Chp 1-3 Book Flashcards
an imaging tech created from sonor technology
ultrasound
microscopic examination of a frozen tissue specimen is an application of ….
histology
what is a cell
the basic structural and functional units of all living orgnisms
the changes an organism undergoes through time
development
in a negetive feedback mechanism, the response of the effector
is to make the deviation from the set point smaller
what is one of the structures contained in the mediastinum
esophagus
the plane that cuts the body lengthwise and seperates the body into anterior and posterior portions
frontal
What is anatomy?
scientific discipline that investigates the bodys structure (shape/size)
What is physiology?
scientific investigation of the processes or function of living things
What are the four topics of anatomy?
regional- area by area
systemic- system by system
surface- external form and relation to deeper structures as Xray in anatomic imaging
cytology- the study of cell
histology- tissues
what are the three topics of physiology?
cell- processes in cells
neurophysiology- nervous system
cardiovascular- heart and blood vessels
anatomical imaging
radiography, ultrasound, mri to create picture of internal structures. allows amazing accuracy without trauma.
What are two subjects that encompass both anatomy and physiology?
pathology
exercise physiology
pathology
structural and functional changes caused by disease
exercise physiology
changes in structure and function caused by disease
what are the six levels of organization?
chemical- atoms/molecules
cell- functional unit of life
tissue- similar cells
organ- several tissues
organ system- several organs
organism- a living thing
What are the organ systems of the body?
integumentary, skeletal, muscular, nervous, endocrine, cardiovascular, lymphatic, respiratory, digestive, urinary, reproductive
What are the 6 characteristics of human organism?
organization- specific relationships and functions
metabolism- chemical reactions of body
responsiveness- ability to sense changes
growth- increase in size and number of cells
development- changes in organism over time
reproduction- new cells or new organism
What are the two types of development?
differentiation- change from general to specific
morphogenesis- change in shape of tissues, organs.
What is homeostasis?
the existence and maintenance of a relatively constant environment within the body
set point
the ideal normal value of a variable
what are the two types of feedback system?
negative and positive
what are the three components of a feedback system?
receptor - monitors the value of some variable
control center - establishes set point
effector - change the value of the variable in response
What is negative feedback?
any deviation from the set point is made smaller
what is positive feedback?
when a deviation occurs, the response is to make the deviation greater
what is one example that positive feedback is good?
childbirth
What is the anatomical position?
body erect, face forward, feet together, palms face forward.
What is supine?
laying face up
What is prone?
lying face down
superior vs. inferior
toward the head and away from the head.
medial vs. lateral
toward the midline or away from
proximal vs distal
closer to point of attachment or farther away
superficial vs. deep
relative to the surface of the body
anterior vs posterior
forward and toward the back
What are the abdominal subdivisions
epigastic, hypochodriac, umbilical, lumbar, hypogastric, iliac
What are the four body planes
median
frontal or coronal
transverse
oblique
What are the three serous membranes?
pericardium- heart
pleura- lungs
peritoneum- abdominopelvic
What are the six kinds of imaging techniques?
radiography- xray
ultrasound - US
computed tomography- CT
digital subtraction angiography- DSA
magnetic resonance imaging- MRI
positron emission tomography- PET
radiography
shadowy negative of internal body structures
ultrasound
computer analyzed sound waves bounced off a structure
CT scan
computer analyzed composite of radiograph; shows slices of body
DSA
comparision of radiographs with and without dye
MRI
uses magnetism and radio waves to look for varying alignments of protons in soft tissues.
PET
uses radioactively labeled glucose- calculates metabolic activity of cells.
What is an element?
simplest type of matter with unique chemical properties
What is an atom?
smallest particle of an element that has chemical characteristic of that element
neutron
no charge
proton
positive charge
electron
negatively charged particle
Chemical bonds
when an electron is transferred or shared.
ionic bond
when an electron is lost or shared
covalent bond
when electron is shared
What is a molecule?
two or more atoms combine
What is a compound?
two or more atoms combine (different atoms)
What is a catalyst?
a substance that increases a chemical reaction without being depleted.
What is an enzyme?
a protein catalyst.
What is inorganic chemistry?
deals with substances that do not contain carbon.
What is a solution?
any mixture of liquid, gas, or solid.
What is an acid?
a proton donor - Ph less than 7
What is a base?
a proton acceptor
What is organic chemistry?
study of carbon containing substances
What are the four major groups needed for living things
carbohydrates
lipids
proteins
nucleic acid
What is the basic structure of the cell?
plasma membrane
cytoplasm
nucleus
plasma membrane
cell membrane, forms outer bondary of the cell
cytoplasm
between the two - contains organelles, jelly substance
nucleus
directs cell activity
organelles
specilized structures that perform specific functions
What are the 4 functions of the cell
- cell metabolism and energy use
- synthesis of molecules
- communication
- reproduction and inheritence
How is DNA exchanged?
gametes cells exchange DNA during sexual intercourse
What does the plasma membrane do?
separate inter-cellular from extracellular.
What is membrane potential?
a charge across the membrane from intracellular and extracellular ion concentrations.
What are the two types of glycocalyx
glycolipids - carbs +lipids
glycoproteins - carbs +proteins
What makes up the membrane lipids
phospholipids and cholesterol
What are the two types of membrane proteins
integral or intrinsic- extend deeply into membrane
peripheral or extrinsic- attached to integral proteins at either the inner or outer surfaces of lipid bilayer
What does membrane functioning depend on?
3D shape and chemical characteristics
Do membrane proteins matter?
marker molecules
attachment proteins
transport proteins
enzymes
receptor proteins
What are marker proteins
glycoproteins and glycolipids
cells identify each other.
What are the two types of attachment proteins
cadherins - cells to cells
integrins - integral proteins that attach to extracellular molecule.
