopental

Question 2

Bind to multiple isoforms of GABAA R, increases FREQUENCY of GABA channel opening (allosterically)
A/D (triazolam rapid, lipid solubility), M (hepatic, active metabolites), E (kidneys)

Answer 2

Benzodiazepines:

Diazepam, Lorazepam, Triazolam, Alprazolam

Question 3

Benzo binding site antagonist

Answer 3

Flumazenil

Question 4

Non-benzo benzo-R agonist, selectively bind certain subtypes of GABAA R

Answer 4

Zolpidem (Ambien)

Question 5

Partial agonist at 5HT1A R + affinity for D2 DA R (no interax with GABA)

Answer 5

Busipirone

Question 6

MT1 & MT2 melatonin R agonist at suprachiasmatic nuclei (no interax with GABA)

Answer 6

Ramelton (Rozerem)