Clinical Significance of Lipase (Reporting | M)

Question 1

What is the difference of LPS bet AMS?

Answer 1

LPS is highly sensitive and sp > AMS

Question 2

What are the fxns of LPS?

Answer 2

1) It is used to diagnose acute pancreatitis

2) It works together w/ bile (whereas it fxns in the digestion of fat)

Question 3

In connection to the fxn of LPS, what happens if LPS lvls in the pt is not enough?

Answer 3

The pt’s body will have trouble absorbing fat and important soluble vitamins

Question 4

What are the important soluble vitamins that the pt’s body will have trouble absorbing if the pt’s LPS lvls are not enough?

Answer 4

Vitamins:

1) A
2) D
3) E
4) K

Question 5

What is the characteristic of acute pancreatitis?

Answer 5

It is sometimes difficult to be diagnosed

Question 6

What is the result if the pt’s LPS lvls are not enough?

Answer 6

The pt will exp poor fat absorption (including diarrhea) and fatty bowel movements

Question 7

Why is acute pancreatitis sometimes difficult to be diagnosed?

Answer 7

Because it is needed to be diagnosed properly in separation to acute intra-abdominal disorders w/ similar clinical findings w/ acute pancreatitis

Question 8

What are the acute intra-abdominal disorders / conditions that are clinically similar w/ acute pancreatitis?

Answer 8

1) Perforated gastric or duodenal ulcer
2) Intestinal obstruction
3) Mesenteric vascular obstruction

Question 9

If AMS and LPS lvls are both elevated, what is the difference between the 2?

Answer 9

LPS is elevated longer > AMS

Question 10

Since LPS is elevated longer > AMS, where can LPS be used?

Answer 10

LPS is recommended for use in emergency cases

Question 11

What are the conditions / disorders that cause increased lipase?

Answer 11

1) Hyperlipasemia
2) Pancreatitis
3) Peptic ulcer
4) Cholecystitis

Question 12

What are conditions / disorders related to hyperlipasemia?

Answer 12

1) Increased multiple-organ dysfunction sores
2) Hypotension
3) Anemia
4) Mechanical ventilation (MV)
5) Bacteremia
6) Elevated LFT results
7) Elevated crea and TAG lvls

Question 13

What is pancreatitis?

Answer 13

It is the condition of redness and swelling (inflammation) of the pancreas

Question 14

What is the characteristic of pancreatitis?

Answer 14

It may be sudden (acute) or ongoing (chronic)

Question 15

What are the most common causes of pancreatitis?

Answer 15

1) Alcohol abuse

2) Lumps of solid material (gallstones) present in the gallbladder

Question 16

What are the characteristics present in chronic pancreatitis?

Answer 16

1) Gallstones and calcifications present in the dilated pancreatic duct
2) Presence of inflamed pancreas

Question 17

What are the characteristics of acute pancreatitis?

Answer 17

1) Presence of gallstones blocking the pancreatic duct

2) Presence of inflamed pancreas

Question 18

What is peptic ulcer?

Answer 18

It is an open sore in the stomach lining or the upper part of the small intestine (duodenum)

Question 19

What are the characteristics of peptic ulcer?

Answer 19

An ulcer can go through all the layers of the digestive tract and form a hole (perforation)

Question 20

If an ulcer forms a hole in the digestive tract, what is it called?

Answer 20

Perforated ulcer

Question 21

What is cholecystitis?

Answer 21

It the redness and swelling (inflammation) of the gallbladder

Question 22

When and how does cholecystitis occur?

Answer 22

It happens when a digestive juice called bile gets trapped in the gallbladder

Question 23

What are the conditions / disorders that causes decreased lipase?

Answer 23

1) Cystic fibrosis
2) Sx storage
3) Hemolyzed sxs

Question 24

How can cystic fibrosis cause decreased LPS lvls?

Answer 24

Damage to the cells of the pancreas w/c make LPS is present, hence, resulting to decreased LPS lvls

Question 25

If the sx for determination of LPS lvls is present in room temp, the LPS looses its activity at what time duration?

Answer 25

1 wk

Question 26

If the sx for determination of LPS lvls is present in ref temp, the LPS looses its activity at what time duration?

Answer 26

3 wks

Question 27

Why is hemolyzed sxs should be avoided in terms of determination of LPS lvls?

Answer 27

Because the hgb present inhibits the activity of serum LPS

Question 28

What is the result of the action of hgb where it inhibits the activity of serum LPS?

Answer 28

It will result to falsely low values of LPS

Question 29

What is the sx used for determination of LPS lvls?

Answer 29

Serum

Question 30

What is the other sx used for determination of LPS lvls?

Answer 30

Urine

Question 31

What are the other conditions / disorders that causes decreased LPS lvls?

Answer 31

1) Cancer radiotherapy and/or chemotherapy to assess pt’s gastric cancer
2) Diabetes (type 1 and 2)
3) Pancreatic cancer

Question 32

If a pt has pancreatic cancer, why is the pt’s LPS lvls decreased?

Answer 32

Because the production of LPS is affected due to organ failure

Question 33

What is the normal reference range for LPS?

Answer 33

< 38 U/L (37 DC)

Question 34

Is there a pt preparation that should be followed by the pt prior to determination of LPS lvls? If yes, what is it?

Answer 34

Yes, the pt should do fasting

Question 35

Why should the pt fast prior to determination of LPS lvs?

Answer 35

Due to the tissue sources of LPS whereas stomach and small intestine are included, hence, if the pt ate prior to the testing, the pt’s LPS lvls will falsely increase