cholinergic drugs

Question 1

Directly acting (Cholinergic agonists)

Answer 1

Pilocarpine, methacholine, bethanechol, carbachol

Question 2

Indirectly acting (Anticholinesterases):
* Reversible

Answer 2

Physostigmine, neostigmine, pyridostigmine,
edrophonium

Question 3

Indirectly acting (Anticholinesterases):
* Irreversible

Answer 3

Organophosphates (parathion, malathion,
ecothiopate),

Nerve gases (Sarin, soman, tabun)

Question 4

pilocarpine uses

Answer 4

• used ft refeaction test to counteract mydriatics
  -irdocyclitis
• open angle glaucoma
  -xerostomia
• sjogren’s syndrome

Question 5

ADR

Answer 5

• CNS stimulation
• miosis and spasm
  -bronchoconstriction
  AV block
  SLUDGE: salivation,lacrimation,urination,diaphoresis,GI upset, emesis