ALF - Other Causes***** Flashcards

1
Q

Non-paracetamol drug induced ALF is a diagnosis of exclusion.

What hep virus is commonly misdiagnosed as a drug induced liver failure?

What drug used to treat TB? - R

What antibiotic used to Rx UTI’s could be cause?

What anti-epileptic drugs could be a cause?

Why are NSAID’s avoided?

A

Hep E

Rifampicin

Nitrofurantoin

Due to the increased hepatorenal syndrome

Valproate

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2
Q

Ischaemic injury:

What 2 recreational drugs can cause this?

A

Cocaine

MDMA

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3
Q

Viral hepatitis:

What 3 hep viruses are you concerned about?

Autoimmune hepatitis - what is needed for diagnosis?

A

Hep A, B and E

Autoantibodies and immunoglobulin testing

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4
Q

What is it called if you can’t find a reason for the ALF?

A

Indeterminante ALF

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5
Q

List some pregnancy related liver disease?

A

HG
Pre-eclampsia and eclampsia (due to hepatic rupture)
HELLP syndrome
Acute fatty liver of pregnancy

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6
Q

Miscellaneous cause of ALF:

Malignant infiltration of the liver can present as ALF.

What toxins can cause ALF? - 4

Budd-Chiari syndrome - what is it?

Wilson’s disease can also cause it. What is it?

A

Cocaine
Ecstasy - MDMA
Herbal remedies
Mushrooms

ALF with previous hepatic vein thrombosis

Inability for the liver to metabolise copper properly so there is a build up copper

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