What are the three types of transport proteins?
channel
carrier
ATP powered
What are the two types of Channel proteins?
nongated ion channels -always open. plasma membrane permeable to a few ions when the plasma membrane is at rest.
gated - opened/closed by stimuli
What are the two types of gated ion channels
ligand - opens - a small molecule binds to proteins or glycoproteins
voltage - opens - a change in charge across plasma membrane
What are the several forms of carrier proteins
uniporter- moves one particle
symporters- moves two particles in same direction at same time
antiporters - move two particles opposite directions at same time.
ATP powered transport depends on
concentration of substrate and ATP
What do the enzymes in the plasma membrane act to
catalyze reactions at outer/inner surface of plasma membrane.
What are the two types of receptor proteins
Receptors- linked to Channel Proteins
Receptors- linked to G protein complexes
Kinds of passive membrane transport
diffusion
osmosis
facilitated diffusion
kinds of active membrane transport
active transport
secondary active transport
vesicular transport
What is diffusion
movement of solutes in solution. higher concentration to lower concentration
What are the three parts of diffusion
concentration - difference between two points
viscosity - how easily liquid flows
temperature - affects the movement of particles.
What is osmosis?
diffusion of water across a selectively permeable membrane. water from area of low concentration to area of high concentration.
What is osmotic pressure?
force required to prevent water from moving across a membrane by osmosis
isomotic
solutions with same concentration of solute particles.
What is hyperosmotic
solution with a greater concentration of solute.
What is hyposmotic
solution with a lesser concentration of solute.
isotonic solution
cell neither shrinks nor swells
hypertonic solution
cell shrinks -crenation
hypotonic solution
cell swells -lysis
What does facilitated diffusion do?
move large, water soluble molecules or electrically charged molecules across membrane.
What does active transport depend on?
concentration of substrate and ATP
What is secondary active transport?
ions or molecules move in same or different direction.
What is endocytosis
internalization of substances - formation of vesicle.
What are the types of endocytosis
phagocytosis
pinocytosis
receptor mediated endocytosis
What is exocytosis
secretions expelled from the cell
What are the four parts of the cytoplasm
cytosol
cytoskeleton
cytoplasmic inclusions
organelles
What are the three parts of the cytoskeleton
microtubules
intermediate filaments
actin filaments
What is the cytosol
fluid portion of the cytoplasm
What does the cytoskeleton do
supports the cell
What are microtubules
hollow, internal scaffold, transport in cell, cell division.
What are cytoplasmic inclusions
aggregates of chemicals
What are organelles
small specilized structures- with specific structure/function.
What is part of chromosome structure
DNA + proteins
What are the two types of ribosomes
free and attached.
What are the two types of endoplasmic reticulum
rough - attached - proteins produced and modified
smooth - not attached - lipids and carbohydrates
What is the purpose of the gogli apparatus
modifications, packaging, distribution of proteisn and lipids
What are the two membranes on the mitochondria
cristae
matrix
Where are microtubules made
centrosome
Whats cilia
appendages projecting from cell surfaces
Whats microvilli
extension of plasma membrane
What is a gene
functional unit of heredity
What are the two types of genes
structural- serve as template fro mRNA
regulatory- control which structural genes transcribes in given tissue
What is transcription
DNA used to form mRNA
What is translation
synthesis of a protein at the ribosomes using mRNA< tRNA and rRNA.
What four things happen in transcription
DNA strands are seperated
RNA polymerase binds at promoter region
RNA polymerase helps form mRNA chain using DNA
transcription ends at terminator sequence
What does mRNA do?
directs polypeptide production.
Where does translation occur
ribosomes in cytoplasm
What is an interphase
phase between cell divisions
What are the four phases of cell division
prophase
metaphase
anaphase
telophase
What happens in metaphase
chromosomes are aligned at nuclear equator
What happens in anaphase
spindle fibers seperate the chromatids
What happens in telophase
chromosomes decondense
What happens in prophase
nuclear envelope disintegrates
What is cyrokinesis
cytoplasmic division.
What are the two steps in replication of DNA
DNA strands seperate
old strands become templates for new strands to form.
Human anatomy and physiology is the basis for what?
understanding disease
What does the word anatomy mean?
to dissect or cut apart and separate the parts of the body for study.
What does developmental anatomy study
the structural changes that occur between conception and adulthood.
What is embryology
a subspecialty of developmental anatomy, considers changes from conception to the end of the eight week of development.
What is cytology
examines the structural features of cells
What is histology
examines tissues, which are composed of cells and the materials surronding them
What is gross anatomy
the study of structures that can be examined without the aid of microscope, can be approached either systemically or regionally.
What is a system
a group of structures that have one or more common functions, such as cardiovascular, nervous, respiratory, skeletal, or muscular systems.
What is surface anatomy
involves looking at the exterior of the body to visualize structures deeper inside the body.
What are anatomical anomalies?
physical characteristics that differ from the normal pattern.
What is celWhat are the two types of systemic physiologyl physiology
examines the processes occuring in cells such as energy production from food
What is systemic physiology
considers the functions of organ systems.
What are the two types of systemic physiology
cardiovascular
neurophysiology
What is pathology
is the medical science dealing with all aspects of disease, with an emphasis on the cause and development of abnormal conditions, as well as the structural and functional changes resulting in disease.
What is exercise physiology?
focuses on the changes in function and structure caused by exercise.
What are the six levels of organization
chemical, cell, tissue, organ, organ system, organism
What does the chemical level involve
how atoms, interact and combine into molecules.
What does molecules structure determine
its function
What are cells
are the basic structural and functional units of all living organisms.
What do organelles do?
carry out particular functions, such as digestion and movement, for the cell.
What is human health dependent upon?
the health of our microbiota, the good bacteria.
What is a tissue
is composed of a group of similar cells and the materials surrounding them.
