CNS

Question 1

“Brain Metastasis” refers to metastatic
lesion involving the ___ ___

Answer 1

brain parenchyma

Question 2

CNS cancer mean age

Answer 2

55-65 years

Question 3

MRI with ___ to diagonse CNS cancer

Answer 3

Gadolinium

Question 4

When diagnosing CNS cancer and MRI is unavaliable use a __

Answer 4

CT with contrast

Question 5

Brain ___ are the most common type of brain
tumor

Answer 5

metastases

Question 6

With CNS cancer what are the most common places for it to spread in order from greatest

Answer 6

Lung
Breast
Melanoma (skin)
colorectal (rectum)

Question 7

Whole Brain Radiation Therapy (WBRT):
Fractionated treatment typically given
over ___ time course

Answer 7

2-3 week

Question 8

What radiation treatment type is used to treat CNS

Answer 8

SRS

Question 9

When is protons used instead of photons in CNS cancers

Answer 9

When less rad is needed based on location. (Base of skull or optic nerve)

Question 10

Radiaiton acute side effects of CNS cancer happen in the first few ___

Answer 10

Weeks

Question 11

Radiaiton acute side effects of CNS cancer include (8)

Answer 11

Drowsiness
nausea
vomiting
headache
alopecia
skin reaction
hearing loss
transient/worsening focal deficits

Question 12

Subacute reactions occure (time)

Answer 12

1 to 6 months post RT

Question 13

Subacute is caused by

Answer 13

diffuse demyelination

Question 14

Subacute symptoms include (3)

Answer 14

Headache,
fatigue,
somnolence

Question 15

Late reactions occure (time)

Answer 15

6 months or longer post RT

Question 16

Late reactions are caused by (3)

Answer 16

White matter damage,
Demyelination
Necrosis

Question 17

General Side Effects of RTT to CNS (9)

Answer 17

1. FATIGUE!!!
2. Complete hair loss (WBRT)
3. partial hair loss
   (SRT)(sometimes permanent)
4. Stuffy ears” (WBRT)
5. Headaches
6. Nausea/vomiting
7. Vision changes
8. Short term memory loss
9. Radiation necrosis occurs at 6000cGy

Question 18

Frontal lobe functions (8)

Answer 18

Executive functions
thinking
organising
emotions
behavioral control
problem solving
planning
personality

Question 19

Motor cortex function

Answer 19

Movement

Question 20

Sensory cortex funtion

Answer 20

Sensations

Question 21

Parietal lobe function (3)

Answer 21

Perception
Making sence of world
arithemic spelling

Question 22

Temporal lobe function (3)

Answer 22

Memory
Understanding
Language

Question 23

Occipital lobe function

Answer 23

Vision

Question 24

Grade IV astrocytoma characteristics (4)

Answer 24

Highly infiltrative
Rapidly Growing
Areas of necrosis
Rapidly invades nearby tissues

Question 25

How do you treat Grade IV astrocytoma with radiation

Answer 25

IMRT radiation x 30 fractions with
concurrent oral Temodar

Question 26

Where does Medulloblastoma originate

Answer 26

cerebellum

Question 27

Medulloblastoma Occurs in ___ more often
than ___.

Answer 27

Children
Adults

Question 28

Medulloblastoma is a Fast-growing ___ but
sensitive to ___

Answer 28

Tumor
Radiation

Question 29

Medulloblastoma can ___ in spinal fluid, leading to a ___ prognosis

Answer 29

Seed
Worse

Question 30

Chemo can be ineffective for CNS beacuse of the ___ ___ ___

Answer 30

Blood Brain Barrier