Clostridium difficile Flashcards
where do we find clostridium difficile in the hospital?
everywhere there are flowers
how does clos. difficile transmit?
by ingestoin of the spores and not washing our hands when going to the bathroom
where will clos. difficile colonize in the normal individual?
Gut
disease caused by clos. difficile is also called?
Antibiotic-associated GI tract disease *
what diseases will clos. difficile cause?
diarrhea
Pseodomembranous colitis *
what is the key factor or essential history that will lead to clos. difficile complications?
Antibiotic therapy key factor that alters colonic flora*
what patients are most prone to acquiring clos. difficile?
hospitalized patients and nursing homes receiving antibiotic therapy
what toxins does c. difficile have?
entero toxin A
cyto toxin B
what will cause the diarrhea in c. difficile?
entero toxin A
what will cause the cell death or damage in c. difficile?
Cyto Toxin b
what is the worst disease c. difficile cause?
pseudomembranous colitis
if there is damage to the cells with cyto toxin B, what will we find in the diarrhea?
RBC’s
what will be seen in pseudomembranous colitis?
yellowish patches on the mucosa
what antibiotic will induce c. difficile?
clindamycin
what other antibiotic, besides clindamycin, will lead to pseudomembranous colitis?
cephalosporins