What are the 4 types of tissues?
epithelial, connective, muscle, nervous.
What is an organ
is composed of two or more tissue types that perform one or more common functions.
What determines the function of a tissue?
the characteristics of the cells and surrounding materials.
What are the major goals when studying human physiology
to understand and predict the body responses to stimuli and to understand how the body maintains conditions within a narrow range of values in a constantly changing environment.
What is an organ system
A group of organs working together to perform a particular function
What are the 11 major organ system?
integumentary, skeletal, muscular, nervous, endocrine, cardiovascular, lymphatic, respiratory, digestive, urinary, reproductive.
What is an organism
is any living thing considered as a whole- whether composed of one cell, or trillions of cells
organization
refers to the specific interrelationships among the parts of an organism and how those parts interact to perform specific functions.
What is metabolism
is the ability to use energy and to perform vital functions.
The shape of a molecule determines its what
function
What is metabolism necessary for?
vital functions like responsiveness, growth, development, and reproduction.
What is responsiveness
an organism ability to sense changes in its external or internal environment and adjust to those changes.
What does growth refer to?
an increase in the size or number of cells, which produces an overall enlargement of all or parts of an organism.
What is development
the changes an organism undergoes through time, beginning with fertilization and ending at death.
differentiation
involves changes in a cells structure and function from an immature, generalized state to a mature, specialized state.
What is morphogenesis
is the change in shape of tissues, organs, and the entire organism.
What is reproduction
the formation of new cells or new organism.
What are the six characteristics of life
organization
metabolism
responsiveness
growth
development
reproduction
homeostasis
the existence and maintenance of a relatively constant environment within the body
What must a body do to acheive homeostasis
the body must activly regulate conditions that are constantly changing
What must happen for a cell to function normally?
the volume, temp, and chemical content of their environment must be maintained within a narrow range.
What is one of the most well known examples of homeostasis
body temperature
What is negative feedback
when any deviation from the set point is made smaller or is resisted.
What are the three components of a negative feedback system
receptor, control center, effector.
What is a receptor
monitors the value of a variable such as body temp by detecting stimuli
What is the control center
determines the set point for the variable and receives input from the receptor about the variable
What is an effector
can adjust the value of the variable when directed y the control center, usually back towards the set point.
What is Orthostatic hypotension
is a significant drop in blood pressure upon standing
What are metabolic pathways
are chemical reactions driven by biological protein catalysts called enzymes.
What is positive feedback
occurs when a response to the original stimulus results in the deviation from the set point becoming even greater.
What is an examples of a normal positive feedback
birth, blood clots
What are the two basic principles about homeostatic mechanisms
many disease states result from the failure of negative feedback to maintain homeostasis.
some positive feedback mechanism can be detrimental instead of helpful.
What is one example of a detrimental positive feedback mechanism
inadequate delivery of blood to cardiac muscle
What is the anatomical position
refers to a person standing erect with the face directed forward, the upper limbs hanging to the sides, and the palms of the hands facing forward.
What does the sufix itis mean
inflammation
what does anterior mean
in front of
What does posterior mean
behind
What does ventral mean
towards the belly
What does dorsal mean
toward the back
proximal
closer to point of attachment
What does distal mean
farther from point of attachment
What does lateral mean
away from midline
What does medial mean
toward the midline
What is the term superior exchanged with
cephalic
What is the term inferior exchanged with
caudal
What does the central region of the body consist of
the head, neck, and trunk
What regions can the trunk be divided into
thorax, abdomen, pelvis.
What are the nine regions of the abdomen
epigastric, hypochindriac, umbilical, lumbar, hypogastric, iliac.
Saggital plane
seperates the body into right and left halves.
Median plane
saggital plane that passes through the midline of the body, dividing into equal halves.
Transverse plane
runs parrallel to the ground, dividing the body into superior and inferior portions.
Frontal plane
divides the body tino front and back halves.
What are the two types of internal cavities
dorsal and ventral body cavities.
What does the dorsal cavity enclose?
the organs of the nervous system, brain, and spinal cord.
What are the two subdivisions of the dorsal body cavity
cranial and vertebral
What are the two divisions of the ventral body cavity
thoracic cavity, abdominopelvic.
What can the thoraicic cavity be divided into
pleural cavaties, medial mediastinum
What is the parietal serous membrane
the layer that lines the walls of the cavity
What is the visceral serous membrane
the layer covering the internal organs.
What is the pleural cavity
contains the lungs
What is the peritoneal cavity
houses liver, digestive organs, and reproductive.
What are mesenteries
regions of double folded visceral peritoneum.
What do mesenteries provide
a pathway fro nerves and blood vessels to reach the digestive organs.
What does retroperitoneal mean
behind the peritoneum.
What is pericarditis
an inflammation of the serous pericardium.
What is cardiac tamponade
is a potentially fatal condition in which a large volume of fluid or blood accumulates in the pericardial cavity and compresses the heart from the outside.
What are some causes of cardiac tamponade
rupture of the heart wall, rupture of blood vessels in pericardium, damage to pericardium due to radiation therapy, and trauma.
What is pleurisy
inflammation of the pleura
What is peritonitis
inflammation of the peritoneum
What does chemicals compose?
the structures of the body and the interactions of chemicals with one another are responsible for the body’s functions.
What is chemistry
the scientific discipline concerned with the atomic composition of substances and the reactions they undergo.
What is matter
anything that occupies space
What is mass
the amount of matter in an object.
What is weight
the gravitational force acting on an object of a given force.
What is the international unit for mass
kilogram
What is an element
the simpliest type of matter, having unique chemical properties.
What is an atom
the smallest particle of an element that has chemical characteristics of that element. .
What is an element composed of
atoms of only one kind.
What does the characteristics of matter result from
the structure, organization, behavior of atoms
What is an electron cloud
the region where electrons are most likely to be found
How is each element uniquely defined
by the number of protons in the atoms of that element.
