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PHARMA > Antipsychotics > Flashcards

Antipsychotics Flashcards

0
Q

affective disorders aka

A

nervous disorders

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1
Q

define anti-psy-chotics

A

drugs used in psychological or affective disorders.

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2
Q

affective disorders are of two forms

A
  1. depression

2. mania

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3
Q

anti psychotics are of two types

A 
antidepressants(deal with depression)
antimaniac drugs(deal with mania)
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4
Q

antidepressants are also known as _________ or ________

A

thymo-leptics

mood elevators

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5
Q

pharmacologically depression is due to deficiency of ______ in _______ of brain

A

monoamines

limbic system

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6
Q

clasification of antidepressants(STM)

A
  1. seretonin(5HT) reuptake inhibitors
  2. tricyclic antidepressants
  3. monoamine oxidase(MAO) inhibitors
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7
Q

name 3 tricyclic depressants

A

imi-pramine
desi-pramine
doxe-pin

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8
Q

name 3 MAO inhibitors

A

moclo-bemide
iproni-azid
sele-giline

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9
Q

name 3 seretonin reuptake inhibitors

A

fluo-xetine
paro-xetine
serta-raline

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10
Q

MOA of tricyclic antidepressants

A

inhibit uptake of NER & 5HT by mono-aminergic nerve terminals

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11
Q

MOA of MAO inhibitors

A

inhibit both forms of MAO

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12
Q

MOA of seretonin reuptake inhibitor

A

inhibit uptake of 5HT by tryt-aminergic nerve terminals

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13
Q

MAO(a) is specific to ________ & _________

A

ER & NER

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14
Q

MAO(b) is specific to ________ & ________

A

5HT

dopamine

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15
Q

cheese,wine,chocolate contain ______ which is metabolised by _____ in liver

A

tyr-amine

MAO(a)

16
Q

what is the end action of tyramine after entering adrenergic nerves?

A

release NER from adrenergic nerve terminals

17
Q

tyramine is converted to ______ in adrenergic nerve terminal

A

octo-pamine

18
Q

hypericin is an inhibitor of _______

A

MAO

19
Q

what are the other functions of hypericin?

A

germicidal

anti-inflamatory

20
Q

hypericine is derieved from ________

A

hypericum perforatum

21
Q

hypericum perforatum is aka ________

A

saint john’s wort

22
Q

we derieve ________ from saint john’s wort

A

hypericin(an MAO inihibitor i.e. anti-depressant)

23
Q

mania means

A

over-confidence,hyperactivity

24
Q

pharmacologically mania is due to ________ overactivity in the _______ of brain

A

dopaminergic

limbic system

25
Q

antimaniac drugs are used to get rid of _______

A

mania

26
Q

anti-maniac drugs are aka

A

mood stabilizing drugs

27
Q

3 drugs fo treatment for mania

A

lithium carbonate
car-bamazepine
valproic acid

28
Q

lithium carbonate does not affect the 5HT release T/F

A

T

it only effects NER & dopamine

29
Q

name a MAO inhibitor which is germicidal and anti-inflamatory

A

hypericin

PHARMA (10 decks)

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