Coeliac Disease Flashcards
What is it?
When does it usually present?
Autoimmune response to the complex made by gluten which causes intestinal damage
When you are children
S+S:
GI - 4
Why might you get fatigued?
Why might you get osteoporosis?
What may you find in and around the mouth? - 2
What is the skin presentation of coeliac?
Diarrhoea and steatorrhoea
Abdominal pain
Bloating
Weight loss
Anaemia
Calcium and vitamin D malabsorption
Mouth ulcers
Angular stomatitis
Dermatitis herpetiformis
S+S:
What symptoms may you find in infants and young children?
Diarrhoea and constipation
Failure to thrive
Vomiting and anorexia
Risk factors - 3
FH
Other autoimmune diseases
IgA deficiency
Investigations:
What is the main thing used to diagnose CD?
What confirms the diagnosis?
What antigen can also be used if the diagnosis is unclear?
What instruction should be given to the patient to make sure tests are accurate?
Anti-tTG IgA
Biopsy via upper endoscopy
HLA-DQ2/8 typing
Stay on gluten
Investigations - Bloods:
Why would you do:
- FBC and blood smear
- LFT
- Ca and albumin
- Skin biopsy
- How to check bones?
Anaemia - usually iron deficient
Raised transaminases
Usually poorly absorbed and may cause osteoporosis and oedema
Dermatitis herpetiformis
DEXA scan
Screening for Coeliac - in what 2 situations is it done?
1st-degree relatives of anyone with coeliac
Patients with autoimmune thyroid disease or T1 disease
Management:
Dietary
What else needs to be done which is very important?
Life-long gluten-free diet
Remove wheat (bread and pasta), rye and barley Plenty of hidden sources as well
Replace micronutrients if deficient - Ca, Vit D, Iron, Folate, B12
Management:
What should be done in the annual review?
What should be done every 3 years?
Check BMI
Review diet and symptoms
Consider bloods for deficiencies
DEXA scan
Complications - 2
Osteoporosis
Carcinoma or lymphoma