What is atomic number
an element that is equal to the number of protons in each atom and because the number of electrons is equal to the number of protons, the atomic number is also the number of electrons.
What is the mass number
the number of protons plus the number of neutrons in each atom.
What is an isotope
are two or more forms of the same element that have the same number of protons and electrons but a different number of nuetrons.
What is a dalton
unified atomic mass unit. a carbon mass with 6 protons and 6 neutrons.
What is atomic mass
is the average mass of its naturally occurring isotopes, taking into account the relative abundance of each isotope.
What is molar mass
the mass of 1 mole of a substance expressed in grams.
What is the chemical behavior of an atom dependent on
its electrons
What is electron shells
the energy levels are often depicted as concentric rings.
What is a valence shell
the outermost shell
What determines an atoms chemical nature
the number of electrons in the valence shell
What does inert mean
if the valence shell is full
What does chemically reactive mean
if an atoms valence shell is not full
What is the octet rule
the tendency of atoms to combine with other atoms until each has 8 electrons.
What are the two ways atoms achieve an octet
the transfer of electrons between atoms
the sharing of electrons between atoms
What is electronegativity
the ability of an atoms nucleus to attract electrons.
What are the two major types of chemical bonds
ionic and covalent.
What is an ion
when the numbers of protons and electrons are no longer equal, and called a charged particle.
What are cations
positively charged ions
When does an ionic bond form
when electrons are transferred between atoms, creating oppositely charged ions.
What is significance of calcium
functins in blood clotting, muscle contraction
What is sig of sodium
membrane potentials, water balance
what is sig of potassium
membrane potentials
What is sig of phosphate
parts of bone and teeth. functions in energy exchange, acid-base soltuion
what is sig of iron
red blood cell formation
what is sig of magnesium
necessary fro enzymes
what is sig of iodide
present in thyroid hormones.
When does a covalent bond form
when atoms share one or more pairs of electrons.
When does the sharing of electrons occur
when the atoms have similar electronegativities.
What is a single covalent bond
the sharing of one pair of electrons by two atoms
What is a double covalent bond
when two atoms share 4 electrons, 2 from each atom
What is nonpolar covalent bonds
when electrons are shared equally between atoms
What is polar covalent bonds
where the two atoms involved in a covalent bond have different electronegativities.
What is a molecule
is composed of two or more atoms chemically combined to form a structure that behaves as a independent unit.
What does a molecule normally consist of
consists of two or more different types of atoms
What is a compound
a substance resulting from the chemical combination of two or more different types of atoms.
What is a chemical formula
the formulas shows the kind of number of atoms present
What is an electron dot formula
the bonding electrons are shown as dots between the symbols of the atoms
What is bond line formula
the bonding electrons are shown as lines between teh symbols of the atoms
What is models
atoms are shown as different sized and different colored spheres.
What can the molecular mass of a molecule or compound be determined by
adding up the atomic mass of its atoms
What is intermolecular forces
the weak electrostatic attractiosn that exist between oppositely charged parts of molecules, or beteen ions and molecules.
What do intermolecular forces result from
the attraction of the positive end of one polar molecule to the negative end of another polar molecule.
When does a hydrogen bond form
if the positively charged hydrogen of one molecule is attracted to the negatively charged oxygen, nitrogen, or flourine of another molecule.
What is an ionic bond
a complete transfer of electrons between two atoms results in seperate positively charged and negative charged ions.
What is polar covalent bond
an unequal sharing of electrons between two atoms results in a slightly positive charge on one side of the molecule and a slightly negative charge.
What is a nonpolar covalent bond
an equal sharing of electrons between two atoms results in an even charge distribution among the atoms of the molecule.
What is a hydrogen bond
the attraction of oppositely charged ends of one polar molecule to another polar molecule hold molecules or parts of molecules together.
What is solubility
the ability of one substance to dissolve in another.
What does dissociate mean
when ionic compounds dissolve in water or seperate from one another because cations are attracted to the negative ends of water and anions attracted to the positive end of water.
What is electrolytes
cations and anions that dissociate in water because they have the capacity to conduct and electric current, which is the flow of charged particles.
What is an electrocardiogram
a recording of electric currents produced by the heart
What is an nonelectrolytes
molecules that do no dissociate form solutions that do not conduct electricity
What is an example of a nonelectrolyte
pure water
maintaining the proper balance of electrolytes is important for?
keeping the body hydrated, controlling blood pH, and ensuring the proper function of muscles and nerves.
When does a chemical reaction occur
when atoms, ions, molecules , or compounds interact either to form or to break chemical bonds.
What are reactants
the substance that enter into a chemical reaction
What is products
substances that result from the chemical reaction.
What are three important points that cna be made about chemical reactions.
less complex reactants are combined to form a larger more complex product.
a reactant can be broken down, or decomposed, into simplier, lexx complex products.
atoms are generally associated with other atoms through chemical bonding or intermolecular forces.
hat is a synthesis reaction
when two or more reactants chemically combine to form a new and larger product.
Whats anabolism
the collective term for synthesis reactions in the body
What is dehydration reaction
synthesis reactions in which water is a product
What is a decomposition reaction
the reverse of a synthesis reaction. a larger reactant is chemically broken down into two or more slammer products.
The anabolic and catabolic reactions int he body are collectively called
metabolism
What is equilibrium
when the rate of a product formation is equal to the rate of the reverse reaction.
What are oxidatio reduction reactions
chemical reactions that result from the exchange of electrons between the reactants
What is oxidation
the loss of an electron by an atom
What is reductionv
the gain of an electron
What is an oxidation reduction reactions
one atom partially or completely loses an electron and another atom gains that electron.
What is energy
the capacity to do work
What is potential energy
stored energy that could do work
What is kinetic energy
is the form of energy that is actually doing work and moving matter.
