Antipsychotics Flashcards
affective disorders aka
nervous disorders
define anti-psy-chotics
drugs used in psychological or affective disorders.
affective disorders are of two forms
- depression
2. mania
anti psychotics are of two types
antidepressants(deal with depression) antimaniac drugs(deal with mania)
antidepressants are also known as _________ or ________
thymo-leptics
mood elevators
pharmacologically depression is due to deficiency of ______ in _______ of brain
monoamines
limbic system
clasification of antidepressants(STM)
- seretonin(5HT) reuptake inhibitors
- tricyclic antidepressants
- monoamine oxidase(MAO) inhibitors
name 3 tricyclic depressants
imi-pramine
desi-pramine
doxe-pin
name 3 MAO inhibitors
moclo-bemide
iproni-azid
sele-giline
name 3 seretonin reuptake inhibitors
fluo-xetine
paro-xetine
serta-raline
MOA of tricyclic antidepressants
inhibit uptake of NER & 5HT by mono-aminergic nerve terminals
MOA of MAO inhibitors
inhibit both forms of MAO
MOA of seretonin reuptake inhibitor
inhibit uptake of 5HT by tryt-aminergic nerve terminals
MAO(a) is specific to ________ & _________
ER & NER
MAO(b) is specific to ________ & ________
5HT
dopamine
cheese,wine,chocolate contain ______ which is metabolised by _____ in liver
tyr-amine
MAO(a)
what is the end action of tyramine after entering adrenergic nerves?
release NER from adrenergic nerve terminals
tyramine is converted to ______ in adrenergic nerve terminal
octo-pamine
hypericin is an inhibitor of _______
MAO
what are the other functions of hypericin?
germicidal
anti-inflamatory
hypericine is derieved from ________
hypericum perforatum
hypericum perforatum is aka ________
saint john’s wort
we derieve ________ from saint john’s wort
hypericin(an MAO inihibitor i.e. anti-depressant)
mania means
over-confidence,hyperactivity
pharmacologically mania is due to ________ overactivity in the _______ of brain
dopaminergic
limbic system
antimaniac drugs are used to get rid of _______
mania
anti-maniac drugs are aka
mood stabilizing drugs
3 drugs fo treatment for mania
lithium carbonate
car-bamazepine
valproic acid
lithium carbonate does not affect the 5HT release T/F
T
it only effects NER & dopamine
name a MAO inhibitor which is germicidal and anti-inflamatory
hypericin
