Adverse drug interactions

Question 1

Type A (Augmented)

Answer 1

Most common type (80%)
Exaggerated effect of drugs pharmacology at a therapeutic dose
Dose dependent and reversible upon withdrawing the drug

Question 2

Type B (Bizarre)

Answer 2

not related to pharmacology of drug
Not dose relation
Can cause serious illness or mortality
Symptoms do not always resolve upon stopping drug

Question 3

Type C (Chronic/continuing)

Answer 3

ADRs that continue after the drug has been stopped

Question 4

Type D (Delayed)

Answer 4

ADRs that become apparent some time after stopping the drug

Question 5

Type E (End of use/withdrawal)

Answer 5

ADR develops after the drug has been stopped

Question 6

Type F (failure of treatment)

Answer 6

Unexpected treatment failure
Could be due to drug-to-drug interaction or drug-food interaction
Poor compliance with administration instructions

Question 7

Type G (Genetic)

Answer 7

Drug causes irreversible damage to genome

Question 8

What is an alternative way to classify ADRs

Answer 8

DoTS

Question 9

Hypersusceptibility

Answer 9

ADRs at subtherapeutic doses

Question 10

Collateral effects

Answer 10

ADRs at therapeutic doses

Question 11

Toxic effects

Answer 11

ADRs at subpratherapeutic doses

Question 12

What does DoTS stand for?

Answer 12

Dose relatedness,
Timing,
Susceptibility

Question 13

Certain patient groups/ populations may have a specific susceptibility to ADRS from a drug. This can be:

Answer 13

Age
Gender
Disease states
Physiological states