Cholinergic Pharmacology

Question 1

Organophosphate poisoning is an example of over activation of the parasympathetic nervous system. Acetycholinersterase is ______

Answer 1

inhibited

Question 2

Atropine competes with _____ at the muscarinic receptors to stop the over activation of the PNS

Answer 2

acetylcholine

Question 3

What are the 2 types of cholinergic receptors?

Answer 3

Nicotinic and muscarinic

Question 4

Nicotinic receptors are p____-______, SNS and PNS

Answer 4

pre-ganglionic

Question 5

Nicotinic receptors are ligand gated ion channels which increase membrane permeability to __ and __

Answer 5

Na+ and K+

Question 6

Muscarinic receptors can be 7 transmembrane helical or _-____ coupled

Answer 6

G-protein

Question 7

Phrase for remembering physiologic manifestations of atropine overdose

Answer 7

“Hot as a hare, blind as a bat, dry as a bone, red as a beet, and mad as a hatter”

Question 8

Buscopan is hyoscine butylbromide, a muscarinic receptor ______

Answer 8

antagonist

Question 9

Buscopan is similar to atropine but doesn’t cross the ___ so causes less sedation or cognitive disturbance

Answer 9

BBB

Question 10

Buscopan used an an antiemetic for abdominal cramps in ___ and to reduce excess respirator secretions in Cerebral palsy or End of life care

Answer 10

IBS

Question 11

Botox acts pre-synaptically, preventing the release of ___ causing flaccid paralysis

Answer 11

ACh

Question 12

Atropine blocks _________ action. It can cross the BBB and can cause confusion, especially in the elderly

Answer 12

parasympathetic

Question 13

Most muscle relaxants used in anaesthesia block the n________ junction by competing with ACh for nicotinic receptors

Answer 13

neuromuscular