What is mechanical energy
results from the position or movement of objects.
What is chemical energy
is a form of potential energy within the chemical bonds of a substance.
What are the two types of energy
chemical heat
What is heat energy
is a form of energy that flows from a hotter object to a cooler object.
When does a chemical reaction occur
only when molecules with suficent kinetic energy collide with each other.
What is activation energy
the minimum amount of energy that the reactants must have to start a chemical reaction.
What is a catalyst
substances that increase the rate of chemical reactions without being permeately changed or depleted themselves.
enzymes
increase the rate of a chemical reaction by lowering the activation energy necessary fro the reaction to begin.
What can affect the speed of chemical reactions
temperatures
What is inorganic chemistry
generally deals with substances that do not contain carbon
What is organic chemicstry
is the study of carbon contianing substances
What are some important roles of inorganic molecules
oxygen we breath, carbon dioxide we exhale, water essential for life, calcium phosphate that makes up our bones, metals required for protein functions
What does hydrophobic mean
molecules that lack attraction to water
What are two of the unique properties of water
cohesion and adhesion.
What is cohesion
the attraction of water to another water molecule
What is adhesion
the attraction of water to other molecules.
What are the two ways that water helps stabilize temperature
absorption of heat and evaporation.
What are the two ways that water protects the body
lubricant and cushion.
What is a mixture
a combination of two or more substances physically blended together, but not chemically combines.
What is a solution
any mixture in which the substances are uniformly distributed.
What is a suspension
a mixture containing materials that seperate from each other unless they are continually, physically blended together.
What is an example of a suspension
blood
What is a colloid
a mixture in which a dispersed substance or particle os unevely distributed through the mixture.
What does osmolality reflect
the number, not the type of particles in a solution.
What is another name for a basic solution
alkaline
When does acidosis result
if blood ph drops below 7.35
When does alkalosis result
if blood ph rises above 7.45
What are buffers
chemicals that ressit changes in pH when either acids or bases are added to a solution.
What is a conjugate base
what remains of an acid after the H proton is lost
When is a conjugate acid formed
when a H is transferred to the conjugate base
What is oxygen
an inorganic molecule consisting of two oxygen atoms bound together by a double covalent bond.
What is carbon dioxide
consists of one carbon atom bound to two oxygen atoms.
What are the four major groups of organic molecules essential to living organism
carbohydrates, lipids, proteins, nucleic acids.
What are carbohydrates
are organic molecules composed primarily of carbon, hydrogen, and oxygen atoms and range in size from small to very large.
What are carbohydrates three major roles in the body
they are parts of other organic molecules
they are broken down to provide energy
when undigested they provide bulk in feces.
large carbohydrates are composed of numerous simple building blocks called
monosaccharides.
What are isomers
molecules that have the same number and types of atoms but differ in their three dimensional arrangement
What are disaccharides
composed of two monosacchardies bound together through a dehydration reaction.
What are polysacchardies
long chains of monosaccharides.
What are two important polysaccharides
starch and cellulose
What are lipids
a major group of organic molecules that are defines as being relatively insoluble in water.
What is the important function of lipids in the body
they provide protection and insulation, help regulate many physiological processes, and form plasma membranes.
What are the major classes of lipids
fats, phospholopids, eicosanoids, steroids, fat soluble vitamins
What are the roles of lipids in the body
protection
insulation
regulation
vitamins
structure
energy
What does saturation refer to
the numbe of hydrogen atoms in athe carbon chain
polyunsaturated fats
two or more double covalent bonds between carbon atoms.
Trans fats
unsaturated fats that have been chemically altered by the addition of hydrogen.
What are steroids
lipids that have four ringlike structures
what are some important steroid molecules
cholesterol, bile salts, reproductive hormones estrogen, progesterone, testosterone.
What are proteins important functions in the body
regulate body processes, act as transportation system, provide protection, help muscle contract, provide structure and energy.
What is the role of proteins in the body
regulation, transport, protection, contraction, structure, energy
What are the basic building blocks for proteins.
amino acids.
What are peptide bonds
covalent bonds formed between amino acid molecules during protein synthesis
What is the primary structure of a protein determined by
the sequence of the amino acids bound by peptide bonds.
What is denaturation
is the change in shape caused by the breaking of hydrogen bonds.
What is a domain
a folded sequence of 100-200 amino acids within a protein.
What is a enzyme
a protein catalyst that increases the rate at which a chemical reaction proceeds without the enzyme being permanently changed.
What is the active site
the region of the enzyme that binds reactants and catalyzes their conversion to products.
What is a lipase
enzyme that catalyzes the breakdown of lipids
What is protease
an enzyme that breaks down proteins
What doe enzymes control
the rate at which most chemical reactions proceed in living systems.
What are the two types of nucleic acids
deoxyribonucleic and ribonucleic
What does DNA contain
the information that determines the structure of proteins.
What are the basic building blocks of DNA and RNA
nucleotides
What are complementary base pairs
bases held together by hydrogen bonds.
What does antiparallel mean
that the two strands lie side by side but there sugar phophate extend in opposite directions because of the orientation of the nucleotides.
What is a gene
a sequence of DNA bases that directs the synthesis of proteins or RNA molecules
What do genes determine
the type and sequence of amino acids in protein molecules.
What is ATP
the most important molecule fro storing and providing energy in all living organisms.
What is ATP used for
providing energy for other chemical reactions or toe drive cell processes, such as muscle contraction.
What is ATP often called
the energy currency of cells because it is capable of both storing and proving energy.
Where do all cells originate from
a single fertilized cell
What are important characteristics that are important to each cell type?
cell metabolism and energy use, synthesis of molecules, communication between cells, and inheritence and reproduction.
What is the plasma membrane?
cell membrane that forms the outer boundary of the cell, through which the cell interacts with its external environment.
