Clotty boi Flashcards
Vitamin K dependant clotting factors
II, VII, IX and X.
Treatment for vitamin K deficiency
phytomenadoine
What is Haemophilia A and how is it inherited?
X-linked recessive, lack of factor VIII
classes of haemophilia A
Three classes less than 1, 1-5 and 5+ (Levels of VII). Very severe disease, bleed into joints
APTT and PT in haemophilia A
APTT increased, PT normal.
Treatment for haemophilia A
Give factor VII
What is haemophilia B
Lack of Factor IX, x-linked recessive
Types of vW’s disease
Type one and 2 are mild forms, autosomal dominant. Type 3 is worse and recessively inherited
Investigation findings in VW’s (APPT and PT)
Prolonged APTT, normal PT and decreased levels of VII and vWF
Antiplatelets for arterial or venous clotting?
Arterial thrombosis
What does heprin do in the clotting cascade?
Increase the effect of anti thrombin
Which takes longer to work, wafarin or heparin?
Warfarin, so heparin is started first to overlap
Mechanism of fondaparinux?
Inhibits factor x, similar to LWMH
What is bivalirudin used in?
PCI
What is used in patients with heparin-induced thrombocytoponia?
Lepirudin
What type of drugs are ticagrelor and clopidogrel?
Antiplatelet
Name a LWMH
Enoxaparin
Anticoagulation for most cardiac things
Warfarin
Warfarin and pregnancy
Do not use. Can use in breast feeding
Thrombin inhibitor
dabigatran
factor Xa inhibitors
rivaoxaban, apixaban, edoxaban
What dissolves the fibrin clot physiologically?
plasminogen/plasmin
If 50/50 clotting test corrects
Somethings was deficient in the patients blood
If 50/50 clotting test doesn’t correct
There is an inhibitor in the patients blood
