Cholinergic Pharmacology Flashcards
Give examples of reactions to the sympathetic nervous system
Increased heart rate and contractility,
Bronchodilation
Vasoconstriction of skin
Vasodilation of muscle
Dilation of pupils
Reduction in secretion production
Increase in muscle tone
Reduction in pain
Inhibition of digestion, urination
Give examples of reactions to the parasympathetic nervous system
Decreased heart rate,
decrease in respiratory rate
Increased blood supply to the gut
Building energy stores
Constriction of pupils
Increase in secretion production
Increase in GI motility
Defecation, urination, sexual arousal
Sympathetic nervous system receptors
A1 , a2, B1, B2
What are B1 receptors involved in?
Increased heart rate and contractility
What are B2 receptors involved in?
Bronchodilation
Are a1 receptors pre-synaptic or post-synaptic?
Post-synaptic
Are a2 receptors pre-synaptic or post-synaptic?
Pre-synaptic
What are a1 receptors involved in?
vasoconstriction
hat are a2 receptors involved in?
Suppresses release of catecholamines
Alpha blockers block the effect of the ______ nervous system on the blood vessels causing vasodilaiton
sympathetic
Beta-blockers block the effect of the sympathetic nervous system on the heart by decreasing…
rate and contractility, workload of the cardiac muscle, lower heart rate prolongs diastole allowing more time for coronary perfusion, reduced incidence of heart failure
ACE inhibitors cause…
Vasodilation, decreased LV remodelling
For asthma, what class of drugs are used (eg salbutamol)?
Beta 2-agonists (to increase bronchodilation)
Alpha 2 receptor agonists act pre-synaptically to reduce the amount of noradrenaline released, Receptors are found in the brain and ____. For negative feedback loop of sympathetic system
spine
Adrenaline stimulates all the ______ receptors
sympathetic