What does the nucleus do?
directs cell activities
What is the plasma membrane?
lipid bilayer composed of phospholopids and cholesterol.
What is the function of the plasma membrane?
functions are the outer boundary of the cell. control the entry and exit of substances. receptor proteins function in intercellular communication.
What is the nucleus
a double membrane with nuclear pores. contains chromatin which condenses to become visiable mitotic chromosomes during cell division.
What is the function of the nucleus?
it is the control center of the cell. DNA within the nucleus regulates protein synthesis
What is the purpose of rough endoplasmic reticulum
synthesizes proteins, which are usually transported to Gogli apparatus.
What is the purpose of cytoplasmic organelles?
serves as site of protein synthesis.
What are cytoplasmic organelles?
ribosomal RNA and proteins form large and small subunits
What is the role of lipids in the body
protection
insulation
regulation
vitamins
structure
energy
What are the roles of protein in the body
regulation
transport
protection
contraction
structure
energy
What is the rough endoplasmic reticulum
membranous tubules and flattened sacs with attached ribosomes.
What is the smooth endoplasmic reticulum
membranous tubules and flattened sacs with no attached ribosomes.
What is the golgi apparatus
flattened membrane sacs stacked on each other
What is the purpose of golgi apparatus
modifies, packages, and distributes proteins and lipids for secretion or internal use.
What is a lysosome
pinched off golgi apparatus
What is the purpose of lysosomes
contains digestive systems
What is purpose of peroxisome
serves as one site of lipid and amino acid degradation.
What is purpose of proteasomes
break down proteins in cytoplasm
What is proteasomes
tubelike protein complexes in the cytoplasm
What is the purpose of mitochondria
are major sites of ATP synthesis when oxygen is available.
What is the purpose of centrioles
serve as centers for microtubule formation. determine cell polarity during cell division.
What is purpose of cilia
move material over the surface of cells
What is purpose of microvilli
increase surface area of the plasma membrane for absorption and secretion.
How do cells communicate with each other?
chemical and electrical signals
How do muscle cells respond to chemical signals
contracting or relaxing
What are two types of basic microscopes
light and electron
What happens with a transmission electron microscope?
a beam of electrons is passed through an object
What happens with a scanning electron microscope
beams of electrons is reflected off the surface of the object.
What happens with an atomic force miscroscope?
scans the sample using a tiny mechanical probe that can be deflected by small forces between the probe and sample.
What are intracellular substances
those inside the cell.
What are extracellular substances
those outside the cell
what is the membrane potential
an electric charge difference across the plasma membrane
is the outside or the inside of the plasma membrane positively charged
outside.
What does the plasma membrane primarily consist of?
lipids and proteins, and carbohydrates
What are the two types of lipids
phospholipids
cholesterol
lipid bilayer
a double layer of phospholipid molecules
What is lydrophilic
attracted to water
What is hydrophobic
avoid water
What does the fluid mosaic model describe
the plasma membrane as being rigid nor static in structure.
What are several importances in the nature of the lipid bilayer
it provides an important means of distributing molecules within plasma membrane
slight damage to the membrane can be repaired because the phospholipids tend to reassemble around damaged sites
the fluid nature of the lipid bilayer enables membranes to fuse with one another.
What is a major factor in determining the fluid nature of a membrane
the amount of cholesterol in a particular plasma membrane.
What is an important function of the cholesterol
it limits the movement of phospholipids, providing stability to the plasma membrane.
Integral membrane proteins
penetrate deeply into the lipid bilayer, in many cases extending from one surface to the other.
Peripheral membrane proteins
attached to either the inner or the outer surface of the lipid bilayer.
What do integral membrane proteins consist of
regions made up of amino acids with hydrophobic R groups and other regions of amino acids with hydrophilic R groups.
Protein function is determined by what
the proteins chemical characteristics, three dimensional shape of the protein
What can membrane proteins function as
marker molecules, attachment, transport, receptor, enzymes.
What is the function of marker molecules
allow cells to identify other cells or other molecules.
What is function of attachment proteins.
anchor cells to other cells or to extracellular molecules
What is function of transport proteins
form passageways through the plasma membrane allowing specific ions or molecules to enter or exit the cell
What is function of carrier proteins
move ions or molecules across the membrane. binding of specific chemical to carrier proteins causes changes in the shape of the carrier proteins
What is function of ATP powered pumps
move specific ions or molecules across the membrane require ATP molecules to function.
What is function of receptor proteins
function as binding sites for chemical signals in the extracellular fluid.
What is function of enzymes
catalyze chemical reactions either inside or outside cells.
What are glycoproteins
proteins with attached carbohydrates.
What are glycolipids
lipids with attached carbohydrates
What are attachment proteins
integral proteins that allow cells to attach to other cells or to extracellular molecules
What are cadherins
proteins that attach cells to other cells.
What are two examples of attachment proteins
cadherins and integrins
What are integrins
proteins that attach cells to extracellular molecules.
What are transport proteins
integral proteins that allow ions or molecules to move from one side of the plasma membrane to the other.
What are the three characteristics of transport proteins
specificity
competition
saturation
What does specificity mean?
that each transport protein binds to an transports only a certain type of molecule or ion.
What is competition
the result of molecules with similar shape binding to the transport protein
an imaging tech created from sonor technology
ultrasound
microscopic examination of a frozen tissue specimen is an application of ….
histology
what is a cell
the basic structural and functional units of all living orgnisms
the changes an organism undergoes through time
development
What does saturation mean
that the rate of movement of molecules across the membrane is limited by the number of available transport proteins.
What are the three major classes of transport proteins
channel proteins
carrier proteins
Atp powered pumps
What are channel proteins
one or more integral membrane proteins arranged so that they form a tiny channel through the plasma membrane.
