antibiotics: uncosamides Flashcards
1
Q
how does uncosamides work?
A
block peptide transfer at 50s ribosomal subunit
2
Q
what is an example of uncosamides?
A
clindamyicin
3
Q
against what is clindamyicin used against?
A
pneumocystic carnii and toxoplasma gandil
4
Q
what are uncosamides used against?
A
anaerobic bacteria
gn anaerobe
gp anaerobe
5
Q
what mechanism of resistance do bacteria use for uncosamides?
A
methylation of binding site on 50s subunit
6
Q
when can uncosamides by used?
A
for prophylaxis of infectious endocarditis
7
Q
what are some side effects of clindamyicin?
A
superinfection by pseudomembranous colitis
overgrowth of C.Difficele
8
Q
how do you treat a superinfection with pseudomembranous colitis?
A
treat with vancomycin/metrodinzaole
9
Q
A
