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PHARMA > CNS Stimulants > Flashcards

CNS Stimulants Flashcards

0
Q

classification of CNS stimulants

A

medullary stimulants
cortical stimulants
convulsants

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1
Q

define CNS stimulants

A

used to counteract excess depression of CNS

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2
Q

medullary stimulants are also known as __________

A

analeptics

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3
Q

the drugs that stimulate repsiration mainly by direct stimulation of medullary respiratory centre are called as ________

A

analeptics

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4
Q

analeptics are also known as ___________

A

medullary stimulants

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5
Q

convulsants(3rd category of CNS stimulants) stimulate which part of body

A

spine

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6
Q

name 3 medullary stimulants(BuNDi)

A

beme-gride
niketh-amide
doxa-pram

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7
Q

niketh-amine is aka _______

A

cor-amine

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8
Q

which drug is more selective on respiratory centre than other analeptics/medullary stimulants

A

doxa-pram

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9
Q

name 3 cortical stimulants(CA2)

A

caffeine
amino-phylline
amphet-amine

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10
Q

caffine is an alkaloid derieved from ___________ & ____________

A

seeds of coffee(coffea arabica)

leaves of tea(thea sinensis)

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11
Q

scientific name of coffee

A

coffee arabica

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12
Q

scientific name of tea

A

thea sinensis

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13
Q

MOA of caffeine

A 
stimulate Res. centre(by increasing sensitivity to CO2)
stimulate myocardium(by increasing local cAMP level)
stimulate CNS(by blocking adenosine action in medulla)
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14
Q

how caffeine stimulate respiratory centre

A

by sensitizing respiratory centre to CNS

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15
Q

how caffeine stimulate heart

A

by stimulating myocardium by increasing local cAMP level/inhibition of phospho-diesterase

16
Q

how caffeine stimulate CNS

A

by blocking adenosine action on medulla

17
Q

which CNS stimulant is also an anoractic agent

A

amphet-amine

18
Q

which 2 CNS stimulants are also used as broncho-spasm relievers

A

amino-phylline

amphet-amine

19
Q

name the 3 convulsants(SP2)

A

stry-ch-nine
picro-toxin
pentylene-tetrazol

20
Q

stry-ch-nine is an alkaloid derieved from _____________

A

seeds of Stry-ch-nos nuxvomica

21
Q

MOA of action of stry-ch-nine

A

antagonism of post-synaptic inhibition mediated by GLYCINE in CNS

22
Q

_________ is a competitive antagonist of glycine in spinal cord

A

stry-ch-nine

23
Q

stry-ch-nine causes severe ______ convulsions

A

spinal

24
Q

picrotoxin is a _____________ substance in nature

A

non-nitrogenous

25
Q

picrotoxin is derieved from ________

A

seeds of Anamirta cocculus

26
Q

anamirta cocculus is also known as _________

A

fish berries

27
Q

MOA of picrotoxin

A

antagonism of pre-synaptic inhibition in CNS mediated by GABA

(same as pentylene-tetrazol)

28
Q

which convulsant antagonizes glycine

A

stry-ch-nine

29
Q

which convulsants antagonizes GABA

A

picrotoxin

pentylene-tetrazol

30
Q

MOA of picrotoxin is similar to _________

A

pentylene-tetrazol

PHARMA (10 decks)

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