What determines which types of ions can pass through the channel
the charges in the hydrophilic part of the channel proteins.
What do channel proteins include
leak ion channels and gated ion channels
What are leak ion channels
nongated ion channels - always open and are responsible for the plasma membranes permeability to ions when the plasma membrane is at rest.
What are gated ion channels
open and close depending on certian conditions of the cell.
What does ligand mean
a generic term for any chemical signal molecule used by cells to communicate with each other
What are ligand gated ion channels
ion channels that respond to ligand signals.
What are voltage gated ion channels
gated ion channels open or close when there is a change in membrane potential.
What is cystic fibrosis
a genetic disorder that affects chloride ion channels.
What are carrier protiens
integral membrane proteins that move ions or molecules from one side of the plasma membrane to the other.
What does the binding of the specific ion or molecule cause
the carrier proteins to change shape and release the bound ion or molecule to the other side of the plasma membrane.
In what three ways can the movement of ions or molecules by carrier proteins be classified
uniport
symport
antiport
What uniport
the movement of one specific ion or molecule across the membrane
What is symport
the movement of two different ions or molecules in the same direction across the plasma membrane
What is antiport
the movement of two differnt ions or molecules in opposite directions across the plasma membrane.
What are ATP powered pumps
transport proteins that require cellular energy to move specific ions or molecules from one side of the plasma membrane to the other.
What are receptor proteins
membrane proteins or glycoprotiens that have an exposed receptor site on the outer cell surface.
What causes a change in the permeability of the plasma membrane to the specific ions passing through the ion channels.
when checmical signals, or ligands, bind to these receptors, the combination alters the three dimensional structure of the protiens of the ion channels, causing the cannels either to open or to close.
The G protein complex consists of what three proteins
alpha, beta, gamma
When does the G protein complex interact with a receptor protein
when a chemical signal is bound to the receptor protein.
an activated subunit can stimulate a cell response in what three ways.
by means of intercellular chemical signals
the opening of ion channels in the plasma membrane
the activation of enzymes associated with the plasma membrane.
The cells survival depends on the maintenence of what differences
intracellular material has a different composition than the extracellular material.
What is a vesicle
a small membrane bound sac.
What is osmosis
water diffuses across a selectively permeable membrane
What is diffusion
random movement of molecules results in net movement from areas of higher to lower concentration.
What is active transport
ATP powered pumps bind to substances and move them across the plasma membrane
What is secondary active transport
Ions are moved across the plasma membrane by active transport, which establishes an ion concetration gradient
What is endocytosis
the plasma membrane forms a vesicle aroudn the substances to be transported and the vesicle is taken into the cell
What happens during passive membrane transport
the cell does not expend metabolic energy
What does passive membrane transport include
diffusion, osmosis, and facilitated diffusion.
What is a solution
consists of one or more substances dissolved in the predominant liquid or gas.
What is diffusion
the movement of solutes from an area of higher solute concentration to an area of lower solute concentration.
When does a concetration difference occur
when the solutes are not evenly distributed in a solvent
What is the concentration gradient
the concetration difference between two points, divided by the distance between the two points.
what causes the concetration gradient to increase
increase the concetration difference between the two points or decreasing the distance between the two points.
What is the rate of diffusion influenced by
the magnitude of the concentration gradient, the temp of the solution, the size of diffusing molecules , the viscocity of solvent.
What happens with the greater concentration gradient
the greater the number of solute particles moving from a higher to a lower solute concentration.
What is viscocity
is a measure of a fluids resitance to flow.
What is osmosis
the diffusion of water across a selectively permeable membrane , such as a plasma membrane.
Why is osmosis important to cells
large volume changes caused by water movement disrupt normal cell function.
What is competition
the result of molecules with similar shape binding to the transport protein
What is osmotic pressure
the force required to prevent water from moving by osmosis across a selectively permeable membrane.
What are three terms to describe the osmotic pressure of solutions
isosmotic, hypersmotic, hyposmotic.
What is hypersmotic
if one solution hasa greater concentration of solute particles, and therefore a greater osmotic pressure than another solution.
What is crenation
the cell shrinks
What does lysis mean
a cell swells
What does osmotic refer to
the concentration of solutions
What does tonic refer to
the tendency of cells t swell or shrink
What is mediated transport
membrane transport process by which membran transport proteins mediate, or assist, the movement of large, water soluble molecules or electrically charged molecules or ions across the plasma membrane.
What is facilitated diffusion
mediated transport process that moves substances into or out of cells from a higher to a lower concentration.
What proteins carry out facilitated diffusion
carrier and channel
What is active transport
a mediated transport process that requires energy provided by ATP
What is secondary active transport
the active transport of an ion, establishing a concentration gradient, with a higher concentration of the ions outside the cell.
What is vesicular transport
the movement of larger volumes of substances across teh plasma membrane through the formation or release of vesicles, membrane bound sacs, in cytoplasm.
What are the two types of vesicular transport
endocytosis and exocytosis
What is endocytosis
occurs when material moves trhough the plasma membrane and into the cytoplasm by the formation of a vesicle.
What are the two types of endocytosis
phagocytosis
pinocytosis
What are phagocytosis importnat for
eliminating harmful substances from the body
pinocytosis
cell drinking
contain molecules dissolved in liquid rather than particles.
What is hypercholesterolemia
a common genetic disorder characterized by the reduction in or absence of low density lipoprotein receptor on cell surfaces, which interferes with the receptor mediated endocytosis of LDL cholesterol.
What are two examples of exocytosis
the secretion of digestive enzymes by the pancreas and secretion of mucus by the salivary glands
What is cytoplasm
the cellular material outside the nucleus but inside the plasma membrane, is about half cytosol and half organelles.
What is the cytosol
the fluid portion of the cytoplasm
What is the cytoskeleton
supports the cell and holds the nucleus and other organelles in place
The cytoskeleton consists of what three groups of proteins
microtubules, actin filaments, intermediate filaments.
What are microtubules
hollow tubes composed primarily of protein units called tubulin.
What are microtubules involved in
cell division and in transport of intracellular materials.
What are actin filaments
are small fibrils, about 8nm in diameter that form bundles, sheets, or networks in cytoplasm.
What are intermediate filaments
protein fibers that provide mechanical strength to cells
What are cytoplasmic inclusions
aggregates of chemicals either produced or taken in by the cell
What are lipochromes?
pigments that increase in amount with age.
What are organelles
structures within cells that are specialized for particular functions.
What is the largest organelle of the cell
nucleus
What are the number of cytoplasmic organelles related to
specific structure and function of cell
What is the nucleus
a large membrane bound structure located near the center of the cell.
What is the nuclear envelope
two membranes separated by a space
What are nuclear pores
pore like openings in the nuclear envelope where the inner and outer membranes fuse. molecules move between the nucleus and the cytoplasm through these openings
What are chromosomes
discrete structures that contain DNA and associated proteins.
What is chromatin
chromospmes dispersed throughout the nucleus as delicate filaments
What does DNA determine
the structural and functional characteristis of the cell by specifying the structure of proteins.
What are the types of RNA molecules
messenger RNA, ribosomal RNA, and transfer RNA>
What is the nucleolus
a dense region within the nucleus
What do free ribosomes do?
synthesize proteins used inside the cell
What does the endoplasmic reticulum consist of
broad, flattened, interconnecting sacs and tubules.
What is the cisternae
the interior spaces of those sacs and tubules and isolated from the rest of the cytoplasm
What is detoxification?
the processes by which enzymes act on chemicals and drugs to change their structure and reduce their toxicity
What is autophagy
lysosomes digest the organelles of the cell that are no longer functional.
What are peroxisomes
membrane bound vesicles that are smaller than lysosomes.
What are proteasomes
large protein complexes containing enzymes that break down and recycle other proteins within the cell.
What is the matrix
the material located inside the inner membrane
What is Tay-Sachs disease?
a rare genetic disorder caused by the inability of lysosomal enzymes to break down gangliosides.
Where is mitochondria more numerous
in areas where ATP is used.
What is the centrosome
a specialized zone of cytoplasm close of the nucleus
What is inside of the centrosome
two centrioles
What is cilia
structures that project from teh surface of cells and are capable of movement.
Where is cilia numerous
on surface cells that line the respitory tract and the female reproductive tract.
What are microvilli
cylindrically shaped extensions of the plasma membrane.
Where is microvilli found
on the cells of intestine, kidney, and other ares where absorption is an important function.
What is heredity
the transmission of genetic traits from parent to offspring
What is each gene
a segment of DNA molecule that specifies the structure of an RNA molecule.
What is gene expression
the production of RNA and or proteins from the infrotmation stored in DNA
What do transfer RNA do
carry the amino acids to the ribosomes.
What is transcription
making a copy of a small part of the stored information in DNA
What is translation
converting that copied information into a protein.
When does transcription occur
when a section of a DNA molecule unwinds and its complementary strands seperate.
What is RNA polymerase
an enzyme that synthesizes the complementary RNA molecule from DNA.
What does a promoter signal
the begining of the gene and site for initial RNA polymerase binding.
What does the attachment of RNA polymerase cause
a portion of the DNA molecule to unwind, exposing the DNA nucleotide sequence fro that region of the template strand.
What is the region between the promoter and termination of transcription called
gene
What are exons
regions of the mRNA that do code for proteins
what is a pre-mRNA
an mRNA that contains introns
What two things are added to the ends of a mRNA
7methyguanosine cap and poly-a tail
What happens in alternative splicing
various combination of exons are incorporated into mRNA. allows for a single gene to produce more than one specific protein.
What is genetic code
the information contained in mRNA and it relates the nucleotide sequence of mRNA to the amino acid sequence of a protein.
What is codon
mRNA organized into three nucleotide sequences.
What is the start codon
AUG
What are end codons
UAA, UGA< UAG
What does translation require
ribosomes and tRNA
What is the function of tRNA
to match a specific amino acid to a specific codon of mRNA
What is an anticodon
three nucleotides that are complementary to a particular codon of mRNA
What is a polyribosome
a cluster of ribosoes attached to the same mRNA
What are the two stages of the cell cycle
interphase and cell division
What stages happen during cell division
mitosis, division of nucleus, cytokinesis, division of cytoplasm
What happens in interphase
the cell prepares to divide
What is DNA replication
the process in which the two strands of a DNA molecule seperate and each serves as the template for making complementary new strands of nucleotides.
What is a diploid number
each cell contains a specific number of chromosomes.
What is a haploid number
half the diploid number
What is mitosis
the division of a cells nucleus into two new nuclei, each containing the same amount and type of DNA as original nucleus.
What is mitotic chromosomes
densely coiled chromatin.
What is a chromatid
a copy of a chromososme
What is kinetochore
a protein structure that binds the centromere and provides a point of attachment for microtubules that will seperate and move the chromatids during mitosis
What happens in prophase
the chromatin condenses to form mitotic chromosomes
What happens in metaphase
the chromosomes align near the center of the cell
What happens in anaphase
the chromatids seperate.
What happens in telophase
nuclear envelopes form around each set of chromosomes to form two seperate nuclei
What is cytokinesis
the division of the cells cytoplasm to produce two new cells.
What is the cleavage furrow
indentation of the plasma membrane that forms midway between the centroiles.
When is cytokinesis complete
when the membranes of the halves seperate at the cleavage furrow to form two seperate cells.
What is Apoptosis
is a normal process by which cell number within various tissues adjust and controled
What is one of the major sources of DNA damage
free radicals- atoms with an unparied electron.